Direct accounting for durability rarely finds its way into multidisciplinary optimization. Though reduction of loads by some means can certainly have a beneficial influence on the fatigue performance of a structure, changes in load levels are not a direct measure of the influence of design changes on fatigue performance. In this paper, an assessment is made of an approach to the calculation of design sensitivities of a fatigue performance index namely, number of damaging cycles to failure. The approach makes use of analytical sensitivities of structural dynamic response, and a standard approach to the calculation of fatigue performance. The method is demonstrated using a simple nine degree-of-freedom structural model of an automobile in a conceptual representation of the industrial practice of road testing and road simulation. Results suggest that the estimates of changes in fatigue life are of sufficient quality for typical fatigue life evaluations, and open the door for the incorporation of a direct measure of fatigue performance in formal structural optimization.