Pharmacoepidem. Drug Safe.
 1996
DOI: 10.1002/(sici)1099-1557(199607)5:4<247::aid-pds220>3.0.co;2-i
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Are the Adverse Drug Reactions of Amoxycillin and Amoxycillin-Clavulanic Acid Similar?

Inocencia Martínez‐Mir
1
,
José M. Ferrer
2
,
V. Palop
3
et al.
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“…74,75 Whilst amoxicillin alone does not commonly cause iDILI, it does cause iDILI when given in combination with clavulanic acid. 76 A role for the adaptive immune system is also supported by studies linking co-amoxiclav hypersensitivity with a number of HLA class II alleles, particularly the HLA DRB1*15:01 and HLA DQB1*06:02 haplotype. 11,31,34 One study has linked specific haplotypes with specific clinical symptoms of iDILI: the DRB1*15:01/DQB1*06:02 haplotype with cholestatic iDILI and the HLA A*30:02/HLA B*18:01 haplotype with hepatocellular iDILI.…”
Section: Co-amoxiclavmentioning
confidence: 98%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…74,75 Whilst amoxicillin alone does not commonly cause iDILI, it does cause iDILI when given in combination with clavulanic acid. 76 A role for the adaptive immune system is also supported by studies linking co-amoxiclav hypersensitivity with a number of HLA class II alleles, particularly the HLA DRB1*15:01 and HLA DQB1*06:02 haplotype. 11,31,34 One study has linked specific haplotypes with specific clinical symptoms of iDILI: the DRB1*15:01/DQB1*06:02 haplotype with cholestatic iDILI and the HLA A*30:02/HLA B*18:01 haplotype with hepatocellular iDILI.…”
Section: Co-amoxiclavmentioning
confidence: 98%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…A moxicillin-clavulanate (AC) has become one of the most widely prescribed antibiotics 1 and, although the penicillin variants are considered relatively safe, adverse reactions such as those in the gastrointestinal tract can occur more frequently with this combination. 2 Several reports incriminate AC in the development of cholestatic hepatitis. [3][4][5][6][7] Yet despite the potentially serious adverse reactions, the sales of this antibiotic combination have increased steadily to become the leading antibiotics prescribed in Spain and other European countries.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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