Argon laser and xenon arc coagulation of malignant choroidal melanomata: histological findings in 6 cases.

Abstract

SUMMARYThe histological findings in 6 choroidal melanomata which had been treated by photocoagulation are reported. Bruch's membrane had been ruptured in 5 cases. Vitreous haemorrhage and seeding of tumour cells in the vitreous were observed in 3 cases. Little histological evidence of interference with tumour blood supply was found.

Primary laser photocoagulation of "small" choroidal melanomas

“…One explanation for the present recurrences after apparently successful photocoagulation as evaluated by B-scan ultrasound, fluorescein angiography and ophthalmoscopy, could be the presence of invisible nests of melanoma cells infiltrating the sclera. This scleral invasion was demonstrated histologically in 6 choroidal melanomas enucleated after photocoagulation treatment by Duvall & Lucas (1981). Invasion of melanoma cells in the sclera is frequently seen histopathologically after enucleation (52%, Jensen 1963).…”

Primary laser photocoagulation of "small" choroidal melanomas

“…One explanation for the present recurrences after apparently successful photocoagulation as evaluated by B-scan ultrasound, fluorescein angiography and ophthalmoscopy, could be the presence of invisible nests of melanoma cells infiltrating the sclera. This scleral invasion was demonstrated histologically in 6 choroidal melanomas enucleated after photocoagulation treatment by Duvall & Lucas (1981). Invasion of melanoma cells in the sclera is frequently seen histopathologically after enucleation (52%, Jensen 1963).…”

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

“…), numerous recurrences have been reported [ 83 , 104 ]. Tumor cells may develop resistance and invade the sclera (the outer white layer of the eyeball), promoting recurrence [ 105 , 106 ]. Furthermore, photocoagulation is technically limited to small tumors [ 15 ].…”

Primary laser photocoagulation of "small" choroidal melanomas

“…One explanation for the present recurrences after apparently successful photocoagulation as evaluated by B-scan ultrasound, fluorescein angiography and ophthalmoscopy, could be the presence of invisible nests of melanoma cells infiltrating the sclera. This scleral invasion was demonstrated histologically in 6 choroidal melanomas enucleated after photocoagulation treatment by Duvall & Lucas (1981). Invasion of melanoma cells in the sclera is frequently seen histopathologically after enucleation (52%, Jensen 1963).…”

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

“…), numerous recurrences have been reported [ 83 , 104 ]. Tumor cells may develop resistance and invade the sclera (the outer white layer of the eyeball), promoting recurrence [ 105 , 106 ]. Furthermore, photocoagulation is technically limited to small tumors [ 15 ].…”

Primary laser photocoagulation of "small" choroidal melanomas

“…One explanation for the present recurrences after apparently successful photocoagulation as evaluated by B-scan ultrasound, fluorescein angiography and ophthalmoscopy, could be the presence of invisible nests of melanoma cells infiltrating the sclera. This scleral invasion was demonstrated histologically in 6 choroidal melanomas enucleated after photocoagulation treatment by Duvall & Lucas (1981). Invasion of melanoma cells in the sclera is frequently seen histopathologically after enucleation (52%, Jensen 1963).…”

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

“…), numerous recurrences have been reported [ 83 , 104 ]. Tumor cells may develop resistance and invade the sclera (the outer white layer of the eyeball), promoting recurrence [ 105 , 106 ]. Furthermore, photocoagulation is technically limited to small tumors [ 15 ].…”