Arginase-1 Variants and the Risk of Familial Coronary Artery Disease in Subjects Originating from Pakistan

Shah, Syed Fawad Ali; Khan, Muhammad Jadoon; Iqbal, Tahir; Akram, Sumaira; Waheed, Farah; Satti, Humayoon Shafique; Rafiq, Muhmmad Arshad; Hussain, Shahzad

doi:10.1089/gtmb.2018.0227

Cited by 6 publications

(6 citation statements)

References 24 publications

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“… 35 Shah et al 2019 reported a 2.7–4.7 U/L increase in Arginase-1 activity in CHD patients, compared to healthy controls with 1.12–1.4 U/L. 36 NO level seems to be significantly lower in coronary heart patients than in healthy people. NO production would decrease when an increase in ARG-1 levels occurred.…”

Section: Discussionmentioning

confidence: 98%

The Potential of Single Nucleotide Polymorphisms (SNPs) as Biomarkers and Their Association with the Increased Risk of Coronary Heart Disease: A Systematic Review

Sitinjak,

Murdaya,

Rachman

et al. 2023

VHRM

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Human genetic analyses and epidemiological studies showed a potential association between several types of gene polymorphism and the development of coronary heart disease (CHD). Many studies on this pertinent topic need to be investigated further to reach an evidence-based conclusion. Therefore, in this current review, we describe several types of gene polymorphisms that are potentially linked to CHD. A systematic review using the databases EBSCO, PubMed, and ScienceDirect databases was searched until October of 2022 to find relevant studies on the topic of gene polymorphisms on risk factors for CHD, especially for the factors associated with single nucleotide polymorphisms (SNPs). The risk of bias and quality assessment was evaluated by Joanna Briggs Institute (JBI) guidelines. From keyword search results, a total of 6243 articles were identified, which were subsequently narrowed to 14 articles using prespecified inclusion criteria. The results suggested that there were 33 single nucleotide polymorphisms (SNPs) that can potentially increase the risk factors and clinical symptoms of CHD. This study also indicated that gene polymorphisms had a potential role in increasing CHD risk factors that were causally associated with atherosclerosis, increased homocysteine, immune/inflammatory response, Low-Density Lipoprotein (LDL), arterial lesions, and reduction of therapeutic effectiveness. In conclusion, the findings of this study indicate that SNPs may increase risk factors for CHD and SNPs show different effects between individuals. This demonstrates that knowledge of SNPs on CHD risk factors can be used to develop biomarkers for diagnostics and therapeutic response prediction to decide successful therapy and become the basis for defining personalized medicine in future.

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Section: Discussionmentioning

confidence: 98%

The Potential of Single Nucleotide Polymorphisms (SNPs) as Biomarkers and Their Association with the Increased Risk of Coronary Heart Disease: A Systematic Review

Sitinjak,

Murdaya,

Rachman

et al. 2023

VHRM

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“…Standard techniques were adopted for the collection of venous blood samples/serum from the participants. [ 10 ] Serum was stored at −80°C for the analysis of biochemical and clinical markers. The nonenzymatic salting out approach was used to extract deoxyribonucleic acid (DNA) from whole blood for single-nucleotide polymorphism (SNP) analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Serum levels of nitrite, nitrate, and ARG1 were determined by enzyme-linked immunosorbent assay technique as described earlier. [ 10 ]…”

Section: Methodsmentioning

confidence: 99%

Association analysis of single nucleotide polymorphisms in autophagy related 7 (ATG7) gene in patients with coronary artery disease

et al. 2022

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Recent experimental studies sparked the involvement of autophagy-related 7 (ATG7) in the development of atherosclerosis. However, the genetic variants and their association with coronary artery disease (CAD) are still to be unveiled. Therefore, we aimed to design a retrospective case-control study for the analysis of ATG7 gene polymorphisms and their association with CAD among the subjects originating from Pakistan. The ATG7 noncoding polymorphisms (rs1375206; Chr3:11297643 C/G and rs550744886; Chr3:11272004 C/G) were examined in 600 subjects, including 300 individuals diagnosed with CAD. Arginase-1 (ARG1) and nitric oxide metabolites were measured by the colorimetric enzymatic assay. Genotyping of noncoding ATG7 polymorphisms was accomplished by the polymerase chain reaction–restriction fragment length polymorphism method. A significant association of ATG7 (rs1375206 and rs550744886) was observed in individuals exhibiting CAD ( P < .0001, for each single-nucleotide polymorphism). Moreover, variant allele G at both loci showed high occurrence and significant association with the disease phenotype as compared to the wild-type allele (odds ratio [OR] = 2.03, P < .0001 and OR = 2.08, P < .001, respectively). Variant genotypes at ATG7 rs1375206 and rs550744886 showed significant association with high concentrations of ARG1 and low nitric oxide metabolites among the patients ( P < .0001 for each). A significant difference was noted in the distribution of the haplotype G-G, mapped at Chr3:11297643-11272004 between cases and controls ( P < .0001). The study concludes that ATG7 polymorphisms are among the risk factors for CAD in the subjects from Pakistan. The study thus highlights the novel risk factors for high incidents of the disease and reported for the first time to the best of our knowledge.

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“…Arginase I is present in the cytoplasm of the liver cells and has a major role in the urea cycle, while Arginase II is founded in almost all tissues, it is more prevalent in the kidney, prostate, digestive and gastrointestinal system, muscle, and endocrine tissues [8,9]. Arginase's role in vascular dysfunction linked to CVD was primarily researched since studies found that it was expressed in both endothelium and smooth muscle vascular cells [10]. Endothelial dysfunction is associated with decreased NO bioavailability in disease conditions such as acute myocardial infarction (MI).…”

Section: Introductionmentioning

confidence: 99%

Study of the Arginase Activity and Other Biochemical Parameters in Patients with Coronary Artery Disease in Baghdad Governorate-Iraq

Hussain

Muftin

Al-jibouri

et al. 2023

Al-Mustansiriyah Journal of Science

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The most prevalent form of heart disease and the main cause of death in both developed and developing nations is CAD. It happens when "plaque," or cholesterol or other fatty deposits that accumulate on the inner wall of the artery, narrows or blocks the arteries that deliver blood to the heart. Over time, chest pain might develop as a result of the reduction in blood flow to the heart caused by this plaque accumulation. The study was designed to find if Arginase acts as a biomarker for diagnosing Coronary Artery Disease (CAD). A total of 90 individual samples were included in the present study, the control group consist of 40 healthy individual samples, while the CAD patients were 50 individual samples. Some biochemical parameters such as fasting blood glucose (FBG), troponin I(TnI), high sensitivity C-reactive protein (hs-CRP), lipid profile, lactate dehydrogenase (LDH), and Arginase activity were analyzed. The results of the current study showed no significant differences in the average age of patients (67.00±6.78) when compared with the control group (61.10±6.46), P>0.05. A significant increase Was found in the FBI level, cholesterol, triglycerides, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), TnI, hs-CRP, LDH, and Arginase activity in the patient's group when compared with the control group. While significant decrease (P<0.05) was revealed in the high-density lipoprotein (HDL) level in CAD patients in comparison to the control group. Also, there was a positive significant correlation between Arginase activity with each age and FBG. As for the ROC operator curve for Arginase, it was found that the area under the curve (AUC) was 0.953 with a sensitivity of 90%, and specificity of 95%. The results in the present study indicate a possible use of Arginase as a diagnostic marker for CAD.

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Arginase-1 Variants and the Risk of Familial Coronary Artery Disease in Subjects Originating from Pakistan

Cited by 6 publications

References 24 publications

The Potential of Single Nucleotide Polymorphisms (SNPs) as Biomarkers and Their Association with the Increased Risk of Coronary Heart Disease: A Systematic Review

The Potential of Single Nucleotide Polymorphisms (SNPs) as Biomarkers and Their Association with the Increased Risk of Coronary Heart Disease: A Systematic Review

Association analysis of single nucleotide polymorphisms in autophagy related 7 (ATG7) gene in patients with coronary artery disease

Study of the Arginase Activity and Other Biochemical Parameters in Patients with Coronary Artery Disease in Baghdad Governorate-Iraq

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