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“…This study only investigated a subgroup of hypertrophic cardiomyopathy patients which comprises approximately 5-10% of all patients with this disease' 42 ', but might nevertheless contribute to judgement. Although symptomatic, many patients showed quite good exercise tolerance despite their V0 2rn ax being reduced but further analysis on these investigations will follow.…”
Section: Limitations Of the Studymentioning
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“…This study only investigated a subgroup of hypertrophic cardiomyopathy patients which comprises approximately 5-10% of all patients with this disease' 42 ', but might nevertheless contribute to judgement. Although symptomatic, many patients showed quite good exercise tolerance despite their V0 2rn ax being reduced but further analysis on these investigations will follow.…”
Section: Limitations Of the Studymentioning
“…1, 4 Cibenzoline, another antiarrhythmic drug, has also been used in some countries with reportedly good results. 5, 6 However, medical treatment fails to relieve symptoms in a considerable number of patients with LVOT obstruction 7 and surgical treatment with septal myectomy/myotomy has been the traditional gold standard treatment for such patients, with excellent results in highly experienced centers. 8 Percutaneous transluminal septal myocardial ablation (PTSMA: the injection of alcohol in a septal perforator branch perfusing the basal septum) has emerged as an efficacious alternative treatment option in the past 15 years.…”
mentioning
“…As suggested in this patient, there is a question whether the acute change in left ventricular outflow tract gradient in patients with hypertrophic obstructive cardiomyopathy can be used as a reliable indicator of a response to therapy [10]. Since the left ventricular outflow tract gradient is dependent on contractility as well as loading conditions, alterations in either of these two variables may produce a variation in the outflow tract gradient in the absence of mechanical intervention.…”
Section: Discussionmentioning
“…Caution must be exercised in applying dual-chamber pacing as a treatment for the complex disease characterized by an abnormally hypertrophied, noncompliant left ventricle. Maron [10] also noted that pacing has no defined role in diminishing the risk for sudden cardiac death nor in relieving symptoms of patients with nonobstructive hypertrophic myopathy. Until the uncertainty regarding the role of efficacy of DDD pacing is resolved, clinicians should be aware of potentially deleterious effects or a lack of clinical benefit that may occur with DDD pacing in a patient with hypertrophic obstructive cardiomyopathy.…”
Section: Discussionmentioning
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