Application of Platelet-Rich Gel to Enhance Wound Healing in the Horse: A Case Report

Iacopetti, Ilaria; Perazzi, Anna; Ferrari, V.; Busetto, Roberto

doi:10.1016/j.jevs.2011.08.012

Cited by 26 publications

(23 citation statements)

References 12 publications

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“…Carter et al [61] and DeRossi et al [62] reported that during equine wound healing PRP gel promoted epithelial differentiation and regeneration. In the same species, a case study reported by Iacopetti et al [63] indicated that topical treatment with autologous PRP enhanced healing of large skin wounds. In contrast to the above findings, evaluation of the effect of PRP on wounds of the distal aspect of forelimb in horses indicated excessive granulation tissue development and a significantly slower wound healing [64].…”

Section: Regenerative Therapies For Skin Wound Managementmentioning

confidence: 99%

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

Borena

Martens

Broeckx

et al. 2015

Cell Physiol Biochem

160

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Mammal skin has a crucial function in several life-preserving processes such as hydration, protection against chemicals and pathogens, initialization of vitamin D synthesis, excretion and heat regulation. Severe damage of the skin may therefore be life-threatening. Skin wound repair is a multiphased, yet well-orchestrated process including the interaction of various cell types, growth factors and cytokines aiming at closure of the skin and preferably resulting in tissue repair. Regardless various therapeutic modalities targeting at enhancing wound healing, the development of novel approaches for this pathology remains a clinical challenge. The time-consuming conservative wound management is mainly restricted to wound repair rather than restitution of the tissue integrity (the so-called “restitutio ad integrum”). Therefore, there is a continued search towards more efficacious wound therapies to reduce health care burden, provide patients with long-term relief and ultimately scarless wound healing. Recent in vivo and in vitro studies on the use of skin wound regenerative therapies provide encouraging results, but more protracted studies will have to determine whether the effect of observed effects are clinically significant and whether regeneration rather than repair can be achieved. For all the aforementioned reasons, this article reviews the emerging field of regenerative skin wound healing in mammals with particular emphasis on growth factor- and stem cell-based therapies.

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Section: Regenerative Therapies For Skin Wound Managementmentioning

confidence: 99%

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

Borena

Martens

Broeckx

et al. 2015

Cell Physiol Biochem

160

View full text Add to dashboard Cite

show abstract

“…Some studies have reported that the single application of PRP is insufficient to induce new capillary formation due to the short biological half-life of growth factors in vivo [16], while other studies have shown that repeated application of PRP was effective [17]. It is possible to apply autologous PRP repeatedly, but we must prepare autologous PRP from patient blood at that time because the lifetime of PRP is within 7 days after purification [1].…”

Section: Discussionmentioning

confidence: 99%

Gelatin hydrogel impregnated with platelet-rich plasma releasate promotes angiogenesis and wound healing in murine model

et al. 2014

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Platelet-rich plasma (PRP) contains numerous growth factors to promote wound healing and angiogenesis. The objective of this study was to explore the efficacy of biodegradable gelatin hydrogel impregnated with PRP releasate (PRPr) in the wound healing process compared with the single application of PRPr prepared from mouse PRP centrifuged by a double-spin method. Gelatin hydrogel disks with an isoelectric point of 5.0 were used in this study. A total of 180 mice (n = 45/group) were randomly assigned to the following 4 experimental groups: control group, biodegradable gelatin hydrogel group, PRPr group and gelatin hydrogel impregnated with PRPr (PRPrG) group. Wound area and epithelialization were compared on days 1, 5, 7, 14 and 21 post-wounding. After complete epithelialization, wound contraction was also evaluated. Neovascularization using immunohistochemical staining of von Willebrand factor was analyzed on day 14. The wound area of PRPrG on days 5, 7 and 14 was smaller than that in the other groups (p < 0.01). The epithelialization lengths of PRPrG on days 7 and 14 were significantly longer than the others (p < 0.01). The capillary formation of PRPrG was also superior to those in all other groups on day 14. On day 21, all wounds were completely epithelialized and PRPrG prevented wound contraction the most. It is concluded that the sustained-release system of gelatin impregnated with PRPr can stimulate angiogenesis and accelerate wound healing compared with the single application of PRP.

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“…In vivo-Studien und Fallberichte des Pferdes beschreiben den erfolgreichen Einsatz vom PRP bisher hauptsächlich bei Sehnenläsionen oder zur Förderung der Wundheilung (Carter et al 2003, Maia et al 2009, Bosch et al 2011, Iacopetti et al 2012. Ein In vivo-Modell, durchgeführt an 15 Schafen mit Knorpeldefekt im Kniegelenk, kam zu dem Ergebnis, dass die Kombination von Mikrofrakturierung und PRP-Gel in der histologischen Beurteilung des Knorpels nach 6 Monaten bessere Ergebnisse erzielt, als die Mikrofrakturierung alleine, oder die Kombination mit flüssigem PRP (Milano et al 2010).…”

Section: Platelet-rich Plasmaunclassified

Regenerative and innovative joint medication in the horse – Part 2: Efficacy and adverse effects of joint medication in the horse - A review of the literature - The pathogenesis of osteoarthritis in the horse

Ehrle¹,

Fürst²,

Lischer³

2013

PHK

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Application of Platelet-Rich Gel to Enhance Wound Healing in the Horse: A Case Report

Cited by 26 publications

References 12 publications

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

Gelatin hydrogel impregnated with platelet-rich plasma releasate promotes angiogenesis and wound healing in murine model

Regenerative and innovative joint medication in the horse – Part 2: Efficacy and adverse effects of joint medication in the horse - A review of the literature - The pathogenesis of osteoarthritis in the horse

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