Argentinian collaborative study on prevalence of erythromycin and penicillin susceptibility in Streptococcus pyogenes

Lopardo, Horacio; Venuta, María Elena; Vidal, Patricia; Rosaenz, Liliana; Corthey, Carlos; Farinati, Alicia; Couto, Elsa; Sarachian, Beatriz; Sparo, Mónica; Kaufman, Sara; Mier, Carmen A De; Gubbay, Laura; Scilingo, Viviana M.; Villaverde, Patricia

doi:10.1016/s0732-8893(97)00070-9

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…At that time, resistant strains were only sporadically observed (1.5%). In 1997, a multicentre study involving centres all over the country was published, confirming previously reported low prevalence (1.5%) of erythromycin resistant GAS but indicating a different regional distribution of resistant strains [25]. In 2000, a regional study showed 11% resistance, a higher value than previous reports but similar to that of the former report from the same region [26].…”

Section: Introductionsupporting

confidence: 79%

Genetic and phenotypic characterization of resistance to macrolides in Streptococcus pyogenes from Argentina

Martínez

2004

International Journal of Antimicrobial Agents

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Five hundred and seventy-eight strains of group A streptococci (GAS) isolated mostly from paediatric pharyngeal swabs were tested to evaluate their susceptibility to erythromycin. Resistant strains were then tested for their MICs to erythromycin and clindamycin, their phenotype of resistance to macrolides-lincosamides-streptogramin (MLS B ) and for the presence of macrolide resistance genes. The rate of resistance to erythromycin was 8.2%. Constitutive, inducible and M phenotypes of resistance were detected in 2.1, 2.1 and 95.8% of resistant strains, respectively. All M phenotypes harboured the mefA gene, whereas constitutive and inducible phenotypes had ermB and ermTR genes, respectively.

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Section: Introductionsupporting

confidence: 79%

Genetic and phenotypic characterization of resistance to macrolides in Streptococcus pyogenes from Argentina

Martínez

2004

International Journal of Antimicrobial Agents

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“…equisimilis isolates were Tet r as previously described (20). Tet r isolates were found within types stG10 (n ϭ 3), stG480 (n ϭ 2), stC36 (n ϭ 1), stG6 (n ϭ 4), and stC6979 (n ϭ 1).…”

Section: Resultsmentioning

confidence: 99%

“…Serotyping and antimicrobial testing of streptococci recovered in Argentina have previously focused on pharyngeal isolates (16,20,30), but information concerning recently recovered invasive streptococcal isolates is lacking. In gram-positive organisms, erythromycin (ERY) resistance is mediated by either target modification or active efflux (17,29).…”

mentioning

confidence: 99%

Six-Month Multicenter Study on Invasive Infections Due to Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis in Argentina

Lopardo¹,

Vidal²,

Sparo

et al. 2005

J Clin Microbiol

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During a 6-month period, 95 invasive infections due to Streptococcus pyogenes and group C or group G Streptococcus dysgalactiae subsp. equisimilis were recorded from 40 centers of 16 cities in Argentina. We describe here epidemiologic data available for 55 and 19 patients, respectively, associated with invasive infections due to S. pyogenes and S. dysgalactiae subsp. equisimilis. The associated isolates and 58 additional pharyngeal isolates were genotyped and subjected to serologic and/or antibiotic susceptibility testing. Group A streptococcal emm type distribution and strain association with toxic shock appeared to differ somewhat from results found within the United States; however, serologic characterization and sof sequence typing suggested that emm types found in both countries are reflective of shared clonal types.

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“…The rate of macrolide resistance varies between different countries. It remains low (5%) in the Tunis area, and even lower in Argentina <1% [22]. In Europe, the rates of resistance over the last decade have ranged from 2% in the UK, to 10% in Sweden, to 17% in Finland, and up to 47% in Italy [23].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological markers of Streptococcus pyogenes strains in Tunisia

Hraoui

Boubaker

Doloy

et al. 2011

Clinical Microbiology and Infection

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To further understand the epidemiology of Streptococcus pyogenes or group A streptococcus (GAS) infections in Tunisia, phenotypic and genomic markers of GAS isolates, including antibiotic susceptibility, biotypes, T and emm types and toxin gene profiles, have been characterized. A total of 103 isolates, collected between 2000 and 2006, were investigated; 47 were recovered from invasive infections, and 56 from non-invasive infections. Rates of resistance to tetracycline, erythromycin, clindamycin and rifampin were 70.8%, 4.8%, 4.8% and 0.9%, respectively. High levels of resistance to streptomycin and kanamycin were observed in 1.9% and 4.8% of isolates, respectively. Biotype 3 was most common. Twenty different T patterns were observed, with a predominance of T3/13/B3264, and 38 different emm types. In both invasive and non-invasive isolates, emm118 (9.7%), emm42 (8.7%), emm1 (7.8%), st432 (6.8%), emm28 (5.8%) and emm76 (5.8%) were the most prevalent types; emm1, emm76 and emm18 were mainly observed among invasive infections, whereas emm118 (12.5%), emm42 (10.7%) and emm28 (8.9%) were predominant among non-invasive infections. The speB gene was detected in all isolates, but there were variable frequencies of speA, speC and ssa (20.3%, 32% and 25.2% respectively). Significant associations of emm1, emm18 and emm3 with speA and of emm4 and st432 with ssa were found. This first report from Tunisia revealed a unique emm distribution of GAS that differs from those of other regions. This information on the distribution of such emm types will be useful for the development of an appropriate vaccine in a country where the incidence of rheumatic fever remains high.

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Argentinian collaborative study on prevalence of erythromycin and penicillin susceptibility in Streptococcus pyogenes

Cited by 12 publications

References 13 publications

Genetic and phenotypic characterization of resistance to macrolides in Streptococcus pyogenes from Argentina

Genetic and phenotypic characterization of resistance to macrolides in Streptococcus pyogenes from Argentina

Six-Month Multicenter Study on Invasive Infections Due to Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis in Argentina

Epidemiological markers of Streptococcus pyogenes strains in Tunisia

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