Aquaporin 3 Expression in Human Fetal Membranes and its Up-regulation by Cyclic Adenosine Monophosphate in Amnion Epithelial Cell Culture

Wang, Shengbiao; Amidi, Fataneh; Beall, Marie H.; Gui, Lizhen; Ross, Michael G.

doi:10.1016/j.jsgi.2006.02.002

Cited by 42 publications

(38 citation statements)

References 23 publications

(4 reference statements)

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“…Saadoun et al (2005) demonstrated that AQP1 promotes cell migration in epithelial cells from wild-type mice as compared to AQP1-null mice. We also demonstrated that increasing concentrations of cAMP have a stimulatory effect on AQP1 which extends our previous studies showing that cAMP stimulated both AQP8 in human amnion-derived WISH cells (Wang et al, 2003) as well as AQP3 in primary human amnion cell cultures (Wang et al, 2006). Together, these data provide strong evidence that AVP at a physiological concentration may play a role in water balance in placental trophoblasts cells by acting through a cAMP signaling pathway to increase AQP1 expression.…”

Section: Discussionsupporting

confidence: 87%

“…Furthermore incubation with 8-bromo-cAMP or direct 8-bromo-cAMP injection into oocytes expressing AQP1 cRNA significantly increased membrane permeability to water, suggesting that stimulation of AQP1 activity by AVP involves a cAMP-dependent mechanism (Patil et al, 1997). Previous work in our laboratory demonstrated that AQP3 is stimulated by cAMP agonists in human amnion cultures (Wang et al, 2006) suggesting a role for this molecule in amniotic fluid homeostasis. Since the placenta may have a role in amniotic-fetal water homeostasis through AQP regulation, the modulation of these AQPs in the placenta may be influenced by the level of AVP or cAMP in this organ.…”

Section: Introductionmentioning

confidence: 80%

“…To date 13 aquaporins (AQPs) have been identified in mammals , and they play a critical role in controlling water flow particularly in specialized fluid-conducting organs such as kidney, lachrymal glands, lung and fetal membranes (Wintour, 1998;Liu et al, 2000, Ross andBrace, 2001;Magann et al, 2003). AQP gene expression has been seen in both placenta and fetal membranes across a diversity of species (Hasegawa et al, 1994;Ma et al, 1997;Johnston et al, 2000;Damiano et al, 2001;Wang et al, 2001;Mann et al, 2002;Wang et al, 2004;Liu et al, 2004;Wang et al, 2006); however their role in placental-amniotic-fetal water homeostasis has not been fully defined.…”

Section: Introductionmentioning

confidence: 99%

“…Many hormones controlling water homeostasis including AVP exert their effects via cAMP (3′, 5′-cyclic adenosine monophosphate) by altering AQPs gene expression (DiGiovanni et al, 1994;Itoh et al, 2003;Wang et al, 2006). It was shown that the application of AVP to Xenopus oocytes injected with AQP1 cRNA increased the membrane permeability to water (Patil et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells

et al. 2008

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells

et al. 2008

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“…Transcellular movement of water and solutes across the membranes during pregnancy, the intramembranous pathway, is a major pathway of fluid transport, in which aquaporin channels play a primary role [10]. Of the 13 currently recognized aquaporin water channels, aquaporins 1, 3, 8, and 9 have all been identified within the human placental unit [36,[57][58][59]. Wang et al [36] performed a series of in vitro studies demonstrating aquaporin 9 mRNA expression in human amnion, chorion, and placenta.…”

Section: Normal Pregnancy and Aquaporinmentioning

confidence: 99%

Fetal membranes as an interface between inflammation and metabolism: Increased Aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis

Mittal¹,

Romero²,

Mazaki‐Tovi³

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective. Aquaporin 9 (AQP9) is a water channel protein characterized by its high permeability to nutrients such as lactate and glycerol, as well as urea and other small solutes. These unique properties of AQP9 suggest that this molecule may play a role in the modulation of nutrient flux through the fetal membranes in conditions associated with increased metabolic demand, such as spontaneous labor and inflammation. The objective of this study was to determine the expression of AQP9 in the chorioamniotic membranes from women with and without term labor, as well as those with preterm prelabor rupture of membranes (PPROM) with and without histologic chorioamnionitis. Study design. A cross-sectional study was performed which included patients in the following groups: (1) term not in labor (TNL; n ¼ 14); (2) term, spontaneous labor (n ¼ 14); and (3) PPROM with (n ¼ 20) and without (n ¼ 17) histologic chorioamnionitis. AQP9 mRNA expression in fetal membranes was quantified using quantitative real-time reverse transcription-polymerase chain reaction and analyzed with a linear model including gestational age as a covariate. Results. (1) AQP9 mRNA expression was identified in all chorioamniotic membrane specimens; (2) AQP9 expression in fetal membranes was significantly higher in spontaneous term labor when compared with TNL (fold change 3.6; p ¼ 0.01); and (3) Among patients with PPROM, the presence of histologic chorioamnionitis was associated with a higher expression of AQP9 in the chorioamniotic membranes compared with those from women without histologic chorioamnionitis (fold change 8.7; p 5 0.001). Conclusion. Aquaporin 9 mRNA expression is higher in the fetal membranes from patients with spontaneous term labor and those with PPROM and histologic chorioamnionitis. These findings are novel, and suggest a role for aquaporin 9 in membrane-mediated transfer of nutrients to support the increased metabolic demands associated with the host immune response of the terminal pathway of parturition and histologic chorioamnionitis.

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Salinity effects on expression and localization of aquaporin 3 in gills of the euryhaline milkfish (Chanos chanos)

Lee

2023

J Exp Zool Pt A

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Milkfish (Chanos chanos) are important euryhaline fish in Southeast Asian countries that can tolerate a wide range of salinity changes. Previous studies have revealed that milkfish have strong ion regulation and survival abilities under osmotic stress. In addition to ion regulation, water homeostasis in euryhaline teleosts is important during environmental salinity shifts. Aquaporins (AQP) are vital water channels in fish, and different AQPs can transport water influx or outflux from the body. AQP3 is one of the AQP channels, and the function of AQP3 in the gills of euryhaline milkfish is still unknown. The aim of this study was to investigate the expression and localization of AQP3 in the gills of euryhaline milkfish to contribute to our understanding of the physiological role and localization of AQP3 in fish. The AQP3 sequence was found in the milkfish next‐generation sequencing (NGS) database and is mainly distributed in the gills of freshwater (FW)‐acclimated milkfish. Under hypoosmotic and hyperosmotic stress, the osmolality of milkfish immediately shifted, similar to the aqp3 gene expression. Moreover, the abundance of AQP3 protein significantly decreased 3 h after transferring milkfish from FW to seawater (SW). However, there was no change within 7 days when the milkfish experienced hypoosmotic stress. Moreover, double immunofluorescence staining of milkfish gills showed that AQP3 colocalized with Na+/K+ ATPase at the basolateral membrane of ionocytes. These results combined indicate that milkfish have a strong osmoregulation ability under acute osmotic stress because of the quick shift in the gene and protein expression of AQP3 in their gills.

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Aquaporin 3 Expression in Human Fetal Membranes and its Up-regulation by Cyclic Adenosine Monophosphate in Amnion Epithelial Cell Culture

Cited by 42 publications

References 23 publications

AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells

AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells

Fetal membranes as an interface between inflammation and metabolism: Increased Aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis

Salinity effects on expression and localization of aquaporin 3 in gills of the euryhaline milkfish (Chanos chanos)

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