Aqueous Humor Dynamics in Exfoliation Syndrome

Aqueous Humor Dynamics in Pigment Dispersion Syndrome

“…This is in contrast to exfoliation syndrome, in which uveoscleral outflow was significantly lower than normal. 35 Our data did show a higher mean uveoscleral outflow in PDS with normal IOP compared with age-matched controls and patients with PDS and elevated IOP, even though the difference did not reach statistical significance (P=.05), likely because of the small sample size of the study groups. This could indicate that the patients with PDS and higher available uveoscleral outflow rates can maintain lower IOPs compared with those with lower uveoscleral outflow rates.…”

“…The baseline IOPs in the PDS-OHT (23.7 [3.4] The results are summarized in the Table. COMMENT As with a previous study, 9 we found that the main factor accounting for the increased IOP in PDS is the increased resistance to flow through the trabecular meshwork (decreased outflow facility). Similar effects on outflow facility have been reported for other diseases associated with elevated IOP, including primary openangle glaucoma, 11,14,31,32 OHT, 12,31,33 and exfoliation syndrome without 34,35 or with 36 glaucoma. Our patients with PDS and normal IOP (Յ20 mm Hg) had outflow facility values that were not significantly different from those of healthy age-matched controls, although the mean value fell between the values for the healthy control group and the PDS-OHT group.…”

Aqueous Humor Dynamics in Pigment Dispersion Syndrome

“…This is in contrast to exfoliation syndrome, in which uveoscleral outflow was significantly lower than normal. 35 Our data did show a higher mean uveoscleral outflow in PDS with normal IOP compared with age-matched controls and patients with PDS and elevated IOP, even though the difference did not reach statistical significance (P=.05), likely because of the small sample size of the study groups. This could indicate that the patients with PDS and higher available uveoscleral outflow rates can maintain lower IOPs compared with those with lower uveoscleral outflow rates.…”

“…The baseline IOPs in the PDS-OHT (23.7 [3.4] The results are summarized in the Table. COMMENT As with a previous study, 9 we found that the main factor accounting for the increased IOP in PDS is the increased resistance to flow through the trabecular meshwork (decreased outflow facility). Similar effects on outflow facility have been reported for other diseases associated with elevated IOP, including primary openangle glaucoma, 11,14,31,32 OHT, 12,31,33 and exfoliation syndrome without 34,35 or with 36 glaucoma. Our patients with PDS and normal IOP (Յ20 mm Hg) had outflow facility values that were not significantly different from those of healthy age-matched controls, although the mean value fell between the values for the healthy control group and the PDS-OHT group.…”

Outflow Facility in Mice with a Targeted Type I Collagen Mutation

“…Moreover, the magnitude of outflow facility reduction was inversely correlated with the magnitude of IOP elevation. The decrease in facility observed in these transgenic mice with elevated IOP was consistent with the findings of reduced outflow facility in patients with ocular hypertension 15–17…”

Preservative-free tafluprost in the treatment of naive patients with glaucoma and ocular hypertension

“……”

Aqueous Humor Dynamics in Pigment Dispersion Syndrome

“…This is in contrast to exfoliation syndrome, in which uveoscleral outflow was significantly lower than normal. 35 Our data did show a higher mean uveoscleral outflow in PDS with normal IOP compared with age-matched controls and patients with PDS and elevated IOP, even though the difference did not reach statistical significance (P=.05), likely because of the small sample size of the study groups. This could indicate that the patients with PDS and higher available uveoscleral outflow rates can maintain lower IOPs compared with those with lower uveoscleral outflow rates.…”

“…The baseline IOPs in the PDS-OHT (23.7 [3.4] The results are summarized in the Table. COMMENT As with a previous study, 9 we found that the main factor accounting for the increased IOP in PDS is the increased resistance to flow through the trabecular meshwork (decreased outflow facility). Similar effects on outflow facility have been reported for other diseases associated with elevated IOP, including primary openangle glaucoma, 11,14,31,32 OHT, 12,31,33 and exfoliation syndrome without 34,35 or with 36 glaucoma. Our patients with PDS and normal IOP (Յ20 mm Hg) had outflow facility values that were not significantly different from those of healthy age-matched controls, although the mean value fell between the values for the healthy control group and the PDS-OHT group.…”

Outflow Facility in Mice with a Targeted Type I Collagen Mutation

“…Moreover, the magnitude of outflow facility reduction was inversely correlated with the magnitude of IOP elevation. The decrease in facility observed in these transgenic mice with elevated IOP was consistent with the findings of reduced outflow facility in patients with ocular hypertension 15–17…”

Preservative-free tafluprost in the treatment of naive patients with glaucoma and ocular hypertension

“……”

Aqueous Humor Dynamics in Pigment Dispersion Syndrome

“…This is in contrast to exfoliation syndrome, in which uveoscleral outflow was significantly lower than normal. 35 Our data did show a higher mean uveoscleral outflow in PDS with normal IOP compared with age-matched controls and patients with PDS and elevated IOP, even though the difference did not reach statistical significance (P=.05), likely because of the small sample size of the study groups. This could indicate that the patients with PDS and higher available uveoscleral outflow rates can maintain lower IOPs compared with those with lower uveoscleral outflow rates.…”

“…The baseline IOPs in the PDS-OHT (23.7 [3.4] The results are summarized in the Table. COMMENT As with a previous study, 9 we found that the main factor accounting for the increased IOP in PDS is the increased resistance to flow through the trabecular meshwork (decreased outflow facility). Similar effects on outflow facility have been reported for other diseases associated with elevated IOP, including primary openangle glaucoma, 11,14,31,32 OHT, 12,31,33 and exfoliation syndrome without 34,35 or with 36 glaucoma. Our patients with PDS and normal IOP (Յ20 mm Hg) had outflow facility values that were not significantly different from those of healthy age-matched controls, although the mean value fell between the values for the healthy control group and the PDS-OHT group.…”

Outflow Facility in Mice with a Targeted Type I Collagen Mutation

“…Moreover, the magnitude of outflow facility reduction was inversely correlated with the magnitude of IOP elevation. The decrease in facility observed in these transgenic mice with elevated IOP was consistent with the findings of reduced outflow facility in patients with ocular hypertension 15–17…”

Preservative-free tafluprost in the treatment of naive patients with glaucoma and ocular hypertension

“……”