Are collagens the culprits in the development of incisional and inguinal hernia disease?

Klinge, U.; Binnebösel, Marcel; Mertens, Peter R.

doi:10.1007/s10029-006-0145-8

Cited by 80 publications

(57 citation statements)

References 26 publications

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“…It has been proven previously that in patients affected by hernia the changes of tissue collagen are related to the occurrence of this disease [23]. Moreover, the study by Klinge et al revealed marked changes in the abundance and composition of interstitial collagens in patients with adult groin hernia and incisional hernia [24].…”

Section: Discussionmentioning

confidence: 95%

Evaluation of peritoneal tissue by means of differential scanning calorimetry (DSC)

Torres¹,

Trębacz²,

Chróścicki³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:Abdominal surgeries alter the integrity of the peritoneal layer and cause imbalances among immunological, inflammatory and angiogenic mechanisms within the tissue. During laparoscopic procedures a protective function of the peritoneal layer can be disturbed by the gas used to create a pneumoperitoneum. The aim of this study was to characterize peritoneal tissue by means of differential scanning calorimetry (DSC) as a reference for future investigations on the influence of surgical procedures on the physicochemical state of the peritoneum. Thirty-seven patients participated in the study. Patients were divided into three groups according to the type of surgery: group H -patients who underwent hernia repair; group Ch -patients who underwent laparoscopic cholecystectomy; and group C -patients operated due to rectal cancer. It was observed that onset temperature (T o ), denaturation temperature (T m ) and change of enthalpy (DH) during thermal denaturation of peritoneal collagen in were significantly different for these three groups of patients. The mean values of onset temperature (T o ) and denaturation temperature (T m ) in group H were significantly lower, while DH in this group was significantly higher than in the two other groups (Ch and C). This preliminary study does not answer whether the differences in collagen denaturation found in peritoneal tissue from different groups of patients resulted from a different inherent state of the tissue, or from surgical procedures. However, the results suggest that DSC is an appropriate method to study subtle changes in the physicochemical condition of the peritoneum using small samples obtained during surgical procedures.

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Section: Discussionmentioning

confidence: 95%

Evaluation of peritoneal tissue by means of differential scanning calorimetry (DSC)

Torres¹,

Trębacz²,

Chróścicki³

et al. 2012

Folia Histochem Cytobiol.

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“…Both pathological appearances were caused by dysfunction of smooth muscle, which was , which is the key to programmed cell death [51]. In addition, abnormal collagen metabolism is strongly associated with hernia disease [52]. Collagen is the main protein for resisting stress because of its tensile strength and it is composed of some specific anatomical structures such as the internal inguinal ring and gubernaculums [30,53].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Genome-wide association analysis of inguinal/scrotal hernia in pigs using specific length amplified fragment (SLAF) sequencing

Zou¹,

Zuo²,

Zhu³

et al. 2017

Oncotarget

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Inguinal and scrotal hernias are the most frequent congenital disorders in pigs, and they may cause severe economic loss in the pig breeding industry. Genetic factors play a significant role in the susceptibility to hernias, but the genetic mechanisms of inguinal/scrotal hernia are poorly understood. In this study, we performed a genome-wide association study (GWAS) with specific-locus amplified fragment sequencing (SLAF-seq) on 120 (59 cases and 61 controls) full and half sib pigs to identify genetic loci underlying variations in inguinal/scrotal hernias. A total of 218,460 high-quality SNPs were generated for further statistical analysis with casecontrols and the farmCPU model. Based on these two methods, a total of 59 SNPs were significantly (P < 0.01) associated with inguinal/scrotal hernia. Finally, 14 novel candidate genes implicated in the defect were identified, and 5 genes (CPNE5, DEGS1, PLCG2, PRKCE and NUAK1) were related to cell apoptosis, which is one of the pivotal pathogenesis factors of inguinal/scrotal hernia. In addition, 4 of them were shown strong associations with the hernia were confirmed in 270 samples (P < 0.05). This finding provides new evidence that genes related to cell apoptosis may be associated with inguinal/scrotal hernias.

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“…To date there is no consensus in the scientific literature regarding the factors involved in hernia genesis [11]. Recent interesting theories on collagen tissue changes have provided insight into the associated molecular changes but do not address all the histological alterations [12][13][14]. The outcomes we highlight in this report are a part of a wider study into the histological alterations of all tissue structures close to the herniated groin in cadavers.…”

Section: Discussionmentioning

confidence: 95%

Damage to the vascular structures in inguinal hernia specimens

Amato

Romano

Salamone

et al. 2011

Hernia

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Background Few scientific reports to date describe the histological modification of structures outlining a hernia opening. This article is focused on the identification of the pathological changes in vascular structures in tissues excised from cadavers with inguinal hernia. A deeper comprehension of this topic could lead to essential improvements in the detection of hernia genesis. Materials and methods Different kinds of hernia, including indirect, direct and mixed, were identified in 30 autopsied subjects. Tissue samples were resected for histological study from abdominal wall structures close to the hernia opening. Histological examination focused on the detection of structural changes in arteries and veins. The results were compared with tissue specimens excised from equivalent sites of the inguinal area in a control group of 15 fresh cadavers without hernia. Results Significant modification of vascular structures were identified in the tissue specimens examined. The veins demonstrated parietal fibrosis, perivascular edema and vascular dilation due to congestion and stasis. The arterial structures detected showed thickening of the media due to medial hyperplasia, ranging from luminal subocclusion to a manifest artery occlusion. These findings are present independent of hernia type in cadavers with inguinal hernia. These pathological changes were lacking in the control group of cadavers without hernia. Conclusions The notable changes in vascular structures described in the report could be the result of a steady compressive effect exerted by the abdominal viscera in the inguinal area. These pathological changes could represent one of the factors involved in the weakening of the inguinal region leading to hernia protrusion.

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Are collagens the culprits in the development of incisional and inguinal hernia disease?

Cited by 80 publications

References 26 publications

Evaluation of peritoneal tissue by means of differential scanning calorimetry (DSC)

Evaluation of peritoneal tissue by means of differential scanning calorimetry (DSC)

WITHDRAWN: Genome-wide association analysis of inguinal/scrotal hernia in pigs using specific length amplified fragment (SLAF) sequencing

Damage to the vascular structures in inguinal hernia specimens

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