Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Lesiak, Aleksandra; Bednarski, Igor; Pałczyńska, Marta; Kumiszcza, Ewelina; Kraska-Gacka, Marzena; Woźniacka, Anna

doi:10.5114/ada.2016.62838

Cited by 16 publications

(12 citation statements)

References 24 publications

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“…Swedish studies have shown a high prevalence of antigliadin and anti-tissue transglutaminase antibodies, coeliac disease, and disturbed calcium homeostasis in patients with PPP [3,6,28]. However, a study in German and Polish populations did not confirm these observations, and these laboratory tests are not routinely performed in patients with PPP in our clinical practice [7,29,30].…”

Section: Coeliac Diseasementioning

confidence: 98%

“…Lesiak et al [29] found elevated levels of IL-15 and IL-22 in the sera of female patients with PPP. We know that IL-15 induces IL-17 production and IL-22 enhances the proinflammatory action of IL-17 [29].…”

Section: Interleukin (Il)-17 Pathwaymentioning

confidence: 99%

“…IL-17 is produced by not only T-helper type 17 (Th17) cells but also by neutrophils and mast cells [63]. Lesiak et al [29] found elevated levels of IL-15 and IL-22 in the sera of female patients with PPP. We know that IL-15 induces IL-17 production and IL-22 enhances the proinflammatory action of IL-17 [29].…”

Section: Interleukin (Il)-17 Pathwaymentioning

confidence: 99%

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Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

2020

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Palmoplantar pustulosis (PPP) is a chronic, recurrent skin disease belonging to the spectrum of psoriasis. It is characterized by an eruption of sterile pustules on the palms and soles. Recent studies in PPP have focused on genetic differences between pustular phenotypes and the role of the innate immunological system and the microbiome in the etiopathogenesis of the disease. Mutations in IL36RN (a major predisposing factor for generalized pustular psoriasis) were found in selected patients with PPP and were associated with earlier disease onset. Studies have shown that the interleukin (IL)-17 and IL-36 pathways might be involved in the pathogenesis of PPP. A microbiome has been demonstrated in the vesicopustules of PPP, and an abundance of Staphylococcus appears to be increased by smoking. Improved understanding of the underlying etiopathogenesis of PPP has led to advances in treatment options, and targeted therapies for PPP have been evaluated or are under evaluation against more than 12 molecules in ongoing clinical trials.

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Section: Coeliac Diseasementioning

confidence: 98%

Section: Interleukin (Il)-17 Pathwaymentioning

confidence: 99%

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Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

2020

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“…Its expression in acute atopic dermatitis is decreased,[17] whereas it is highly expressed in psoriatic plaques[18] and in pustular palmoplantar psoriasis. [19]…”

Section: Discussionmentioning

confidence: 99%

Serum interleukin-15 is a marker of alopecia areata severity

et al. 2019

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Background: Interleukin-15 (IL-15) is a cytokine that is involved in many inflammatory and autoimmune diseases. Although alopecia areata (AA) is an autoimmune disease, serum levels of IL-15 have not been studied well in AA patients. Aim of the Work: We aims at evaluating the serum levels of IL-15 in active AA. Subject and Methods: This case-control study included 40 AA patients and 40 apparently healthy matched controls. Written informed consents were obtained from all the participants. The scalp was examined to assess sites, number, and size of alopecia patches, and the severity of AA lesions was assessed using the Severity of Alopecia Tool score (SALT score) which determine the percentage of hair loss in the scalp. The body was carefully examined to detect any alopecia patches in any hairy area. Nail examination was carried out to detect any nail involvement. Serum IL-15 levels were measured using an ELISA kits. Results: Serum levels of IL-15 in patients were significantly higher than those in the control group ( P < 0.001). Serum levels in alopecia totalis were significantly higher than those with one or two patches, and serum levels in patients with both scalp and body involvement were significantly elevated than the levels of patients with either scalp or body involvement. There was a statistically significant positive correlation between SALT score and serum levels of IL-15 ( P < 0.001). Conclusion: Serum IL-15 may be a marker of AA severity.

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“…IL-15 has similar biological effects as IL-2, however, distinct key roles were identified during development and function of CD8+ T cells, natural killer cells, invariant natural killer-T cells, and intestinal intraepithelial lymphocytes (Castillo and Schluns, 2012). High serum levels of IL-15 were implicated in the pathogenesis of pustular palmoplantar psoriasis (Lesiak et al, 2016), which is an infrequent type of psoriasis disturbing primarily distal parts of the limbs. Likewise, higher levels of IL-15 were correlated with the activity of NK cells in the pathogenesis of psoriatic arthritis (Tang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Pemphigus foliaceus patients (Fogo Selvagem) treated with kinesiotherapy presented lower levels of proinflammatory cytokines

et al. 2019

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Fogo Selvagem (FS) is a rare autoimmune disease characterized by acantholysis and inflammation of the epidermis. It was evidenced in this disease the increase of proinflammatory cytokines levels which can be influenced by physical activities. Kinesiotherapy, as physiotherapeutic interventions, was associated improvement levels of the quality of live, mainly the pain. Understanding the impact of such methodology in immunology of the FS, may constitute an alternative and effective approach. We compare the levels of serum cytokines and chemokines between nine patients with FS submitted to kinesiotherapy for 12 weeks and ten patients not submitted to kinesiotherapy. The kinesiotherapy was composed by self-stretching followed by a resistance training for upper and lower limbs. The protocol was carried out in three sections of eight to ten repetitions with 70% of the maximum load measured by test maximum of ten repetitions. After strengthening period patients performed a passive stretching. The training sessions lasted 50 min and were performed 3 times a week at least 12 weeks. Cytokines and chemokines were assessed in plasma using enzyme-linked immunosorbent assay and/or cytometric bead array. Patients with FS were being kinesiotherapy presented minors levels of interferon-γ, interleukin (IL)-17, IL-22, and IL-15 when compared to those not submitted to kinesiotherapy. No differences were observed for the detection of the chemokines chemokine ligand (CCL)-2, CCL-3, CCL-5, CCL-11, C-X-C motif chemokine 8 (CXCL-8), and CXCL-10. These results suggest that kinesiotherapy had a positive impact on inflammatory markers that are associated with disease worsening in FS.

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Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Cited by 16 publications

References 24 publications

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

Palmoplantar Pustulosis: Recent Advances in Etiopathogenesis and Emerging Treatments

Serum interleukin-15 is a marker of alopecia areata severity

Pemphigus foliaceus patients (Fogo Selvagem) treated with kinesiotherapy presented lower levels of proinflammatory cytokines

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