Application of random and regular input in analytical separation methods: A critical insight

Kaljurand, Mihkel; Smit, H.C.

doi:10.1016/j.chemolab.2005.04.003

Cited by 6 publications

(1 citation statement)

References 55 publications

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“…The HT technique has been applied in many fields, including time-of-flight mass spectrometry, – Raman, , fluorescence imaging, – ion mobility spectrometry, , and NMR. , In our previous studies, – Hadamard transformation has been successfully applied to capillary electrophoretic separations where the signal-to-noise (S/N) ratios were substantially improved by sample injections according to the PRBS. Nonconventional sampling techniques including correlation and HT methods have been reviewed by Kaljurand and Smit …”

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Applications of Hadamard Transform to Gas Chromatography/Mass Spectrometry and Liquid Chromatography/Mass Spectrometry

et al. 2008

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Successful application of the Hadamard transform (HT) technique to gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS) is described. Novel sample injection devices were developed to achieve multiple sample injections in both GC and LC instruments. Air pressure was controlled by an electromagnetic valve in GC, while a syringe pump and Tee connector were employed for the injection device in LC. Two well-known, abused drugs, 3,4-methylenedioxy-N-methylamphetamine (MDMA) and N, N-dimethyltryptamine (DMT), were employed as model samples. Both of the injection devices permitted precise successive injections, resulting in clearly modulated chromatograms encoded by Hadamard matrices. After inverse Hadamard transformation of the encoded chromatogram, the signal-to-noise (S/N) ratios of the signals were substantially improved compared with those expected from theoretical values. The S/N ratios were enhanced approximately 10-fold in HT-GC/MS and 6.8 in HT-LC/MS, using the matrices of 1023 and 511, respectively. The HT-GC/MS was successfully applied to the determination of MDMA in the urine sample of a suspect.

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