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Cited by 73 publications
(44 citation statements)
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“…These compounds make use of the commercially available and inexpensive tris(dimethylamino)phosphine ligand, making them much more attractive for practical applications than the examples discussed above containing rather elaborated water-soluble phosphines. In particular, the hexamethylbenzene derivative [RuCl 2 ( 6 -C 6 Me 6 ){P(NMe 2 ) 3 }] (10) proved to be highly efficient, providing the desired amides from a wide range of organonitriles in excellent yields and short times [46,47]. TOF values up to 11400 h -1 , the highest reported to date for this catalytic transformation in pure water, were reached with complex 10 by performing the catalytic reactions at 150 ºC under MW irradiation.…”
Section: Scheme 5 Catalytic Hydration Of Nitriles Using Cis-[ru(acacmentioning
confidence: 99%
See 1 more Smart Citation
“…These compounds make use of the commercially available and inexpensive tris(dimethylamino)phosphine ligand, making them much more attractive for practical applications than the examples discussed above containing rather elaborated water-soluble phosphines. In particular, the hexamethylbenzene derivative [RuCl 2 ( 6 -C 6 Me 6 ){P(NMe 2 ) 3 }] (10) proved to be highly efficient, providing the desired amides from a wide range of organonitriles in excellent yields and short times [46,47]. TOF values up to 11400 h -1 , the highest reported to date for this catalytic transformation in pure water, were reached with complex 10 by performing the catalytic reactions at 150 ºC under MW irradiation.…”
Section: Scheme 5 Catalytic Hydration Of Nitriles Using Cis-[ru(acacmentioning
confidence: 99%
“…TOF values up to 11400 h -1 , the highest reported to date for this catalytic transformation in pure water, were reached with complex 10 by performing the catalytic reactions at 150 ºC under MW irradiation. Remarkably, taking advantage of the outstanding performance of [RuCl 2 ( 6 -C 6 Me 6 ){P(NMe 2 ) 3 }] (10), unprecedented synthetic routes for the preparation of the non-steroidal anti-inflammatory drugs ibuprofenamide and ketoprofenamide, by catalytic hydration of 2-(4-isobutylphenyl)propionitrile and 2-(3-benzoylphenyl)propionitrile, respectively, were developed (Scheme 6) [46,47]. The synthetic utility of complexes [RuCl 2 ( 6 -arene){P(NMe 2 ) 3 }] was further demonstrated in the challenging hydration of cyanohydrins (-hydroxynitriles), substrates usually difficult to hydrate because they degrade to produce cyanide which poisons the catalysts.…”
Section: Scheme 5 Catalytic Hydration Of Nitriles Using Cis-[ru(acacmentioning
confidence: 99%
“…[1,3,4] An attractive alternative methodi st he homogenous [1][2][3][4]6] or heterogeneous [7][8][9][10][11] metal-catalyzed nitrile hydration. [1,[12][13][14][15][16][17] Ru II and Ru IV complexes with nitrogen-containing phosphine ligands (for example, [RuCl 2 (h 6 -arene)(P(NMe 2 ) 3 )]) have shown significant activity for nitrile hydration. [2] Ruthenium complexesh ave been utilized as efficient and versatile catalysts for nitrile hydration to amides.…”
Section: Introductionmentioning
confidence: 99%
“…Co, Ni, and Ru tend to be selective for primary amines, 15,16,18,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] whereas Cu and Rh are selective for secondary amines, 15,22 and Pd and Pt are selective for tertiary amines. 11 These catalysts have also been used for the secondary and tertiary amine synthesis by the N-alkylation of ammonia and related compounds with alcohol on a [Ru(pcymene)Cl 2 ] 2 and dppf (=1,1 0 -bis(diphenylphosphino)ferrocene) ligand system, 41 and Ru(OH) x supported oxide catalysts; [42][43][44] the synthesis of amides on RuCl 2 (Z 6 -C 6 Me 6 ){P(NMe 2 ) 3 }, 45 cis-Ru(acac) 2 (PPh 2 py) 2 , (acac = acetylacetonato, PPh 2 py = diphenyl-2-pyridylphosphine), 46 and Ru(OH) x /Al 2 O 3 ; 47 the synthesis of nitriles on RuH 2 (PPh 3 ) 4 , 48 RuH(bmpi)(PPh 3 ) 2 (bmpi = 1,3-bis(6 0methyl-2 0 -pyridylimino)isoindoline), 49 Ru/Al 2 O 3 , 50 and Ru(OH) x supported oxide catalysts; 51-55 the synthesis of aldimines 56 and the aerobic oxidation of alcohol on Ru(OH) x supported oxide catalysts; 54,55,57,58 and the synthesis of alcohol on Ru(OH) x supported oxide catalysts. 33 Segobia et al reported that transition metals (Ni, Co, Ru, Cu, Pd, and Pt) supported on silica ...…”
Section: Introductionmentioning
confidence: 99%