Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study

Khademian, Majid; Ejtahed, Hanieh‐Sadat; Heshmat, Ramin; Motlagh, Mohammad Esmaeil; Vafaeenia, Mahya; Shafiee, Gita; Mahdivi-Gorabi, Armita; Qorbani, Mostafa; Kelishadi, Roya

doi:10.1186/s12944-018-0895-1

Cited by 10 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, all AUC values were in the range of 0.8–0.9 in both genders, suggesting that all atherogenic indices assessed in our study are useful for predicting MetS. Similar results of AUC values for TG/HDL-c index, although slightly lower that in our study, were obtained by Angoorani et al (2018b) in an Iranian population aged 7–18 years. Also, the cutoff points in that study were slightly lower than those reported here.…”

Section: Discussionsupporting

confidence: 87%

“…Also, the cutoff points in that study were slightly lower than those reported here. These differences might be explained by the fact that different MetS diagnostic criteria were employed, IDF in our study and the Adult Treatment Panel III (ATP III) criteria in the study of Angoorani et al (2018b). We have previously suggested that there is a high variability in the existing criteria for the diagnosis of MetS in adolescents (Fernández-Aparicio et al, 2021) and that the IDF’s diagnostic criteria are the most accurate for the prediction of MetS in adolescents using anthropometric indices (Perona et al, 2019).…”

Section: Discussionmentioning

confidence: 93%

“…These authors also showed an association between non-HDL cholesterol and the development of MetS. Nevertheless, the authors suggested the need to contrast these findings with new studies in ethnically and geographically different populations (Angoorani et al, 2018b). Dobiášová and Frohlich (2001) indicated that the AIP constitutes an important marker in the evaluation of the risk of coronary artery disease (CAD), suggesting its use in clinical practice as an alternative marker of plasma atherogenesis.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Assessment of Different Atherogenic Indices as Predictors of Metabolic Syndrome in Spanish Adolescents

Fernández-Aparicio

Perona

Padez

et al. 2021

Biological Research For Nursing

View full text Add to dashboard Cite

Background: Inconsistent results due to age, ethnic, and geographic differences have been found on the predictive capacity of atherogenic indices in previous studies. The aim of this study was to assess the predictive value of 6 atherogenic indices for MetS in a Spanish adolescent population. Methods: A cross-sectional study was performed on 981 adolescents (13.2 ± 1.2y) that were randomly recruited from schools in Southeastern Spain. Anthropometric and biochemical parameters were evaluated to identify the presence of MetS. The following atherogenic indices were calculated: triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), non-HDL cholesterol, triglycerides to HDL-cholesterol ratio (TG/HDL-c), LDL-cholesterol to HDL-cholesterol ratio (LDL-c/HDL-c), and total cholesterol to HDL-cholesterol ratio (TC/HDL-c). Results: The area under the curve (AUC) of receiver operating characteristic curves was used for discrimination purposes. AIP was the atherogenic index most strongly associated with MetS with an unadjusted odds ratio (OR) of 37.98 in boys and of 28.75 in girls. A high OR was maintained after adjustment by different factors. AUC values for all atherogenic indices were above 0.83 and 0.88 in boys and in girls, respectively. Conclusions: Among the 6 atherogenic indices studied, AIP was the one most strongly associated with MetS in Spanish adolescents. The AUC values obtained from ROC analyses suggest that all atherogenic indices have the ability to predict MetS. These atherogenic indices are interesting and useful predictive indicators for MetS. However, more studies are needed to explore in-depth this predictive capacity.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 99%

See 1 more Smart Citation

Assessment of Different Atherogenic Indices as Predictors of Metabolic Syndrome in Spanish Adolescents

Fernández-Aparicio

Perona

Padez

et al. 2021

Biological Research For Nursing

View full text Add to dashboard Cite

show abstract

“…After the rejection of duplicates, we screened 415 studies, followed by a full-text assessment for eligibility for 222 papers. Finally, 19 ( 20 – 38 ) and 5 ( 20 , 25 , 27 , 29 , 31 ) studies were included in the qualitative and quantitative syntheses, respectively. The detailed flow diagram is demonstrated in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Is non-high-density lipoprotein associated with metabolic syndrome? A systematic review and meta-analysis

Mardi

Abdi²,

Ehsani³

et al. 2022

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

IntroductionNovel atherogenic lipid indices, including non-high-density lipoprotein cholesterol (non-HDL-C) which is calculated by subtracting the HDL-C value from the total cholesterol level, atherogenic index (ratio between triglycerides (TG) and HDL-C concentrations (TG/HDL-C)), and Diff-C (calculated by subtracting low-density lipoprotein (LDL-C) from non-HDL-C), have been known as valuable predictors of dyslipidemia and subsequent cardiovascular diseases. Previous studies have reported the potential association of novel atherogenic lipid indices with metabolic syndrome (MetS). This meta-analysis aimed to assess the pooled association of novel atherogenic lipid indices with MetS or its components.MethodsA systematic search was conducted through PubMed, Scopus, and Web of Science (WoS) databases from January 2000 until March 2021 to evaluate the association of novel atherogenic lipid indices, including non-HDL-C, atherogenic index, and the difference between non-HDL-C and LDL-C (Diff-C) with MetS. Observational studies were included without any language restriction. As exclusive studies evaluating the association of non-HDL-C with metabolic syndrome (MetS) were eligible to be included in quantitative analyses, a random-effect meta-analysis was performed to pool the odds ratios (ORs). A stratified meta-analysis was performed based on the definition of MetS [Adult Treatment Panel (ATP) and International Diabetes Federation (IDF)] and the studied population.ResultsOverall, 318 studies were retrieved from an initial systematic search. After screening, 18 and five studies were included in the qualitative and quantitative syntheses, respectively. Qualitative synthesis revealed an association between non-HDL-C, Diff-C, and atherogenic index with MetS and its components. Stratified meta-analysis showed that an increased non-HDL-C level was associated with an increased odds of MetS based on ATP criteria (OR: 3.77, 95% CI: 2.14-5.39) and IDF criteria (OR: 2.71, 95% CI: 1.98-3.44) in adults (OR: 3.53, 95% CI: 2.29-4.78) and in children (OR: 2.27, 95% CI: 1.65-2.90).ConclusionNovel atherogenic lipid indices, including atherogenic index, Diff-c, and non-HDL-C, are strongly associated with increased odds of MetS and its components. The indices could be considered as potential predictors of MetS and its components in clinical practice.

show abstract

“…Given the long latency period between tobacco exposure and AS, the identi cation of sensitive bio-markers of dyslipidemia is important for assessment of potential AS 22 . Several studies have recommended the use of non-HDL-C as a valuable predictor for dyslipidemia and cardiovascular risks 23,24 . In the current study, we demonstrated that tobacco actively exposed (current smoking), smoking intensity and burden were all positively associated with higher levels of the AS bio-marker non-HDL-C in the general adult population in Beijing, even after adjusting for several parameters that might affect the result.…”

Section: Discussionmentioning

confidence: 99%

Association Between Self-Reported Tobacco Smoke Exposure and Serum Non-High-Density Lipoprotein Among Adults, Beijing

Wei

Fang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Cigarette smoking, including secondhand exposure, is a leading cause of several atherosclerotic diseases (AS). Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and AS. There is a need to identify the association of tobacco smoke exposure (TSE) and the marker of sub-clinical AS.Objective: To examine the association of TSE, including exposed status, cigarette smoking intensity and burden with serum non-HDL-C level.Methods: A cross-sectional study was carried out on 18-79 years old residents in 2017 in Beijing. All participants were interviewed on their tobacco exposed status (unexposed, passively exposed, actively exposed), smoking intensity (number of cigarettes smoked per week) and smoking burden (pack-years of smoking) among current smokers. Non-HDL-C was calculated by subtracting high density lipoprotein cholesterol (HDL-C) from total cholesterol (TC). Covariates were age, education status, alcohol drinking status within 30 days, hypertension, type 2 diabetes, physical inactivity and BMI. We plot graphs to show the tendency between the number of cigarettes smoked per week, passively exposed days per week and non-HDL-C levels, respectively. Multiple regression models were used to assess the association between non-HDL-C level and TSE after the adjustment for covariates. Results: Of the 12,798 participants, mean age was 44.9±15.4 years, 46.8% were male. The prevalence of actively exposed, passively exposed and unexposed to tobacco smoke was 25.7%, 35.7% and 38.6%, respectively. Of the tobacco passively exposed subjects, 21.7% had to exposed to second-hand smoke every day. Among current smokers, 41.2% were smoking more than 120 cigarettes per week, and 56.6% were smoking more over 20 pack-years. With the increasing of the number of cigarettes smoked per week, the serum level of non-HDL-C in male increased gradually (Male: F=2.83, P=0.04; Female: F=1.23, P=0.32; Total: F=3.29, P=0.02). After multivariable adjustment, smokers had a higher non-HDL-C level (OR=1.34, 95%CI: 1.20,1.59, P=0.001) compared with tobacco unexposed subjects. However, passively smokers were not associated with non-HDL-C levels regardless of gender (OR=0.98, 95%CI: 0.78,1.23, P=0.87). Compared with lighter smokers, male smokers who smoked more than 140 cigarettes per week had significantly higher non-HDL-C levels (OR=1.30, 95%CI: 1.00,1.70, P=0.04). Male higher burden smokers (>20 pack-years) had more risk of having higher non-HDL-C level (OR=1.88, 95%CI: 1.46,2.43, P<0.001) compared with other smokers. However, there were no significant differences between non-HDL-C and smoking intensity or burden among female smokers.Conclusions: This study showed that strong associations between TSE and non-HDL-C levels, especially in male smokers. Findings of this work emphasize the importance of encouragement to focus on blood lipid levels among smokers.

show abstract

Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study

Cited by 10 publications

References 39 publications

Assessment of Different Atherogenic Indices as Predictors of Metabolic Syndrome in Spanish Adolescents

Assessment of Different Atherogenic Indices as Predictors of Metabolic Syndrome in Spanish Adolescents

Is non-high-density lipoprotein associated with metabolic syndrome? A systematic review and meta-analysis

Association Between Self-Reported Tobacco Smoke Exposure and Serum Non-High-Density Lipoprotein Among Adults, Beijing

Contact Info

Product

Resources

About