2018
DOI: 10.1128/aac.00737-18
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Abstract: Paracoccidioidomycosis (PCM) is the cause of many deaths from systemic mycoses. The etiological agents of PCM belong to the genus, which is restricted to Latin America. The infection is acquired through the inhalation of conidia that primarily lodge in the lungs and may disseminate to other organs and tissues. The treatment for PCM is commonly performed via the administration of antifungals such as amphotericin B, co-trimoxazole, and itraconazole. The antifungal toxicity and side effects, in addition to their … Show more

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Cited by 10 publications
(9 citation statements)
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References 59 publications
(80 reference statements)
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“…The 16 specific immunogenic proteins of P. lutzii can be divided into three main groups. Group 1 comprises seven proteins that have been widely reported in Paracoccidioides under experimental physiological conditions according to STRING analysis, namely, triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase, citrate synthase, isocitrate lyase, enolase, HSP60-like protein, and an uncharacterized protein (thioredoxin-like superfamily) [ 54 , 70 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ]. Proteins included in group 2 are antigens that already have been described in human PCM, such as triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase, fructose-bisphosphate aldolase [ 70 ], or Paracoccidioides antigens that already have been related to eliciting a humoral immune response in BALB/c mice, such as transketolase, HSP60-like protein, and isocitrate lyase (all shared with PS3) [ 71 ].…”
Section: Discussionmentioning
confidence: 99%
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“…The 16 specific immunogenic proteins of P. lutzii can be divided into three main groups. Group 1 comprises seven proteins that have been widely reported in Paracoccidioides under experimental physiological conditions according to STRING analysis, namely, triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase, citrate synthase, isocitrate lyase, enolase, HSP60-like protein, and an uncharacterized protein (thioredoxin-like superfamily) [ 54 , 70 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ]. Proteins included in group 2 are antigens that already have been described in human PCM, such as triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase, fructose-bisphosphate aldolase [ 70 ], or Paracoccidioides antigens that already have been related to eliciting a humoral immune response in BALB/c mice, such as transketolase, HSP60-like protein, and isocitrate lyase (all shared with PS3) [ 71 ].…”
Section: Discussionmentioning
confidence: 99%
“…The 25 specific immunogenic proteins of P. brasiliensis can be divided into three main groups. Group 1 comprises 13 proteins that have already been described in Paracoccidioides under experimental physiological condition, namely, triosephosphate isomerase, spermidine synthase, glyceraldehyde-3-phosphate dehydrogenase, 4-hydroxyphenylpyruvate dioxygenase, thioredoxin reductase, ATP synthase subunit beta, hexokinase, HSP75-like protein, HSP60-like protein, HSP7-like protein, aconitate hydratase, mitochondrial, 1-Cys peroxiredoxin, and an uncharacterized protein (XP_010758132) [ 54 , 70 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 ], all of them enriched in our STRING network. Proteins in group 2 correspond to antigens that have already been described in human PCM [ 70 ] or immunogens that have already been described to elicit a humoral immune response in BALB/c mice, such as HSP7-like protein and HSP 60-like protein [ 71 ].…”
Section: Discussionmentioning
confidence: 99%
“…The medicinal potential of plants as antifungals comes from their extracts, essential oils, and chemical constituents [ 46 ]. Several studies have reported compounds with antifungal properties against PCM, such as argentilactone derived from Hyptis ovalifolia [ 47 ], oenothein B derived from Eugenia uniflora [ 48 , 49 ], fatty acid methyl esters and compounds derived from Annona cornifolia essential oils [ 50 ], hydroalcoholic extracts from the species Piper regnellii and Baccharis dracunculifolia [ 51 , 52 ], and curcumin from Curcuma longa [ 53 ]. Another natural compound is ajoene, derived from Allium sativum , which exerts inhibitory effects against morphological transition and in yeast cells, with possible involvement in the sulfhydryl metabolism of P. brasiliensis [ 54 ].…”
Section: New Anti- Paracoccidioides Compounds: mentioning
confidence: 99%
“…The mode of action of argentilactone against that pathogen was investigated in 2015, 2016, and 2018 by proteomics [ 120 ], transcriptomics [ 115 ], and chemoproteomics [ 47 ], respectively. Some common results of those three techniques can be evidenced.…”
Section: The Identification Of the Mode Of Action Of Compounds Basmentioning
confidence: 99%
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