Applications of Mesoporous Silica-Encapsulated Gold Nanorods Loaded Doxorubicin in Chemo-photothermal Therapy

Abstract

We investigate the chemo-photothermal effects of gold nanorods (GNRs) coated using mesoporous silica (mSiO 2 ) loading doxorubicin (DOX). When the mesoporous silica layer is embedded by doxorubicin drugs, a significant change in absorption spectra enables to quantify the drug loading. We carried out photothermal experiments on saline and livers of mice having GNRs@mSiO 2 and GNRs@mSiO 2 -DOX. We also injected the gold nanostructures into many tumor-implanted mice and used laser illumination on some of them. By measuring the weight and size of tumors, the distinct efficiency of photothermal therapy and chemotherapy on treatment is determined. We experimentally confirm the accumulation of gold nanostructures in the liver.

Functionalized Mesoporous Silica as Doxorubicin Carriers and Cytotoxicity Boosters

“…Besides using liposomes, nanoparticles [ 3 , 4 , 5 ] or porous scaffolds [ 6 ], administration routes other than per injection are also taken into account, as, for example, oral delivery [ 1 , 2 , 7 ], implantation [ 6 ], dermal administration [ 3 ] and/or combined delivery mechanisms [ 5 ]. The targeted release of Dox can be ensured by the implanting of drug carriers at the site of the tumor.…”

Pillar[5]arene‐Modified Gold Nanorods as Nanocarriers for Multi‐Modal Imaging‐Guided Synergistic Photodynamic‐Photothermal Therapy

“…[10][11][12][13] In order to achieve excellent tumor suppression and minimal side effects of drugs in cancer therapy, burgeoning non-invasive therapeutic strategies have been developed in recent years, including gene therapy, photothermal therapy (PTT), and photodynamic therapy (PDT). 14,15 In these therapeutic strategies, various nanomaterials, such as Au nanoparticles, 16 Pt nanoparticles, 17 upconversion nanoparticles, 18 Fe 3 O 4 nanoparticles, 19 and some typical organic nanomedicines 7 have been used as effective photothermal agents, photosensitizing agents, and photoacoustic contrast agents. [20][21][22] PTT and PDT strategies have minimized the side effects of chemotherapy and operative treatments, but PTT/PDT has obvious defects when used alone.…”

“…Some nanocontainers, such as the supramolecular or polymeric vesicles, [3] mesoporous silica nanoparticles, [4] and metal–organic frameworks, [5] have been utilized as nanocarriers for drug delivery [6] . In order to achieve excellent tumor suppression and minimal side effects of drugs in cancer therapy, burgeoning non‐invasive therapeutic strategies have been developed in recent years, including gene therapy, photothermal therapy (PTT), and photodynamic therapy (PDT) [7] . In these therapeutic strategies, various nanomaterials, such as Au nanoparticles, [8] Pt nanoparticles, [9] upconversion nanoparticles, [10] Fe 3 O 4 nanoparticles, [11] and some typical organic nanomedicines [3c] have been used as effective photothermal agents, photosensitizing agents, and photoacoustic contrast agents [12] .…”

Mesoporous silica shell-coated single gold nanorods as multifunctional orientation probes in dynamic biological environments

“…11 Furthermore, they can be used for synergistic phototherapy and chemotherapy combination using the mesoporous silica pores as reservoirs for chemotherapeutics owing to their high loading capacity, while the AuNRs serve as a local heat generator to induce phototherapy and trigger drug release. [11][12][13][14][15][16] AuNRs have also been effectively used as orientation probes with a few polarization-based optical techniques, including dark-eld (DF) polarization microscopy, 17 photothermal heterodyne imaging (PHI), 18 differential interference contrast (DIC) polarization anisotropy, 1,19 and total internal reection (TIR) scattering microscopy. [20][21][22] Therefore, AuNRs@mSiO 2 can be used as multifunctional optical probes in biological studies.…”