2011
DOI: 10.1074/jbc.m111.273912
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Abstract: Background: Arginine dimethylation in proteins has been reported to affect nuclear import. Results: Arginine methylation of the nuclear poly(A) binding protein in the binding site for its import receptor, transportin, weakens the interaction about 10-fold. Conclusion: We hypothesize that a delay of methylation until after import may contribute to the directionality of import. Significance: This may be a general mechanism of regulating nuclear import.

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Cited by 30 publications
(50 citation statements)
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“…The 61-amino-acid-long C-terminal domain of nucleolin, a prototype RGG domain, lacks stable secondary or tertiary structure, at least in isolation (Zahariev et al , 2005 ). The C-terminal domain of PABPN1 can safely be assumed to lack stable structure, as it is a binding site for transportin (Calado et al , 2000a ;Fronz et al , 2011 ), which is known to bind its cargo in an unfolded or mostly unfolded conformation (Lee et al , 2006 ;Cansizoglu et al , 2007 ;Imasaki et al , 2007 ;Zhang and Chook , 2012 ).…”
Section: The Problem Of Prmt Substrate Specificitymentioning
confidence: 99%
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“…The 61-amino-acid-long C-terminal domain of nucleolin, a prototype RGG domain, lacks stable secondary or tertiary structure, at least in isolation (Zahariev et al , 2005 ). The C-terminal domain of PABPN1 can safely be assumed to lack stable structure, as it is a binding site for transportin (Calado et al , 2000a ;Fronz et al , 2011 ), which is known to bind its cargo in an unfolded or mostly unfolded conformation (Lee et al , 2006 ;Cansizoglu et al , 2007 ;Imasaki et al , 2007 ;Zhang and Chook , 2012 ).…”
Section: The Problem Of Prmt Substrate Specificitymentioning
confidence: 99%
“…Although the RRM of PABPN1 can dimerize (see above), the C-terminal domain also contributes to homotypic interactions and is responsible for the cooperativity of RNA binding (Fan et al , 2001 ;. Although arginine methylation occurs in a domain contributing to both RNA binding and cooperativity, the modification has a marginal effect at best, maybe a 2-fold increase in affinity and no detectable change in specificity or cooperativity Fronz et al , 2011 ). Likewise, although the related RGG domain of other RNA-binding proteins contributes to RNA binding, its methylation generally does not appear to affect this activity (Valentini et al , 1999 ;Raman et al , 2001 ).…”
Section: Functional Consequences Of Pabpn1 Methylationmentioning
confidence: 99%
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