Approaches to vascular network, blood flow, and metabolite distribution modeling in brain tissue

Kopylova, Veronika; Boronovskiy, Stanislav; Nartsissov, Yaroslav

doi:10.1007/s12551-023-01106-0

Cited by 3 publications

(1 citation statement)

References 169 publications

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“…The information obtained thanks to imaging methods allowed for the visualization of stenoses and the creation of accurate CFD simulation models. CFD simulations can be a valuable tool in a wide range of blood flows in the circulatory system [10,27,[63][64][65][66][67][68][69][70][71][72][73], providing valuable information for physicians. CFD can provide information on high shear stress [10,[63][64][65], which is one of the factors causing blood hemolysis, which negatively affects patients' health [74].…”

Section: Discussionmentioning

confidence: 99%

Prediction of Hemodynamic-Related Hemolysis in Carotid Stenosis and Aiding in Treatment Planning and Risk Stratification Using Computational Fluid Dynamics

Jędrzejczak,

Orciuch,

Wojtas

et al. 2023

Biomedicines

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Atherosclerosis affects human health in many ways, leading to disability or premature death due to ischemic heart disease, stroke, or limb ischemia. Poststenotic blood flow disruption may also play an essential role in artery wall impairment linked with hemolysis related to shear stress. The maximum shear stress in the atherosclerotic plaque area is the main parameter determining hemolysis risk. In our work, a 3D internal carotid artery model was built from CT scans performed on patients qualified for percutaneous angioplasty due to its symptomatic stenosis. The obtained stenosis geometries were used to conduct a series of computer simulations to identify critical parameters corresponding to the increase in shear stress in the arteries. Stenosis shape parameters responsible for the increase in shear stress were determined. The effect of changes in the carotid artery size, length, and degree of narrowing on the change in maximum shear stress was demonstrated. Then, a correlation for the quick initial diagnosis of atherosclerotic stenoses regarding the risk of hemolysis was developed. The developed relationship for rapid hemolysis risk assessment uses information from typical non-invasive tests for treated patients. Practical guidelines have been developed regarding which stenosis shape parameters pose a risk of hemolysis, which may be adapted in medical practice.

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Section: Discussionmentioning

confidence: 99%

Prediction of Hemodynamic-Related Hemolysis in Carotid Stenosis and Aiding in Treatment Planning and Risk Stratification Using Computational Fluid Dynamics

Jędrzejczak,

Orciuch,

Wojtas

et al. 2023

Biomedicines

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VII Congress of Russian Biophysicists—2023, Krasnodar, Russia

Anashkina,

Rubin,

Gudimchuk

et al. 2023

Biophys Rev

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

de Lima,

Tanaka,

Lamas

et al. 2024

Biomedicines

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The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the muscle mass reduction seen in sarcopenia and the decline in neuronal function characteristic of neurodegeneration. Our limited understanding of the intricate relationships within this triad hinders accurate diagnosis and effective treatment strategies. This review analyzes the interrelated mechanisms that contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, and impaired nutrient delivery. The aim is to understand the common pathways involved and to suggest comprehensive therapeutic approaches. Vascular dysfunctions hinder the circulation of blood and the transportation of nutrients, resulting in sarcopenia characterized by muscle atrophy and weakness. Vascular dysfunction and sarcopenia have a negative impact on physical function and quality of life. Neurodegenerative diseases exhibit comparable pathophysiological mechanisms that affect cognitive and motor functions. Preventive and therapeutic approaches encompass lifestyle adjustments, addressing oxidative stress, inflammation, and integrated therapies that focus on improving vascular and muscular well-being. Better understanding of these links can refine therapeutic strategies and yield better patient outcomes. This study emphasizes the complex interplay between vascular dysfunction, muscle degeneration, and cognitive decline, highlighting the necessity for multidisciplinary treatment approaches. Advances in this domain promise improved diagnostic accuracy, more effective therapeutic options, and enhanced preventive measures, all contributing to a higher quality of life for the elderly population.

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Approaches to vascular network, blood flow, and metabolite distribution modeling in brain tissue

Cited by 3 publications

References 169 publications

Prediction of Hemodynamic-Related Hemolysis in Carotid Stenosis and Aiding in Treatment Planning and Risk Stratification Using Computational Fluid Dynamics

Prediction of Hemodynamic-Related Hemolysis in Carotid Stenosis and Aiding in Treatment Planning and Risk Stratification Using Computational Fluid Dynamics

VII Congress of Russian Biophysicists—2023, Krasnodar, Russia

Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

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