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Cited by 77 publications
(42 citation statements)
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“…Arachidonic acid caused irreversible aggregation of human platelets at 0.7-1.0 mM and that ofrabbit platelets at 0.3-0.5 mM. As already found by other investigators (Johnson et al, 1979;Burke et al, 1983), dog platelets were not aggregated by arachidonic acid alone up to I mM, but, when treated with adrenaline, they showed irreversible aggregation around 0.5 mM arachidonic acid. We, therefore, examined the inhibitory effect of ONO-1120 on irreversible aggregation caused by minimal concentrations of arachidonic acid, e.g., 0.8, 0.4 and 0.5 mM for human, rabbit and adrenaline-treated dog platelets, respectively.…”
Section: Methodssupporting
confidence: 64%
See 1 more Smart Citation
“…Arachidonic acid caused irreversible aggregation of human platelets at 0.7-1.0 mM and that ofrabbit platelets at 0.3-0.5 mM. As already found by other investigators (Johnson et al, 1979;Burke et al, 1983), dog platelets were not aggregated by arachidonic acid alone up to I mM, but, when treated with adrenaline, they showed irreversible aggregation around 0.5 mM arachidonic acid. We, therefore, examined the inhibitory effect of ONO-1120 on irreversible aggregation caused by minimal concentrations of arachidonic acid, e.g., 0.8, 0.4 and 0.5 mM for human, rabbit and adrenaline-treated dog platelets, respectively.…”
Section: Methodssupporting
confidence: 64%
“…In contrast to these findings with rabbit platelets, we found significant binding of the ligand to dog platelets. Dog platelets are also ofinterest in terms ofthromboxane binding sites, since the platelets ofthis species respond to a thromboxane agonist and arachidonic acid only after adrenaline treatment (Johnson et al, 1979). Although this effect of adrenaline has recently been presumed to be due to suppression of .gdenylate cyclase via a-adrenoceptors (Johnson et al, 1980), there is a possibility that it evokes mobilization of thromboxane receptors on the platelet surface, as demonstrated for fibrinogen receptors (Plow & Marguerie, 1980 …”
Section: Lamentioning
confidence: 99%
“…Canine platelets exhibit complex responses to AA and its metabolites with marked inter-and intra-breed differences in platelet sensitivity to TXA 2 . There is little correlation between the ability of individual dogs to produce thromboxane and their aggregation response to AA, suggesting that inter-dog variability is due to the mechanism that mediates aggregation and secretion in response to TXA 2 (Johnson et al 1979;McGoff et al 1989). These variations are particularly apparent in the turbidometric aggregation model (Born 1962) using canine PRP (Chignard & Varagaftig 1976).…”
Section: Discussionmentioning
confidence: 97%
“…Platelet aggregation with 1 ,ul epinephrine (0.5 ,gM) and 14 g1 arachidonic acid (0.5 ,uM) per 250 gl platelet-rich plasma was performed as described elsewhere. 16 Template bleeding times were performed on the shaved left foreleg using a spring-loaded blade device (Surgicutt International Technidyne, Edison, New Jersey). Incisions were made parallel to the antecubital crease.…”
Section: Hematologic Assaysmentioning
confidence: 99%