Application of simplified in vitro screening tests to detect genotoxicity of aristolochic acid

Zhang, H.; Cifone, Maria A.; Murli, Hemalatha; Erexson, Gregory L.; Mecchi, Michael S.; Lawlor, Timothy E.

doi:10.1016/j.fct.2004.07.016

Cited by 40 publications

(27 citation statements)

References 23 publications

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“…International Agency for Research on Cancer (IARC) classified herbal remedies containing plant species of the genus Aristolochia as human carcinogens in 2002 [9]. Results from previously published studies showed that the AA mixture was genotoxic in Salmonella typhimurium [1,[10][11][12]. Micronucleus (MCN) induction was detected in CHO cells [1], mouse bone-marrow cells [13], human lymphocytes and human-derived hepatoma (HepG2) cells [14], Furthermore, sister chromatid exchanges and chromosomal abrrations were observed in human lymphocytes and CHO cells [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Genotoxic effect and nitrative DNA damage in HepG2 cells exposed to aristolochic acid

Wu¹,

Jiang²,

Cao³

et al. 2007

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Section: Introductionmentioning

confidence: 99%

“…Aristolochic acid (AA), the basic active component of Aristolochia extracts, was extensively used as a traditional herbal medicine [1]. In earlier studies, Aristolochia species was used to treat gout, arthritis, rheumatism and weight reduction [2,3].…”

Section: Introductionmentioning

confidence: 99%

Genotoxic effect and nitrative DNA damage in HepG2 cells exposed to aristolochic acid

Wu¹,

Jiang²,

Cao³

et al. 2007

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…AAs are found in plants from the Aristolochiaceae family, which are also known to be one of the oldest traditional remedy systems used worldwide (Zhang et al 2004). AAs derived from Aristolochia species occur as a mixture of two structurally related nitrophenanthrene carboxylic acids, including aristolochic acid I (AAI) and aristolochic acid II (AAII) (Figure 1) (IARC 2002).…”

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confidence: 99%

Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach

Abdullah

Diaz

Wesseling

et al. 2016

Food Additives & Contaminants: Part A

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After the incidences of induction of aristolochic acid nephropathy after consumption of herbal weight loss preparations that accidentally contained aristolochic acids (AAs), several countries defined national restrictions on the presence of AAs in food, including plant food supplements (PFS) and herbal products. This study investigates whether the risks associated with exposure to AAs via PFS and herbal products are at present indeed negligible. Data reported in literature on AA levels in PFS and other herbal products and also obtained from a new series of PFS in the present study were used to calculate the estimated daily intakes (EDIs) and corresponding margins of exposure (MOEs). Available literature data revealed that 206 out of 573 samples were found to contain aristolochic acid I (AAI) and/or aristolochic acid II (AAII). The results obtained from recently collected PFS revealed that both AAI and AAII were detected in three out of 18 analysed PFS at levels up to 594.8 and 235.3 µg g -1 , respectively, being in line with the levels reported in literature. The EDIs resulting from intake of these PFS resulted in MOEs that were generally below 10,000, corroborating the priority for risk management. Although these results refer to PFS collected by targeted sampling strategies, the data reveal that AA-containing PFS are still freely available. When considering that the use of these samples may be limited to shorter periods of time, the EDIs might be lower, but MOE values would still be lower than 10,000 for more than 50% of the AA-containing PFS and herbal products. In conclusion, the presence of AAs in PFS and herbal products even several years after instalment of the legal restrictions still raises concern, especially for people who frequently use the respective PFS and herbal products. ARTICLE HISTORY

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“…In the presence of a mutagenic agent, a selective pressure, from a medium depleted in the essential amino acid, results in reverse mutations and the growth of colonies that are simply counted. Several different strains of Salmonella must be used, because each strain individually assays for a particular type of mutagen (i.e., one strain for base pair substitutions and a separate strain for frameshift mutations) (Ramos et al, 2002;Zhang et al, 2004;Marshall, 2007;Ogura et al, 2008).…”

Section: In Vitro Methods For Genotoxicity Assessmentmentioning

confidence: 99%

Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

Ouédraogo

Baudoux

Stévigny

et al. 2012

Journal of Ethnopharmacology

120

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Application of simplified in vitro screening tests to detect genotoxicity of aristolochic acid

Cited by 40 publications

References 23 publications

Genotoxic effect and nitrative DNA damage in HepG2 cells exposed to aristolochic acid

Genotoxic effect and nitrative DNA damage in HepG2 cells exposed to aristolochic acid

Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach

Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

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