Applications, advancements, and challenges of 3D bioprinting in organ transplantation

Huang, Guobin; Zhao, Yuanyuan; Chen, Dong; Wei, Lai; Hu, Zhiping; Li, Junbo; Zhou, Xi; Yang, Bo; Chen, Zhishui

doi:10.1039/d3bm01934a

Biomater. Sci.

2024

DOI: 10.1039/d3bm01934a

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Applications, advancements, and challenges of 3D bioprinting in organ transplantation

Guobin Huang,

Yuanyuan Zhao,

Dong Chen

et al.

Abstract: To date, organ transplantation remains an effective method for treating end-stage diseases of various organs.

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2024

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Cited by 4 publications

References 130 publications

(178 reference statements)

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The cutting‐edge progress in bioprinting for biomedicine: principles, applications, and future perspectives

Liu,

Chen,

Wang

et al. 2024

MedComm

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Bioprinting is a highly promising application area of additive manufacturing technology that has been widely used in various fields, including tissue engineering, drug screening, organ regeneration, and biosensing. Its primary goal is to produce biomedical products such as artificial implant scaffolds, tissues and organs, and medical assistive devices through software‐layered discrete and numerical control molding. Despite its immense potential, bioprinting technology still faces several challenges. It requires concerted efforts from researchers, engineers, regulatory bodies, and industry stakeholders are principal to overcome these challenges and unlock the full potential of bioprinting. This review systematically discusses bioprinting principles, applications, and future perspectives while also providing a topical overview of research progress in bioprinting over the past two decades. The most recent advancements in bioprinting are comprehensively reviewed here. First, printing techniques and methods are summarized along with advancements related to bioinks and supporting structures. Second, interesting and representative cases regarding the applications of bioprinting in tissue engineering, drug screening, organ regeneration, and biosensing are introduced in detail. Finally, the remaining challenges and suggestions for future directions of bioprinting technology are proposed and discussed.Bioprinting is one of the most promising application areas of additive manufacturing technology that has been widely used in various fields. It aims to produce biomedical products such as artificial implant scaffolds, tissues and organs, and medical assistive devices. This review systematically discusses bioprinting principles, applications, and future perspectives, which provides a topical description of the research progress of bioprinting.

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The cutting‐edge progress in bioprinting for biomedicine: principles, applications, and future perspectives

Liu,

Chen,

Wang

et al. 2024

MedComm

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4D printing of biological macromolecules employing handheld bioprinters for in situ wound healing applications

Li,

Zhang,

Sun

et al. 2024

International Journal of Biological Macromolecules

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Vascularized platforms for investigating cell communication via extracellular vesicles

Kim,

Ro,

Cho

2024

Biomicrofluidics

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The vascular network plays an essential role in the maintenance of all organs in the body via the regulated delivery of oxygen and nutrients, as well as tissue communication via the transfer of various biological signaling molecules. It also serves as a route for drug administration and affects pharmacokinetics. Due to this importance, engineers have sought to create physiologically relevant and reproducible vascular systems in tissue, considering cell–cell and extracellular matrix interaction with structural and physical conditions in the microenvironment. Extracellular vesicles (EVs) have recently emerged as important carriers for transferring proteins and genetic material between cells and organs, as well as for drug delivery. Vascularized platforms can be an ideal system for studying interactions between blood vessels and EVs, which are crucial for understanding EV-mediated substance transfer in various biological situations. This review summarizes recent advances in vascularized platforms, standard and microfluidic-based techniques for EV isolation and characterization, and studies of EVs in vascularized platforms. It provides insights into EV-related (patho)physiological regulations and facilitates the development of EV-based therapeutics.

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Applications, advancements, and challenges of 3D bioprinting in organ transplantation

Abstract: To date, organ transplantation remains an effective method for treating end-stage diseases of various organs.

Cited by 4 publications

References 130 publications

The cutting‐edge progress in bioprinting for biomedicine: principles, applications, and future perspectives

The cutting‐edge progress in bioprinting for biomedicine: principles, applications, and future perspectives

4D printing of biological macromolecules employing handheld bioprinters for in situ wound healing applications

Vascularized platforms for investigating cell communication via extracellular vesicles

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