Abstract:The path to a new therapeutic drug is long and difficult and involves many stages including validation of a target, design and selection of a lead compound and finally development of the lead into a drug. This chapter will discuss a relatively new technology that makes use of small molecules termed activity based probes (ABPs). These probes bind in the active site of a target enzyme or class of enzymes in an activity dependent fashion. Thus probe labeling serves as an indirect readout of enzyme activity, allow… Show more
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