Are Methylenetetrahydrofolate Reductase (&amp;lt;i&amp;gt;MTHFR&amp;lt;/i&amp;gt;) Gene Polymorphisms C677T and A1298C Associated with Higher Risk of Pediatric Migraine in Boys and Girls?

Lorenz, Anna-Liisa; Kahre, Tiina; Mihailov, Evelin; Nikopensius, Tiit; Lotman, Eno-Martin; Metspalu, Andres; Kolk, Anneli

doi:10.4236/jbise.2014.78049

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…also confirmed that this MTHFR genotype is associated with specific clinical variables of migraine. Other studies confirmed that genetic variants of C677T can increase the risk for developing migraine with and without aura . The frequency of C677T in the genesis of migraine was recently confirmed in pediatric migraine too .…”

Section: Hcy‐related Migrainementioning

confidence: 79%

“…Other studies confirmed that genetic variants of C677T can increase the risk for developing migraine with and without aura. 3,4,[23][24][25] The frequency of C677T in the genesis of migraine was recently confirmed in pediatric migraine too. 22 Thus, a significant association between HHcy caused by MTHFR C677T polymorphism and migraine exists, even if the specific role of this gene variant in the migraine pathogenesis remained unexplained.…”

Section: Hcy-related Migrainementioning

confidence: 99%

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Migraine homocysteine‐related: Old and new mechanisms

Cacciapuoti

2017

Neurology & Clinical Neurosc

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In this review, we discussed how homocysteinemia can induce migraine. Vascular and neurogenic mechanisms of migraine-onset, such as the classical "triggers", were examined. Favourable effects induced on the syndrome by folate supplementation were also illustrated. However, it was recently shown that hyper-homocysteinemia can favor migraine by the production of homocysteic acid.This acts as an agonist of the N-acetyl-aspartame-D receptor, and is a potent neurotoxic stimulus causing migraine. Its detrimental effects seem to be antagonized by N-acetylcysteine, calcium chelators, a naturally-occurring dipeptide widely distribuited in the muscular and nervous systems. This compound showed positive results in animal models. Elevated homocysteic acid levels secondary to hyper-homocysteinemia could sensitize the dura mater and cerebral arteries and favor the activation of the trigeminovascular system, predisposing to migraine attacks. However, other experimental and human studies are requested to ratify the negative effect of homocysteic acid on migraine and the positive results obtaining with of its antagonists.

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Section: Hcy‐related Migrainementioning

confidence: 79%

Section: Hcy-related Migrainementioning

confidence: 99%

Migraine homocysteine‐related: Old and new mechanisms

Cacciapuoti

2017

Neurology & Clinical Neurosc

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“…There are some data showing that the 677C>T polymorphism in the MTHFR gene may be related to an especially high risk of AIS in boys in Polish population in comparison with girls [34]. In contrast, higher, although not significant, prevalence of the 677T allele was observed in girls with migraine (with aura or without aura) when compared to boys [35]. Unfortunately, none of the studies included to the present meta-analysis show full data of genotype distribution; thus, we were not able to analyse sex subgroups to observe whether a similar relationship concerns the 1298A>C polymorphism.…”

Section: Discussionmentioning

confidence: 94%

Is the 1298A>C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis

2018

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An elevated level of homocysteine is a risk factor for vascular diseases, brain atrophy and several other disorders. The 1298A>C polymorphism (rs1801131) leads to mildly decreased MTHFR activity. Previously, it was observed that the MTHFR 1298A>C polymorphism in combined analysis with the MTHFR 677C>T polymorphism increases homocysteine levels. However, conflicting results on its relation to ischaemic stroke in children can be found. We conducted a meta-analysis to analyse possible connections between the MTHFR 1298A>C polymorphism and ischaemic stroke in paediatric patients. We identified available data published before December 2016 using appropriate keywords and searching PubMed as well as the references cited in the found articles. Eight case-control studies were included in the meta-analysis (426 children with stroke and 778 controls). Statistical analyses were made using R and Comprehensive Meta-Analysis softwares to investigate the impact of polymorphism in four models: dominant, recessive, additive and allelic. No publication bias was observed in the meta-analysis. We demonstrated no relationship between the 1298A>C polymorphism and ischaemic stroke in children in the case of recessive, additive and allelic models. However, the results of the dominant model analysis should be treated with caution due to the sensitivity analysis results. After omitting one of the included study, we observed a significant association between the carriers of the MTHFR C allele (cases with AC + CC genotypes) and ischaemic stroke in children (OR 1.35 95% CI 1.02-1.79, p = 0.035 in a fixed effects model). In conclusion, the 1298A>C polymorphism in the MTHFR gene is not a risk factor for ischaemic stroke in paediatric patients.

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“…Gender-based differences in the distribution of the polymorphisms observed in the present study may be attributed to selective pressure differential recombination rates [36] between the genders. Such gender-based differences in the frequencies of various polymorphisms have been reported [37,38].…”

Section: Discussionmentioning

confidence: 94%

Susceptibility to oral cancers with CD95 and CD95L promoter SNPs may vary with the site and gender

et al. 2015

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We investigated risk association of oral cancers (tongue and buccal mucosa cancers) with FAS (-1377G > A and FAS -670 A > G) and FASL (-844 T > C) SNPs, in males and females. A case-control study of 535 oral cancer and 525 control subjects was performed. SNPs were detected in the genomic DNA isolated from peripheral blood using PCR-RFLP. We report FASL -844 T > C SNPs increased risk for buccal mucosa cancer in females but not in males. On the other hand, FAS genotypes did not alter the risk of the cancers in both females and males. However, co-occurrence of FAS -1377 GA and -670 GG, FAS -1377 AA and -670 GG genotypes, and combined genotypes of FAS and FASL (FAS -1377 AA + FAS -670 GG + FASL -844 CC) alter male susceptibility towards tongue cancer. In females, combined genotypes of FAS (-1377GA and -670 AA) were found to be a risk factor of buccal mucosa cancer (OR = 3.27, CI = 1.28-8.36; P ≤ 0.01). FASL variants (GA and AA) increased tongue cancer risk in females who were tobacco users compared to non-tobacco users. In conclusion, SNPs of the FAS and FASL might alter risk of tongue and buccal mucosa cancers differentially, in a gender-dependent manner.

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Are Methylenetetrahydrofolate Reductase (<i>MTHFR</i>) Gene Polymorphisms C677T and A1298C Associated with Higher Risk of Pediatric Migraine in Boys and Girls?

Cited by 10 publications

References 34 publications

Migraine homocysteine‐related: Old and new mechanisms

Migraine homocysteine‐related: Old and new mechanisms

Is the 1298A>C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis

Susceptibility to oral cancers with CD95 and CD95L promoter SNPs may vary with the site and gender

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