Aqueous photolysis of tetracycline and toxicity of photolytic products to luminescent bacteria

Jiao, Shaojun; Zheng, Shourong; Yin, Daqiang; Wang, Lianhong; Chen, Liangyan

doi:10.1016/j.chemosphere.2008.05.042

Cited by 387 publications

(170 citation statements)

References 48 publications

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“…Other pharmaceuticals such as sulfathia-zole, trimethoprim and enrofloxacin also showed similar effects on those two cladocerans in a dose-dependent manner. Luminescence inhibition on V. fischeri occurred after irradiation of tetracycline, proving that photolytic products become more toxic than the par-ent compound [137]. Antibiotics belonging to different classes have been found in different aquatic environments (Table 3).…”

Section: S Capricornutummentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,285

533

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Pharmaceuticals are biologically active and persistent substances which have been recognized as a con-tinuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless, they indicate the negative impact that these chemical contaminants may have on living organisms, ecosystems and ultimately, public health. This article reviews the different contamination sources as well as fate and both acute and chronic effects on nontarget organisms. An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented.Keywords: Pharmaceuticals, Sources, Environmental fate, Ecotoxicological effects

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Section: S Capricornutummentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,285

533

View full text Add to dashboard Cite

show abstract

“…This result provides a positive evidence for the increasing toxicity in photolysis or chlorination processes of antibiotics (Jiao et al, 2008;Li et al, 2011). Consequently, the toxicity elevation after disinfection process of pharmaceuticals should be of concerns as well.…”

Section: Estimation Of Genotoxicity For Transformation Products From Cipmentioning

confidence: 85%

Genotoxicity of quinolones: Substituents contribution and transformation products QSAR evaluation using 2D and 3D models

Wei

Zhao

et al. 2014

Chemosphere

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h i g h l i g h t sGenotoxicity of 21 quinolones was determined and analyzed with QSAR method. Big size and/or positive charge at 1-position substituent increase genotoxicity. Small size and/or negative charge at 8-position substituent increase genotoxicity. Negative charge at 7-position substituent increase genotoxicity. QSAR model showed that most metabolites had higher genotoxicity than precursor. a r t i c l e i n f o t r a c tThe genotoxicity of 21 quinolones antibiotics was determined using SOS/umu assay. Some quinolones exhibited high genotoxicity, and the chemical substituent on quinolone ring significantly affected genotoxicity. To establish the relationship between genotoxicity and substituent, a 2D-QSAR model based on quantum chemical parameters was developed. Calculation suggested that both steric and electrostatic properties were correlated well with genotoxicity. Furthermore, the specific effect on three key active sites (1-, 7-and 8-positions) of quinolone ring was investigated using a 3D-QSAR (comparative molecular field analysis, CoMFA) method. From our modeling, the genotoxicity increased when substituents had: (1) big volume and/or positive charge at 1-position; (2) negative charge at 7-position; and (3) small volume and/or negative charge at 8-position. The developed QSAR models were applicable to estimate genotoxicity of quinolones antibiotics and their transformation products. It is noted that some of the transformation products exhibited higher genotoxicity comparing to their precursor (e.g., ciprofloxacin). This study provided an alternative way to understand the molecule genotoxicity of quinolones derivatives, as well as to evaluate their potential environmental risks.

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“…However, all the residues obtained through the 3 different treatments retained their bactericidal activity. Jiao et al (2008) studied the photocatalytic degradation of tetracycline and the toxicity of its degradation products which had molar mass (m/z) equal to 398 and 413. The naphthol of the tetracycline ring remained intact during photolysis and toxicity of the compounds of photolysis using V. fischeri showed that toxicity increased with irradiation.…”

Section: Treatment and Degradation Pro-ductsmentioning

confidence: 99%

Tetracycline: production, waste treatment and environmental impact assessment

Borghi

Palma

2014

Braz. J. Pharm. Sci.

141

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The frequent occurrence of pharmaceuticals in the aquatic environment requires an assessment of their environmental impact and their negative effects in humans. Among the drugs with high harmful potential to the environment are the antibiotics that reach the environment not only, as may be expected, through the effluents from chemical and pharmaceutical industries, but mainly through the sewage and livestock; because around 25 to 75% of the ingested drugs are excreted in unchanged form after the passage through the Gastro-Intestinal Tract. Tetracycline has high world consumption, representing a human consumption of about 23 kg/day in Brazil in 2007. At the moment, researches are being made to develop new tetracycline that incorporate heavy metals (Hg, Cd, Re, Pt, Pd) to their structures in order to increase their bactericidal effect. The conventional wastewater treatment plants are not able to degrade complex organic molecules to reduce their toxicity and improve their biodegradability. For this reason new technologies, i.e., the advanced oxidation processes, are being developed to handle this demand. The objectives of this study are to review the literature on the processes of obtaining tetracycline, presenting its waste treatment methods and evaluation of their environmental impact.Uniterms: Tetracyclines/production. Tetracyclines/waste/tratament. Tetracyclines/waste/environmental impact. Environmental contamination. Domestic sewage/treatment. Industrial wastewater/treatment. Advanced oxidation processes/wastewater treatment.A ocorrência frequente de fármacos no meio aquático exige a avaliação do seu impacto ambiental e seus efeitos negativos em seres humanos. Dentre os fármacos com maior potencial de impacto ambiental estão os antibióticos, que chegam ao meio ambiente através dos efluentes de indústrias químico-farmacêuticas e, principalmente, através de esgotos domésticos e criação de animais, visto que 25% a 75% dos fármacos são excretados em forma inalterada após passagem pelo Trato Gastrointestinal. Parcela significativa do consumo mundial dos antibióticos corresponde à classe das tetraciclinas, representando consumo humano de 23 kg/dia no Brasil, em 2007. Atualmente, há pesquisas de novas tetraciclinas que incorporam metais pesados (Hg, Cd, Re, Pt, Pd) às suas estruturas com o intuito de aumentar suas atividades bactericidas. As estações de tratamento de águas residuais convencionais não são capazes de degradar moléculas orgânicas complexas, diminuir a sua toxicidade e melhorar a sua biodegradabilidade. Por esta razão, as novas tecnologias, como, por exemplo, os processos oxidativos avançados, estão sendo desenvolvidos para lidar com esta demanda. Os objetivos deste trabalho são fazer uma revisão da literatura sobre os processos de obtenção de tetraciclinas, apresentar métodos de tratamento de seus resíduos e avaliar o seu impacto ambiental.

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Aqueous photolysis of tetracycline and toxicity of photolytic products to luminescent bacteria

Cited by 387 publications

References 48 publications

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Genotoxicity of quinolones: Substituents contribution and transformation products QSAR evaluation using 2D and 3D models

Tetracycline: production, waste treatment and environmental impact assessment

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