Are neutrophil-, eosinophil-, and basophil-to-lymphocyte ratios useful markers for pinpointing patients at higher risk of recurrent sinonasal polyps?

Brescia, Giuseppe; Pedruzzi, Barbara; Barion, Umberto; Cinetto, Francesco; Giacomelli, Luciano; Martini, Alessandro; Marioni, Gino

doi:10.1016/j.amjoto.2016.02.002

Cited by 55 publications

(51 citation statements)

References 18 publications

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“…The present series included the patients investigated in a previous study . The studies differ in several key ways: (1) cohort considered (40 new cases of CRSwNP were added in the present one); (2) clinical follow‐up periods of the previously considered cohort (mean follow‐up period 32.7 ± 12.1 vs 30.3 ± 12.2 months; 3 new CRSwNP recurrences occurred in this period); (3) endpoints (in the previous investigation the clinical role of the neutrophil‐to‐lymphocyte ratio, eosinophil‐to‐lymphocyte ratio, and basophil‐to‐lymphocyte ratio was analyzed); and (4) statistical approach to results (ORs [recurrence vs variable] with exact CIs calculation in the present study vs ratios’ discriminatory power in terms of CRSwNP recurrence assessed on the Hosmer and Lemeshow scale in the previous one).…”

Section: Resultsmentioning

confidence: 99%

“…A recent preliminary investigation conducted by our own research group also showed a significant direct association between CRSwNP recurrence rates and serum basophil counts . When the neutrophil‐to‐lymphocyte ratio (NLR) was investigated vis‐a‐vis CRSwNP recurrence after surgery, it was found to be significant higher in patients whose disease recurred than in those remaining disease‐free . Yenigün also found that patients with recurrent polyposis had a significantly higher preoperative eosinophil‐to‐lymphocyte ratio (ELR) than patients remaining recurrence‐free.…”

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confidence: 88%

“…Subsequently, there is a need for effective prognostic parameters that would enable rhinologists to earmark patients at higher risk of recurrent CRSwNP after ESS. Such parameters would help to provide each patient with appropriate information, a rational follow‐up, and postoperative medical treatment tailored to their actual recurrence risk …”

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confidence: 99%

“…Yenigün also found that patients with recurrent polyposis had a significantly higher preoperative eosinophil‐to‐lymphocyte ratio (ELR) than patients remaining recurrence‐free. Recently, our research group was the first to test the prognostic value of the basophil‐to‐lymphocyte ratio (BLR) (given the emerging role of basophils in CRSwNP), which was again significantly higher in patients whose disease recurred after surgery. Basophils are traditionally perceived, together with mast cells, as the typical innate effector cells of allergen‐induced immunoglobulin E (IgE)‐dependent diseases.…”

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confidence: 99%

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The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Brescia

Barion

Zanotti

et al. 2016

Int Forum Allergy Rhinol

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Section: Resultsmentioning

confidence: 99%

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confidence: 88%

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confidence: 99%

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confidence: 99%

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The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Brescia

Barion

Zanotti

et al. 2016

Int Forum Allergy Rhinol

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“…Although there are many studies on their correlations with disease severity and recurrence in nasal polyposis cases, it is noted that the two most commonly associated values in this respect are ELR and NLR. 11,24 The studies showed that PLR was more valuable than NLR in chronic inflammation, and it has been emphasized that PLR is an important inflammation marker. 9,25 Furthermore, there are also studies suggesting that PLR is a predictive marker in nasal polyposis cases.…”

Section: Discussionmentioning

confidence: 99%

Do Blood Cell Parameters have a Predictive Role in the Etiology and Severity Pediatric Antrochoanal Polyp Cases?

Korkmaz

Çelik

Turan

et al. 2020

Int Arch Otorhinolaryngol

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Introduction There are no definitive parameters to guide the etiology and severity of pediatric antrochoanal polyps. Objective The aim of our study is to compare the values of blood cell distribution parameters in cases of pediatric antrochoanal polyps (ACPs) with those of the control group. These values may be guiding parameters in determining the etiology of ACPs and evaluating the severity of the disease and the risk of recurrence. Methods Blood count values of patients operated for pediatric ACPs were retrospectively analyzed and compared with the data of the control group with the same age and gender distribution. The ACPs group was divided into subgroups in terms of inflammation, severity, and recurrence, and these subgroups were statistically compared as well. Results When the ACP patient group and the control group were compared, there was no statistically significant difference between the two groups. When we compared the patients considering the CT findings, there was a statistically significant difference between the stage III patients and the control group in terms of mean platelet volume (MPV) and platelet-to-lymphocyte ratio (PLR) values (p < 0.05 in both). Similarly, the MPV and PLR values were significantly higher in the recurrence patient group than in the control group. (p < 0.05 in both). Conclusion As a result of the data obtained, it can be suggested that inflammatory parameters in pediatric cases of ACPs vary in terms of recurrence and the severity of the disease.

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Highlights of eosinophilic chronic rhinosinusitis with nasal polyps in definition, prognosis, and advancement

Lou

Zhang

Bachert

et al. 2018

Int Forum Allergy Rhinol

162

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BackgroundTissue eosinophils are characteristic of inflammation in most but not all patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and may be useful for defining subgroups and making treatment choices. However, no consistent diagnostic criteria for CRSwNP with eosinophilic inflammation have been established.MethodsRelated literature review was performed and current developments in the diagnosis of eosinophilic CRSwNP were summarized. Details in histopathology, definition of tissue eosinophilia, eosinophil as an indicator of disease recurrence, eosinophilic shift, and related biomarkers in CRSwNP are included in this review article.ResultsMucosal eosinophilia exhibits significant geographic and ethnic differences and may increase over time. Tissue eosinophilia can be defined using a cutoff value based on reference values from healthy mucosa, but typical disease‐specific values should also be employed to increase sensitivity and specificity for clinical use. Recent developments highlight the diagnostic criteria for eosinophilic CRSwNP based on cluster analysis, which were also associated with clinical outcomes. Additionally, some promising eosinophil‐relevant biomarkers, such as eosinophilic cation protein and interleukin 5 (IL‐5), may be clinically applied as diagnostic or predictive tools for CRSwNP in the future.ConclusionSinonasal tissue eosinophilia is present in a majority of CRSwNP patients but is currently more common in the West than in the East. Cutoff values of eosinophils as the diagnostic criteria of eosinophilic CRSwNP are subject to change with geographic and ethnic differences over time. It will be important to identify validated eosinophil‐related biomarkers in different continents/countries for future research and for the introduction of precision medicine.

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Are neutrophil-, eosinophil-, and basophil-to-lymphocyte ratios useful markers for pinpointing patients at higher risk of recurrent sinonasal polyps?

Cited by 55 publications

References 18 publications

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis

Do Blood Cell Parameters have a Predictive Role in the Etiology and Severity Pediatric Antrochoanal Polyp Cases?

Highlights of eosinophilic chronic rhinosinusitis with nasal polyps in definition, prognosis, and advancement

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