2005
DOI: 10.1097/01.hjh.0000166837.78559.93
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Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats

Abstract: Our results showed that arginase inhibition reduced endothelial dysfunction and blood pressure rising in SHR.

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Cited by 141 publications
(146 citation statements)
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“…In contrast, nor-NOHA had no effect on ACh-induced relaxation in control rats. These findings indicate that increased arginase contributes to endothelial dysfunction, probably by limiting the L-arginine availability for NOS, as previously observed in animal models of cardiovascular diseases (19)(20)(21)(22)24). It is noteworthy that beyond its effect on vascular NO production, decreased L-arginine availability secondary to arginase up-regulation might theoretically contribute to the eNOS uncoupling recently identified in vessels of AIA rats (12).…”
Section: Discussionsupporting
confidence: 81%
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“…In contrast, nor-NOHA had no effect on ACh-induced relaxation in control rats. These findings indicate that increased arginase contributes to endothelial dysfunction, probably by limiting the L-arginine availability for NOS, as previously observed in animal models of cardiovascular diseases (19)(20)(21)(22)24). It is noteworthy that beyond its effect on vascular NO production, decreased L-arginine availability secondary to arginase up-regulation might theoretically contribute to the eNOS uncoupling recently identified in vessels of AIA rats (12).…”
Section: Discussionsupporting
confidence: 81%
“…Arginase uses L-arginine (the substrate of NOS) as substrate and can thereby limit the availability of L-arginine for NO synthesis. Consistent with this theory are the studies demonstrating that arginase inhibition enhanced NOmediated vasodilatory function under pathologic conditions such as aging, hypertension, diabetes, and atherosclerosis (19)(20)(21)(22)(23)(24). Therefore, inhibition of vascular arginase activity might represent a new pharmacologic strategy for increasing availability of arginine for NO synthesis in conditions associated with endothelial dysfunction.…”
Section: Discussionmentioning
confidence: 78%
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