Are gelatin-containing vaccines safe to give in alpha-gal sensitized patients?

Zafar, Saira; Wolff, A.; Schutzer, Steven E.; McGintee, Erin; Torre, A. Concha

doi:10.1016/j.jaci.2021.12.348

Cited by 1 publication

(1 citation statement)

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“…Challenges of using natural polymers such as the risk of anaphylaxis reactions in gelatin-based vaccines, especially in patients with alpha-gal-sensitization. Alpha-gal syndrome induces IgE sensitization [ 139 ] towards carbohydrate galactose-α-1,3-galactose (alpha-gal), usually observed in gelatin products [ 140 ]. Gelatin-encompassing vaccines for diseases such as zoster, varicella, mumps, measles, and rubella in patients who possess alpha-gal syndrome showed positive basophil activation test (BAT) (i.e., indicates possible anaphylaxis reaction) [ 141 ].…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Nordin

Husna

Ahmad

et al. 2023

Gels

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A key element in ensuring successful immunization is the efficient delivery of vaccines. However, poor immunogenicity and adverse inflammatory immunogenic reactions make the establishment of an efficient vaccine delivery method a challenging task. The delivery of vaccines has been performed via a variety of delivery methods, including natural-polymer-based carriers that are relatively biocompatible and have low toxicity. The incorporation of adjuvants or antigens into biomaterial-based immunizations has demonstrated better immune response than formulations that just contain the antigen. This system may enable antigen-mediated immunogenicity and shelter and transport the cargo vaccine or antigen to the appropriate target organ. In this regard, this work reviews the recent applications of natural polymer composites from different sources, such as animals, plants, and microbes, in vaccine delivery systems.

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Section: Challenges and Future Perspectivesmentioning

confidence: 99%