Aqueous systems based on organophosphorous compounds in low concentrations: Interconnection of self-organization and biological properties

Рыжкина, И. С.; Муртазина, Л. И.; Shevelev, M. D.; Akhmetzyanova, L R; Галкина, И. В.; Кузнецова, Т. В.; Knyazev, I. V.; Петров, А. М.; Коновалов, А. И.

doi:10.1080/10426507.2018.1540485

Cited by 9 publications

(18 citation statements)

References 9 publications

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“…In the case of high dilutions (less than 1·10 −12 M), the actual concentration of the substance is rather difficult to confirm by experimental methods. Therefore, in our previous papers ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ), as well as in the present work, when discussing high dilutions corresponding to calculated concentrations from 1·10 −13 M to 1·10 −20 M, we use this very term implying the theoretically possible concentration of the substance at the corresponding dilution step.…”

Section: Methodsmentioning

confidence: 96%

“…Currently, a new physicochemical approach is being developed that explains and predicts the presence of bioeffects in water systems with low calculated concentrations 1 of substances and nonmonotonically dependent bioeffects on concentration ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Nanoassociates are formed as the solution is being diluted only in the presence of EMF, and characterized by dimensions of hundreds of nm, a negatively charged interface, and high susceptibility to such factors as the chemical and spatial structure of solute molecules, the properties of EMF, etc. ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…As dilution proceeds, a coherent change in the extreme values of the parameters of nanoassociates, physicochemical properties, and bioeffects of the systems are observed at practically the same critical concentrations. This made it possible to propose a hypothesis and experimentally prove that the nonmonotonic nature of the bioeffect, a change in its direction, the presence of “zones of silence” are primarily due to the transformation of the dispersed phase in the course of the systems’ dilution, rather than the decrease of the solute’s concentration ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ). Moreover, it follows that it is possible to predict the emergence of similar concentration dependences of bioeffects using nonmonotonous concentration dependences of nanoassociates' parameters and physicochemical properties of systems in the interval of low calculated concentrations ( Konovalov and Ryzhkina, 2014 ; Ryzhkina et al, 2018a ; Ryzhkina et al, 2018b ; Ryzhkina et al, 2019 ; Ryzhkina et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Diluted Aqueous Dispersed Systems of 4-Aminopyridine: The Relationship of Self-Organization, Physicochemical Properties, and Influence on the Electrical Characteristics of Neurons

et al. 2021

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A variety of physicochemical methods were used to examine the self-organization, physicochemical, UV absorption, and fluorescent properties of diluted aqueous solutions (calculated concentrations from 1·10−20 to 1·10−2 M) of the membrane voltage-dependent potassium channels blocker 4-aminopyridine (4-AP). Using the dynamic light scattering method, it was shown that 4-AP solutions at concentrations in the range of 1·10−20–1·10−6 M are dispersed systems in which domains and nanoassociates of hundreds of nm in size are formed upon dilution. An interrelation between the non-monotonic concentration dependencies of the size of the dispersed phase, the fluorescence intensity (λex 225 nm, λem 340 nm), specific electrical conductivity, and pH has been established. This allows us to predict the bioeffects of the 4-AP systems at low concentrations. The impact of these diluted aqueous systems on the electrical characteristics of identified neurons of Helix lucorum snails was studied. Incubation of neurons in the 4-AP systems for which the formation of domains and nanoassociates had been established lead to a nonmonotonic decrease of the resting potential by 7–13%. An analysis of the obtained results and published data allows for a conclusion that a consistent change in the nature and parameters of the dispersed phase, as well as the pH of the medium, apparently determines the nonmonotonic nature of the effect of the 4-AP systems in a 1·10−20–1·10−6 M concentration range on the resting membrane potential of neurons. It was found that the pre-incubation of neurons in the 4-AP system with a concentration of 1·10−12 M led to a 17.0% synergistic decrease in the membrane potential after a subsequent treatment with 1·10−2 M 4-AP solution. This finding demonstrates a significant modifying effect of self-organized dispersed systems of 4-AP in low concentrations on the neurons’ sensitivity to 4-AP.

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Section: Methodsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diluted Aqueous Dispersed Systems of 4-Aminopyridine: The Relationship of Self-Organization, Physicochemical Properties, and Influence on the Electrical Characteristics of Neurons

et al. 2021

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“…The activities of salts depend on physicochemical properties. Interesting dependences of the aggregation properties of phosphonium amphiphilic compounds on biological activities of unicellular organisms were observed by Ryzhkina et al (2019). They investigated the influence of tributylhexadecylphosphonium bromide and hexadecyltriphenylphosphonium bromide on the biological activity of infusoria (Parametium caudatum) and one single-celled algae (Chlorella vulgaris).…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Surface Activity, and Biological Activities of Phosphonium and Metronidazole Salts

Lukáč

Pisárčik

Garajová

et al. 2020

J Surfact & Detergents

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A series of phosphonium amphiphilic compounds was synthesized. Cationic parts of molecules contain triphenylphosphonium moieties. Lipophilic parts of compounds are represented by straight alkyl chain or the alkyl chains which are ornamented by benzyl or metronidazole. The physicochemical properties of phosphonium amphiphilic compounds were investigated by the measurements of surface tension and conductivity. The critical micelle concentration (cmc), the surface tension value at the cmc (γ cmc), the surface area at the surface saturation per head group (A cmc) were determined. The lowest cmc value was determined for phosphonium salts with straight dodecyl alkyl chain. Its value was 1.5 × 10 −3 mol dm −3. Surface tension at the cmc decreases with the addition of bulky moieties (benzyl, radical from metronidazol) at the end of alkyl chains. Biological activities of compounds were studied on human erythrocytes and strains of Acanthamoeba lugdunensis and Acanthamoeba quina. Dodecyltriphenylphosphonium bromide showed the highest activity against Acanthamoeba. To the best of our knowledge, it is the first compound of the group of phosphonium amphiphiles, which exhibited high activity against Acanthamoeba. The determined structure-activity relationship indicated nonspecific trophocidal and hemolytic activity that depends on physicochemical properties of the studied compounds.

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Interrelation of physicochemical, spectral, and biological properties of self-organized multi-component aqueous systems based on N-(phosphonomethyl)glycine in the low concentration range

et al. 2021

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Aqueous systems based on organophosphorous compounds in low concentrations: Interconnection of self-organization and biological properties

Cited by 9 publications

References 9 publications

Diluted Aqueous Dispersed Systems of 4-Aminopyridine: The Relationship of Self-Organization, Physicochemical Properties, and Influence on the Electrical Characteristics of Neurons

Diluted Aqueous Dispersed Systems of 4-Aminopyridine: The Relationship of Self-Organization, Physicochemical Properties, and Influence on the Electrical Characteristics of Neurons

Synthesis, Surface Activity, and Biological Activities of Phosphonium and Metronidazole Salts

Interrelation of physicochemical, spectral, and biological properties of self-organized multi-component aqueous systems based on N-(phosphonomethyl)glycine in the low concentration range

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