Application of non-metal nanoparticles, as a novel approach, for improving the stability of blood products: 2011–2021

Mehrizi, Tahereh Zadeh; Ardestani, Mehdi Shafiee

doi:10.1007/s40204-022-00188-5

Cited by 7 publications

(2 citation statements)

References 147 publications

(172 reference statements)

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“…In addition, the red blood cell membrane has enormous deformability and can pass through the microvascular system. 39 , 40 Hemolysis rate is the most basic measure of blood compatibility. When nanomaterials come into contact with red blood cells, the surface hydrophobic bonds and irregular shapes may damage the red blood cell membrane, leading to the release of heme and causing hemolysis.…”

Section: Discussionmentioning

confidence: 99%

MRI Directed Magnevist Effective to Study Toxicity of Gd-Doped Mesoporous Carbon Nanoparticles in Mice Model

Zhang,

Shi,

Chang

et al. 2023

IJN

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Purpose Magnetic resonance imaging (MRI) has been a valuable and widely used examination technique in clinical diagnosis and prognostic efficacy evaluation. The introduction of MRI contrast agent (CA) improves its sensitivity obviously, particularly with the development of nano-CA, which presents higher contrast enhancement ability. However, systematical evaluation of their toxicity is still limited, hampering their further translation in clinics. Methods In this paper, to systematically evaluate the toxicity of nano-CA, Gd-doped mesoporous carbon nanoparticles (Gd-MCNs) prepared by a one-step hard template method were introduced as a model and clinically used MRI CA, Magnevist (Gd-DTPA) as control. Their in vitro blood compatibility, cellular toxicity, DNA damage, oxidative stress, inflammation response as well as in vivo toxicity and MR imaging behaviors were studied and compared. Results The experimental results showed that compared with Gd-DTPA, Gd-MCNs displayed negligible influence on the red blood cell shape, aggregation, BSA structure, macrophage morphology and mitochondrial function. Meanwhile, limited ROS and inflammatory cytokine production also illustrated the cellular compatibility of Gd-MCNs. For in vivo toxicity evaluation, Gd-MCNs presented acceptable in vivo biosafety even under 12 times injection for 12 weeks. More importantly, at the same concentration of Gd, Gd-MCNs displayed better contrast enhancement of tumor than Gd-DTPA, mainly coming from its high MRI relaxation rate which is nearly 9 times that of Gd-DTPA. Conclusion In this paper, we focus on the toxicity evaluation of MRI nano-CA, Gd-MCNs from different angles. With Gd-DTPA as control, Gd-MCNs appeared to be highly biocompatible and safe nanoparticles that possessed promising potentials for the use of MRI nano-CA. In the future, more research on the long-term genotoxicity and the fate of nanoparticles after being swallowed should be performed.

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Section: Discussionmentioning

confidence: 99%

MRI Directed Magnevist Effective to Study Toxicity of Gd-Doped Mesoporous Carbon Nanoparticles in Mice Model

Zhang,

Shi,

Chang

et al. 2023

IJN

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“…Nanoparticles have become one such topic deserving close attention. Their huge variety (inorganic nanoparticles, organic nanoparticles, ceramic nanoparticles, and carbon-based nanoparticles [1][2][3][4][5][6]), biosynthesis simplicity, and remarkable physicochemical, biological, and catalytic properties can literally open a new era for the creation of modern drugs solving different biomedical tasks. The biological synthesis of nanoparticles by living organisms-bacteria, fungi, and plants [7]-is an inexhaustible source of medicines that enable the solving of large-scale problems in the treatment of various diseases-bacterial and viral infections, oncological diseases, parasitic invasions, inflammatory processes, diabetes, and also in biosensing, bioimaging, drug delivery, diagnostics, etc.…”

Section: Introductionmentioning

confidence: 99%

Selenium Nanoparticles: Green Synthesis and Biomedical Application

Mikhailova

2023

Molecules

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Selenium nanoparticles (SeNPs) are extremely popular objects in nanotechnology. “Green” synthesis has special advantages due to the growing necessity for environmentally friendly, non-toxic, and low-cost methods. This review considers the biosynthesis mechanism of bacteria, fungi, algae, and plants, including the role of various biological substances in the processes of reducing selenium compounds to SeNPs and their further packaging. Modern information and approaches to the possible biomedical use of selenium nanoparticles are presented: antimicrobial, antiviral, anticancer, antioxidant, anti-inflammatory, and other properties, as well as the mechanisms of these processes, that have important potential therapeutic value.

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