Applications of Metallic Nanoparticles in Antimicrobial Therapy

Gómez, Hinojal Zazo; Millán, Carmen Gutiérrez; Colino, Clara I.; Lanao, José M.

doi:10.1016/b978-0-323-52733-0.00015-x

Cited by 13 publications

(9 citation statements)

References 241 publications

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“…[ 209 ] Many metallic NPs have been tested as therapeutic agents and sterilizers against a variety of viruses. Metallic NPs prevent viruses from entering host cells or affect their capacity to replicate, [ 210,211 ] with the most commonly used materials being copper, silver, and gold NPs (Cu/Ag/Au‐NPs) [ 212 ] and Ag‐NPs being the most effective. [ 211 ] These NPs have been tested against a range of viruses, including HIV, hepatitis B virus (HBV), HSV‐1/2, and influenza viruses.…”

Section: Metals Against Virusesmentioning

confidence: 99%

“…Au‐NPs are important owing to their reduced toxicity as compared to that associated with other metallic NPs. [ 212 ] Asharani et al. compared the toxicity of Ag‐NPs, Au‐NPs, and Pt‐NPs using zebrafish embryos: Ag‐NPs were the most toxic, while Au‐NPs did not have any detrimental effect on developing zebrafish embryos, i.e., Au‐NPs were nontoxic under the conditions studied.…”

Section: Metals Against Virusesmentioning

confidence: 99%

See 1 more Smart Citation

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

Rodrigues

Campo

Arns

et al. 2021

Part & Part Syst Charact

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Infectious diseases caused by viruses are a global health concern and have become prominent in light of the recent COVID‐19 pandemic. Considering the limitations of drugs and prophylactic methods used in current medicine, antiviral materials are a useful strategy in preventing the spread of viruses and enhancing treatment efficiency. Thus, this review highlights the state‐of‐the‐art antiviral materials, describes the scientific landscape of the primary antiviral materials used based on bibliometric analysis, presents their mechanisms of action, and discusses their clinical applications. The mechanisms of action underlying the broad‐spectrum antiviral properties of metals, ceramics, polymers, and composites are also discussed. Polyanions, polycations, oxides, and metal‐based materials, from bulk to nanoparticles, have good potential in antiviral applications that may help prepare the world for future viral breakouts.

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Section: Metals Against Virusesmentioning

confidence: 99%

Section: Metals Against Virusesmentioning

confidence: 99%

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

Rodrigues

Campo

Arns

et al. 2021

Part & Part Syst Charact

View full text Add to dashboard Cite

show abstract

“…Different kinds of nanoparticles have demonstrated their potential for the diagnosis, treatment and prevention of viral infections in many applications, especially those nanoparticles with viral material or systems that mimic virus characteristics. This section focuses on the diagnostic techniques developed for the identification and/or quantification of viruses themselves, and more specifically of the viruses that have been more thoroughly investigated and have more relevance [ 71 , 72 , 73 , 74 , 75 , 76 , 77 ].…”

Section: Nanoparticles For Viral Detectionmentioning

confidence: 99%

Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases

Colino

Millán

Lanao

2018

IJMS

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Advances in nanoparticle-based systems constitute a promising research area with important implications for the treatment of bacterial infections, especially against multidrug resistant strains and bacterial biofilms. Nanosystems may be useful for the diagnosis and treatment of viral and fungal infections. Commercial diagnostic tests based on nanosystems are currently available. Different methodologies based on nanoparticles (NPs) have been developed to detect specific agents or to distinguish between Gram-positive and Gram-negative microorganisms. Also, biosensors based on nanoparticles have been applied in viral detection to improve available analytical techniques. Several point-of-care (POC) assays have been proposed that can offer results faster, easier and at lower cost than conventional techniques and can even be used in remote regions for viral diagnosis. Nanoparticles functionalized with specific molecules may modulate pharmacokinetic targeting recognition and increase anti-infective efficacy. Quorum sensing is a stimuli-response chemical communication process correlated with population density that bacteria use to regulate biofilm formation. Disabling it is an emerging approach for combating its pathogenicity. Natural or synthetic inhibitors may act as antibiofilm agents and be useful for treating multi-drug resistant bacteria. Nanostructured materials that interfere with signal molecules involved in biofilm growth have been developed for the control of infections associated with biofilm-associated infections.

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“…They have an excellent and promising potential use in biomedical applications [4], including bioimaging [5], thermal therapy [6], and drug delivery [7]. They have also been studied for their antimicrobial [8][9][10] and cytotoxic activities [11][12][13], with satisfying results. There are several methods by which metal nanoparticles can be synthesized, involving a wide variety of reactants used as reducing and stabilizing agents, like polymers and surfactants [14,15].…”

Section: Introductionmentioning

confidence: 99%

Antifungal and Cytotoxic Evaluation of Photochemically Synthesized Heparin-Coated Gold and Silver Nanoparticles

et al. 2020

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Heparin-based silver nanoparticles (AgHep-NPs) and gold nanoparticles (AuHep-NPs) were produced by a photochemical method using silver nitrate and chloroauric acid as metal precursors and UV light at 254 nm. UV–Vis spectroscopy graphs showed absorption for AgHep-NPs and AuHep-NPs at 420 nm and 530 nm, respectively. TEM revealed a pseudospherical morphology and a small size, corresponding to 10–25 nm for AgHep-NPs and 1.5–7.5 nm for AuHep-NPs. Their antifungal activity against Candida albicans, Issatchenkia orientalis (Candida krusei), and Candida parapsilosis was assessed by the microdilution method. We show that AgHep-NPs were effective in decreasing fungus density, whereas AuHep-NPs were not. Additionally, the viability of human gingival fibroblasts was preserved by both nanoparticle types at a level above 80%, indicating a slight cytotoxicity. These results are potentially useful for applications of the described NPs mainly in dentistry and, to a lesser extent, in other biomedical areas.

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Applications of Metallic Nanoparticles in Antimicrobial Therapy

Cited by 13 publications

References 241 publications

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications

Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases

Antifungal and Cytotoxic Evaluation of Photochemically Synthesized Heparin-Coated Gold and Silver Nanoparticles

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