2018
DOI: 10.1159/000494788
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Abstract: Background/Aims: Previous studies have shown that oxidative damage is a main contributor to disc nucleus pulposus (NP) cell apoptosis. Aquaporin-3 (AQP-3) facilitates reactive oxygen species (ROS) scavenging and thus alleviates oxidative injury in other cells. This study aims to investigate the role and mechanism of AQP-3 in regulating NP cell apoptosis under oxidative damage. Methods: Rat NP cells were treated with H2O2 for 48 hours, while control NP cells were free of H2O Show more

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Cited by 27 publications
(22 citation statements)
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“…29 They were caused by the increased levels of oxidative stress or inflammatory cytokines in the degenerated IVD tissues. 30,31 The current study demonstrated whether the pyroptosis involved in the IVDD formation. We first established an IVDD model by IVD puncture and found that NLRP3-mediated NP cell pyroptosis was activated in the progression of IVDD, with the initiation of the NLRP3 inflammasome, up-regulation of caspase-1 and cleaved GSDMD, as well as increased secretion of downstream cytokines IL-18 and IL-1β.…”
Section: Discussionmentioning
confidence: 51%
“…29 They were caused by the increased levels of oxidative stress or inflammatory cytokines in the degenerated IVD tissues. 30,31 The current study demonstrated whether the pyroptosis involved in the IVDD formation. We first established an IVDD model by IVD puncture and found that NLRP3-mediated NP cell pyroptosis was activated in the progression of IVDD, with the initiation of the NLRP3 inflammasome, up-regulation of caspase-1 and cleaved GSDMD, as well as increased secretion of downstream cytokines IL-18 and IL-1β.…”
Section: Discussionmentioning
confidence: 51%
“…Accumulative evidence indicates that overproduction of reactive oxygen species (ROS), which results in oxidative stress, plays a critical role in the damage of chondrocytes upon exposure to these etiological factors [1]. Excessive ROS reinforces inflammation and degradation of the extracellular matrix, changes cartilaginous phenotype, accelerates senescence of disc cells, and even triggers programmed cell death [2,3]. These pathological reactions are dependent on ROS acting as crucial intermediary factors in the signaling network and on the strong oxidation characteristics.…”
Section: Introductionmentioning
confidence: 99%
“…H 2 O 2 , as an oxidative stress inducer, may activate ERK and p38 proteins in cells, which may be closely related to MAPK signalling pathway [18,19]. Xu et al [20] found that after treatment with H 2 O 2 , ERK and p38 proteins was activated. In our experiments, when treatment with H 2 O 2 , protein related to MAPK significantly increased than control group.…”
Section: Discussionmentioning
confidence: 99%