Aptamer-modified DNA tetrahedra-gated metal–organic framework nanoparticle carriers for enhanced chemotherapy or photodynamic therapy

Zhang, Pu; Fischer, Amit; Ouyang, Yu; Wang, Jianbang; Sohn, Yang Sung; Nechushtai, Rachel; Pikarsky, Eli; Fan, Chunhai; Willner, Itamar

doi:10.1039/d1sc04229g

Cited by 42 publications

(27 citation statements)

References 77 publications

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“…In recent years, much effort has been devoted to mitigating DOX-related cardiotoxicity. PDT has favorable biocompatibility and has been widely used 34 . Using precise laser source positioning, PDT can selectively aggregate photosensitizers.…”

Section: Discussionmentioning

confidence: 99%

A photochemical-responsive nanoparticle boosts doxorubicin uptake to suppress breast cancer cell proliferation by apoptosis

Zhang

Han

et al. 2022

Sci Rep

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In the course of chemotherapy for breast cancer, doxorubicin (DOX) is one of the most commonly prescribed agents. However, it has been recognized as clinically circumscribed on account of its poor selectivity and toxic reactions to normal tissues. Fortunately, the distinct merit of photochemical-responsive nanoparticle delivery systems to enhance cellular drugs uptake through localized concentration, adequate selective and minimizing systemic toxicity has aroused substantial interest recently. In this study, we synthesized photochemical-responsive nanoparticle by incorporating DOX, curcumin (CUR), and perfluorooctyl bromide (PFOB) into poly(lactic-co-glycolic acid) (PLGA) via double emulsification (DOX–CUR–PFOB–PLGA). The synthesized composite nanoparticles, which featured good ultrasound imaging, engendered photochemical activation for drug release when given laser irradiation. Cumulative release rates for DOX were 76.34%, and for CUR were 83.64%, respectively. Also, MCF-7 cells displayed significant intracellular DOX uptake and reactive oxygen species (ROS) levels, degraded cytoskeleton, and decreased cell growth and migration capacity. At the molecular level, cellular pAKT levels decreased, which resulted in downregulated HIF-1α and BAX/BCl-2 levels, leading to Caspase-3 activation and thus induction of apoptosis. Therefore, the photochemical-responsive nanoparticles possess the potential to elicit apoptosis in MCF-7 cells via enhanced DOX uptake.

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Section: Discussionmentioning

confidence: 99%

A photochemical-responsive nanoparticle boosts doxorubicin uptake to suppress breast cancer cell proliferation by apoptosis

Zhang

Han

et al. 2022

Sci Rep

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“…Accordingly, the high cytotoxic selectivity towards the MDA-MB-231 cells was attributed to the effective permeation of the AS1411-modified gated NMOFs into the MDA-MB-231 cancer cells followed by their efficient unlocking by the VEGF biomarkers expressed inside the cells, resulting in the release of the DOX chemotherapeutic drug. In a related study, 238 the UiO-66 NMOFs were functionalized with the nucleic acid ( 65 ), loaded with the Zn( ii )PPIX photosensitizer and locked with the ( 66 )-nucleic acid tethered DNA structure, ( 66 )-T, where the tether ( 66 ) corresponded to the anti-VEGF aptamer sequence. The DNA-tetrahedra was conjugated to the aptamer, acting as a functional unit that enhances permeability of the NMOFs into cells.…”

Section: G-quadruplex-responsive Carriers For Therapeutic Applicationsmentioning

confidence: 99%

Switchable and dynamic G-quadruplexes and their applications

2022

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“…Besides BP, red phosphorus (RP) can also generate reactive oxygen species under visible light irradiation ( Zhang P. et al, 2021 ). Among them, Z-type RP/BP nanosheets prepared by exploiting the high separation efficiency of electron-hole pairs not only have photocatalytic activity, but also ROS can be generated with higher efficiency ( Liu et al, 2019 ).…”

Section: Strategies For Nanoparticle-based Photocontrolled Deliverymentioning

confidence: 99%

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

Chen

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the three elements of PDT (light, oxygen, and photosensitizers) can improve the efficacy of PDT. However, traditional PDT is confronted some challenges of poor solubility of photosensitizers and tumor suppressive microenvironment. To overcome the related obstacles of PDT, various strategies have been investigated in terms of improving photosensitizers (PSs) delivery, penetration of excitation light sources, and hypoxic tumor microenvironment. In addition, compared with a single treatment mode, the synergistic treatment of multiple treatment modalities such as photothermal therapy, chemotherapy, and radiation therapy can improve the efficacy of PDT. This review summarizes recent advances in nanomaterials, including metal nanoparticles, liposomes, hydrogels and polymers, to enhance the efficiency of PDT against malignant tumor.

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Aptamer-modified DNA tetrahedra-gated metal–organic framework nanoparticle carriers for enhanced chemotherapy or photodynamic therapy

Cited by 42 publications

References 77 publications

A photochemical-responsive nanoparticle boosts doxorubicin uptake to suppress breast cancer cell proliferation by apoptosis

A photochemical-responsive nanoparticle boosts doxorubicin uptake to suppress breast cancer cell proliferation by apoptosis

Switchable and dynamic G-quadruplexes and their applications

Progress of Nanomaterials in Photodynamic Therapy Against Tumor

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