Are there HLA combinations typical supporting for or making resistant against aggressive and/or chronic periodontitis?

Stein, J.; Reichert, Stefan; Gautsch, A.; Machulla, Helmut K.G.

doi:10.1034/j.1600-0765.2003.00683.x

Cited by 45 publications

(52 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A possibility that CD14-TT was primarily associated with periodontitis and secondarily with BD could not be neglected, because it was recently reported that CD14-TT genotype was associated with periodontitis (Laine et al 2005), although other reports showed no association with the CD14 polymorphism (James et al 2007) or signiWcantly higher frequency of CD14-C allele in female patients with periodontitis (Folwaczny et al 2004). Similar situation could be considered for the association with DRB1*1501, because several reports suggested the association of periodontitis with speciWc HLA alelels including DRB1*1501 (Ohyama et al 1996;Stein et al 2003) and DQB1*0602 (Ohyama et al 1996). It is quite interesting to note here that DRB1*1501-DQB1*0602 haplotype was reported to accelerate the T cell immune response to P. gingivalis (Takashiba et al 1999).…”

Section: Discussionmentioning

confidence: 86%

Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease

et al. 2007

View full text Add to dashboard Cite

Buerger disease (BD) is an occulusive vascular disease of unknown etiology. Although cigarette smoking is a well-known risk factor of BD, genetic factors may also play a role in the etiology. Because chronic bacterial infection such as oral periodontitis is suggested to be involved in the pathogenesis of BD, gene polymorphisms involved in the infectious immunity might be associated with BD as the genetic factor(s). We have previously reported that HLA-DRB1*1501 and B54 was associated with BD in Japanese. In this study, polymorphisms in HLA-DPB1, DRB1 and B were analyzed in 131 Japanese BD patients and 227 healthy controls. In addition, we investigated a functional promoter polymorphism, -260 C > T, of CD14 that is a main receptor of bacterial lipopolysaccharide. It was found that the frequencies of CD14 TT genotype [37.4 vs. 24.2%, P = 0.008 OR = 1.87, 95% confidence interval (CI); 1.18, 2.97], DRB1*1501 (34.4 vs. 13.2%, P (c) = 4.4 x 10(-5), OR = 3.44, 95%CI; 2.06, 5.73) and DPB1*0501 (79.4 vs. 55.1%, P (c) = 4.7 x 10(-5), OR = 3.14, 95%CI; 1.93, 5.11) were significantly higher in the patients than in the controls, demonstrating that at least three genetic markers were associated with BD. Stratification analyses of these associated markers suggested synergistic roles of the genetic factors. Odds ratios ranged from 4.72 to 12.57 in individuals carrying any two of these three markers. These findings suggested that the susceptibility to BD was in part controlled by genes involved in the innate and adaptive immunity.

show abstract

Section: Discussionmentioning

confidence: 86%

Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease

et al. 2007

View full text Add to dashboard Cite

show abstract

“…HLA-A*24(9), HLA-B*35, DRB1*04 and DR51 showed higher frequency in our PLS patients than in controls, but the differences were not statistically significant. HLA-A*24(9) DRB1*04 and DR51 alleles have been associated with different kinds of periodontitis in other countries [33,51-53]. …”

Section: Discussionmentioning

confidence: 99%

Identification of novel mutation in cathepsin C gene causing Papillon-Lefèvre Syndrome in Mexican patients

et al. 2013

View full text Add to dashboard Cite

BackgroundPapillon-Lefèvre Syndrome (PLS) is a type IV genodermatosis caused by mutations in cathepsin C (CTSC), with a worldwide prevalence of 1–4 cases per million in the general population. In México, the prevalence of this syndrome is unknown, and there are few case reports. The diagnosis of twenty patients in the state of Sinaloa highlights the need to characterize this syndrome in Mexicans.MethodsTo understand the basis of PLS in Mexicans, the gene expression, enzymatic activity and mutational analysis of CTSC were assayed in nine PLS patients and their relatives. Frequencies of CTSC gene polymorphisms and HLA alleles were determined in these patients, their relatives, and the population.ResultsPatients showed normal CTSC gene expression, but a deep reduction (up to 85%) in enzymatic activity in comparison to unrelated healthy individuals. A novel loss-of-function mutation, c.203 T >; G (p.Leu68Arg), was found in all patients, and some carried the polymorphism c.458C >; T (p.Thr153Ile). Allelic frequencies in patients, relatives and controls were 88.89%, 38.24% and 0.25% for G (c.203 T >; G); and 11.11%, 8.82% and 9.00% for T (c.458C >; T). HLA-DRB1*11 was found significantly more frequent (P = 0.0071) in patients than controls (33.33% vs. 7.32%), with an estimated relative risk of 6.33.ConclusionsThe novel loss-of function mutation of CTSC gene (c.203 T >; G) found in patients correlated with their diminished enzymatic activity, and HLA-DRB1*11 was found to be associated with PLS. The study of more PLS patients may give more insights into the etiology of the disease as well as its prevalence in México.

show abstract

“…HLA-9 ve HLA-15 antijenlerinin agresif periodontitisle ilişkili olduğu gösterilmiştir. 5,27 Yapılan başka bir calışmada HLA class I, HLA class II antijenleri ile periodontal hastalık arasında ilişki olduğunu gösterilmiştir. 28 Agresif periodontitis ile HLA-A2 ve HLA-B5 arasında ise negatif ilişki vardır.…”

Section: Agresi̇f Peri̇odonti̇ti̇s İçi̇n Ri̇sk Faktörleri̇ 1 Mikrobiyolojikunclassified

Aggressive Periodontitis

大澤¹,

仲谷²,

鴨井³

2018

Diseases and Conditions in Dentistry

View full text Add to dashboard Cite

Are there HLA combinations typical supporting for or making resistant against aggressive and/or chronic periodontitis?

Cited by 45 publications

References 34 publications

Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease

Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease

Identification of novel mutation in cathepsin C gene causing Papillon-Lefèvre Syndrome in Mexican patients

Aggressive Periodontitis

Contact Info

Product

Resources

About