Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats

Rosales-Reyes, Tábata; Garza, Mireya de la; Arias-Castro, Carlos; Rodríguez-Mendiola, M. A.; Fattel-Fazenda, Samia; Arce-Popoca, Evelia; Hernández-García, Sergio; Villa‐Treviño, Saúl

doi:10.1016/j.jep.2007.10.022

Cited by 29 publications

(23 citation statements)

References 16 publications

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“…This has also been emphasized recently by Rosales-Reyes et al . [54]. Studies reporting the antidiarrhoeal activity of the aqueous extracts of P. guajava leaves both in animal models as well as in clinical trials [17] further strengthen the use of decoction in the present study.…”

Section: Discussionsupporting

confidence: 66%

Newer insights into the mechanism of action of Psidium guajava L. leaves in infectious diarrhoea

Birdi

Daswani

Brijesh

et al. 2010

BMC Complement Altern Med

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BackgroundPsidium guajava L., Myrtaceae, is used widely in traditional medicine for the treatment of diarrhoea, dysentery, gastroenteritis, stomachaches, and indigestion. However, the effect of the leaf extract of P. guajava on the pathogenesis of infectious diarrhoea has not been studied. The present study evaluates the effect of a hot aqueous extract (decoction) of dried leaves of P. guajava on parameters associated with pathogenicity of infectious diarrhoea. The aim was to understand its possible mechanism(s) of action in controlling infectious diarrhoea and compare it with quercetin, one of the most reported active constituents of P. guajava with antidiarrhoeal activity.MethodsThe crude decoction and quercetin were studied for their antibacterial activity and effect on virulence features of common diarrhoeal pathogens viz. colonization of epithelial cells and production and action of enterotoxins. Colonization as measured by adherence of enteropathogenic Escherichia coli (EPEC) and invasion of enteroinvasive E. coli (EIEC) and Shigella flexneri was assessed using HEp-2 cell line. The production of E. coli heat labile toxin (LT) and cholera toxin (CT) and their binding to ganglioside monosialic acid (GM1) were studied by GM1-ELISA whereas the production and action of E. coli heat stable toxin (ST) was assessed by suckling mouse assay.ResultsThe decoction of P. guajava showed antibacterial activity towards S. flexneri and Vibrio cholerae. It decreased production of both LT and CT and their binding to GM1. However, it had no effect on production and action of ST. The decoction also inhibited the adherence of EPEC and invasion by both EIEC and S. flexneri to HEp-2 cells. Quercetin, on the other hand, had no antibacterial activity at the concentrations used nor did it affect any of the enterotoxins. Although it did not affect adherence of EPEC, it inhibited the invasion of both EIEC and S. flexneri to HEp-2 cells.ConclusionCollectively, the results indicate that the decoction of P. guajava leaves is an effective antidiarrhoeal agent and that the entire spectrum of its antidiarrhoeal activity is not due to quercetin alone.

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Section: Discussionsupporting

confidence: 66%

Newer insights into the mechanism of action of Psidium guajava L. leaves in infectious diarrhoea

Birdi

Daswani

Brijesh

et al. 2010

BMC Complement Altern Med

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“…Hormesis is a dose response phenomenon characterized by a low dose inhibition and high dose stimulation or vice versa, resulting in either a J-shaped or an inverted U-shaped dose response. The biochemical mechanisms by which hormesis work are not well understood (Rosales-Reyes et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive, hypoglycemic and spasmolytic effects of Brickellia veronicifolia

Palacios‐Espinosa

Déciga-Campos

Mata

2008

Journal of Ethnopharmacology

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“…A number of flavonoids, saponins, carotenoids, waxes, terpenoids, coumarinic and steroidal compounds have been previously isolated from this plant (Rosales‐Reyes et al . ; Tan et al . ).…”

Section: Discussionmentioning

confidence: 99%

Combined genetic and bioactivity‐based prioritization leads to the isolation of an endophyte‐derived antimycobacterial compound

et al. 2016

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Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats

Cited by 29 publications

References 16 publications

Newer insights into the mechanism of action of Psidium guajava L. leaves in infectious diarrhoea

Newer insights into the mechanism of action of Psidium guajava L. leaves in infectious diarrhoea

Antinociceptive, hypoglycemic and spasmolytic effects of Brickellia veronicifolia

Combined genetic and bioactivity‐based prioritization leads to the isolation of an endophyte‐derived antimycobacterial compound

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