Arginine supplementation for prevention of necrotising enterocolitis in preterm infants

Abstract

The data are insufficient at present to support a practice recommendation. A multicentre randomized controlled study of arginine supplementation in preterm neonates is needed, focusing on the incidence of NEC, particularly stage 2 or 3.

Infant ENOS haplotypes and maternal PIH

“…Several investigators have reported the utility of L-Arginine supplementation in treating infants with necrotizing enterocolitis [27][28][29][30]. Our data suggests that the fetal genotypes may influence feto-maternal circulation contributing to PIH.…”

Infant ENOS haplotypes and maternal PIH

“…Several investigators have reported the utility of L-Arginine supplementation in treating infants with necrotizing enterocolitis [27][28][29][30]. Our data suggests that the fetal genotypes may influence feto-maternal circulation contributing to PIH.…”

Gut Microbial Gene Expression in Mother-Fed and Formula-Fed Piglets

“…Interestingly, we observed a clear abundance of enzymes linked to arginine metabolism in the MF group of animals. This finding may have clinical relevance because several reports have indicated that an abnormally low serum concentration of arginine, a precursor for nitric oxide production, confers an increased risk for NEC [69] , [70] , and it is widely accepted that the incidence of NEC is lower in low birthweight infants receiving breast milk [7] , [8] . Additionally, the MF data sets were significantly enriched in oxidative stress response genes, which is interesting in light of the oft-stated belief that breast milk provides antioxidant protection for newborns.…”

Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets

“…Arginine is a versatile amino acid that has a key role in immunity and barrier function, and its degradation depends on the enzyme ARG2 in enterocytes. Arginine supplementation has previously been shown to reduce NEC (2,48), and in fact arginine supplementation has been considered as a prophylactic treatment for NEC (57). The reduced level of ARG2 in ANTI pigs would suggest higher levels of tissue and plasma arginine and may also have contributed to the reduction in incidence and severity of NEC in the ANTI preterm pigs.…”

Infant ENOS haplotypes and maternal PIH

“…Several investigators have reported the utility of L-Arginine supplementation in treating infants with necrotizing enterocolitis [27][28][29][30]. Our data suggests that the fetal genotypes may influence feto-maternal circulation contributing to PIH.…”

Gut Microbial Gene Expression in Mother-Fed and Formula-Fed Piglets

“…Interestingly, we observed a clear abundance of enzymes linked to arginine metabolism in the MF group of animals. This finding may have clinical relevance because several reports have indicated that an abnormally low serum concentration of arginine, a precursor for nitric oxide production, confers an increased risk for NEC [69] , [70] , and it is widely accepted that the incidence of NEC is lower in low birthweight infants receiving breast milk [7] , [8] . Additionally, the MF data sets were significantly enriched in oxidative stress response genes, which is interesting in light of the oft-stated belief that breast milk provides antioxidant protection for newborns.…”

Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets

“…Arginine is a versatile amino acid that has a key role in immunity and barrier function, and its degradation depends on the enzyme ARG2 in enterocytes. Arginine supplementation has previously been shown to reduce NEC (2,48), and in fact arginine supplementation has been considered as a prophylactic treatment for NEC (57). The reduced level of ARG2 in ANTI pigs would suggest higher levels of tissue and plasma arginine and may also have contributed to the reduction in incidence and severity of NEC in the ANTI preterm pigs.…”

Infant ENOS haplotypes and maternal PIH

“…Several investigators have reported the utility of L-Arginine supplementation in treating infants with necrotizing enterocolitis [27][28][29][30]. Our data suggests that the fetal genotypes may influence feto-maternal circulation contributing to PIH.…”

Gut Microbial Gene Expression in Mother-Fed and Formula-Fed Piglets

“…Interestingly, we observed a clear abundance of enzymes linked to arginine metabolism in the MF group of animals. This finding may have clinical relevance because several reports have indicated that an abnormally low serum concentration of arginine, a precursor for nitric oxide production, confers an increased risk for NEC [69] , [70] , and it is widely accepted that the incidence of NEC is lower in low birthweight infants receiving breast milk [7] , [8] . Additionally, the MF data sets were significantly enriched in oxidative stress response genes, which is interesting in light of the oft-stated belief that breast milk provides antioxidant protection for newborns.…”

Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets

“…Arginine is a versatile amino acid that has a key role in immunity and barrier function, and its degradation depends on the enzyme ARG2 in enterocytes. Arginine supplementation has previously been shown to reduce NEC (2,48), and in fact arginine supplementation has been considered as a prophylactic treatment for NEC (57). The reduced level of ARG2 in ANTI pigs would suggest higher levels of tissue and plasma arginine and may also have contributed to the reduction in incidence and severity of NEC in the ANTI preterm pigs.…”