Are Exercise Benefits in Nonalcoholic Fatty Liver Disease Due to Increased Autophagy?

Dasarathy, Srinivasan

doi:10.1249/jes.0000000000000118

Cited by 5 publications

(2 citation statements)

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“…Indeed, decreased autophagy and associated endoplasmic reticulum stress were reported in murine genetic and dietary models of obesity [78,79], as well as in NAFLD-diagnosed patients, dietary NAFLD murine model and in vitro human hepatic cells [80]. The finding that autophagy is involved in breakdown of lipid droplets in liver cells suggests that autophagy impairments may have a critical role in the pathogenesis of NAFLD [78], which supports the role of physical activity as an important tool in the prevention of NAFLD through autophagy promotion [81,82].…”

Section: Mitochondrial Network Failure In Nafldmentioning

confidence: 93%

“…These results highlight the relevance of active lifestyle strategies to reduce the susceptibility of liver mitochondria to permeability transition pore opening and to positively modulate apoptotic and autophagic signaling in animal models of NAFLD [53]. Even tough, it is important to note that, in some circumstances related with the severity of the deleterious consequences, physical exercise may also stimulates autophagy in various tissues, including liver [82,144], suggesting that one of the mechanisms through which exercise could induce its beneficial effects is the activation of the autophagic signalling [81].…”

Section: Physical Exercise and Liver Mitochondrial Adaptationsmentioning

confidence: 99%

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Physical exercise and liver “fitness”: Role of mitochondrial function and epigenetics-related mechanisms in non-alcoholic fatty liver disease

Stevanović

Beleza

Coxito

et al. 2020

Molecular Metabolism

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BackgroundModern lifestyles, especially high-caloric intake and physical inactivity, contribute to the increased prevalence of non-alcoholic fatty liver disease (NAFLD), which becomes a significant health problem worldwide. Lifestyle changes, however, affect not only parental generation, but also their offspring, reinforcing the need for efficient preventive approaches to deal with this disease. This transgenerational influence of phenotypes dependent on parents (particularly maternal) behaviours may open additional research avenues. Despite persistent attempts to design an effective pharmacological therapy against NAFLD, physical activity, as a non-pharmacological approach, emerges as an exciting strategy.Scope of ReviewHere we briefly review the effect of physical exercise on liver mitochondria adaptations in NAFLD, highlighting the importance of mitochondrial metabolism and transgenerational and epigenetic mechanisms in liver diseases.Major ConclusionsA deeper look into cellular mechanisms sheds a light on possible effects of physical activity in the prevention and treatment of NAFLD through modulation of function and structure of particular organelles, namely mitochondria. Additionally, despite of increasing evidence regarding the contribution of epigenetic mechanisms in the pathogenesis of different diseases, the role of microRNAs, DNA methylation, and histone modification in NAFLD pathogenesis still needs to be elucidated.

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