“…These results indicated that the prepared collagen liposomes are biologically safe, and the experimental results provided a certain reference for the application of collagen liposomes in cosmetics and pharmaceutical fields as a natural and safe raw material. 57 Figure 6 Effect of collagen liposomes on the viability of BV2 cells. …”
Purpose
In the present study, we prepared collagen liposomes with the addition of polyol, which is expected to not only increase the solubility of collagen but also improve skin penetration.
Methods
Collagen liposomes were prepared by the film dispersion method, and their characteristics, integrity and biosafety were evaluated by Fourier transform infrared spectroscopy (FTIR), UV-VIS spectroscopy, polyacrylamide gel electrophoresis (SDS-PAGE), dynamic light scattering (DLS) and transmission electron microscope (TEM). The transdermal absorption of collagen and collagen liposomes were tested by an ex vivo horizontal Valia-Chien diffusion cell system.
Results
We first demonstrated that collagen extracted from bovine Achilles tendon was type I collagen. The results of DLS measurement and TEM observation showed that the collagen liposomes were spherical in shape with average diameter (75.34±0.93 nm) and maintained high stability at low temperature (4°C) for at least 42 days without toxicity. The encapsulation rate of collagen liposomes was 57.80 ± 0.51%, and SDS-PAGE analysis showed that collagen was intact in liposomes. Finally, permeability studies indicated that the collagen-loaded liposomes more easily penetrated the skin compared to collagen itself.
Conclusion
This study proposed a new method to improve the bioavailability and permeability of bovine type I collagen, which improves the applicability of collagen in biomedicine, cosmeceuticals and pharmaceutical industries.
“…These results indicated that the prepared collagen liposomes are biologically safe, and the experimental results provided a certain reference for the application of collagen liposomes in cosmetics and pharmaceutical fields as a natural and safe raw material. 57 Figure 6 Effect of collagen liposomes on the viability of BV2 cells. …”
Purpose
In the present study, we prepared collagen liposomes with the addition of polyol, which is expected to not only increase the solubility of collagen but also improve skin penetration.
Methods
Collagen liposomes were prepared by the film dispersion method, and their characteristics, integrity and biosafety were evaluated by Fourier transform infrared spectroscopy (FTIR), UV-VIS spectroscopy, polyacrylamide gel electrophoresis (SDS-PAGE), dynamic light scattering (DLS) and transmission electron microscope (TEM). The transdermal absorption of collagen and collagen liposomes were tested by an ex vivo horizontal Valia-Chien diffusion cell system.
Results
We first demonstrated that collagen extracted from bovine Achilles tendon was type I collagen. The results of DLS measurement and TEM observation showed that the collagen liposomes were spherical in shape with average diameter (75.34±0.93 nm) and maintained high stability at low temperature (4°C) for at least 42 days without toxicity. The encapsulation rate of collagen liposomes was 57.80 ± 0.51%, and SDS-PAGE analysis showed that collagen was intact in liposomes. Finally, permeability studies indicated that the collagen-loaded liposomes more easily penetrated the skin compared to collagen itself.
Conclusion
This study proposed a new method to improve the bioavailability and permeability of bovine type I collagen, which improves the applicability of collagen in biomedicine, cosmeceuticals and pharmaceutical industries.
“…Nanoencapsulation of phytocompounds is proven to prolong stability, enhance solubility, as well as preserve the therapeutic benefits of the extracts [79]. Additionally, nanoencapsulation improves local and controlled skin delivery of ingredients and enhances the sensory properties of cosmetic products [80]. These three main advantages of nanoencapsulation of natural substances support and trigger the increasing trend of nanotechnology application in natural cosmetics.…”
Section: Application Of Nanotechnology-incorporated Natural Ingredientsmentioning
confidence: 97%
“…In fact, there are a lot of commercialized products in the market which implement nanoparticles for value and benefits enhancement. Table 2 summarizes some of the examples of nanoparticle-based commercialized cosmetic products reviewed by Faria-Silva et al [80].…”
Section: Application Of Nanotechnology-incorporated Natural Ingredientsmentioning
Technology and environmental innovations always have a growing emphasis and have affected various industries. Since the cosmetics industry is highly competitive and consumers always desire innovations in products, the cosmetics industry tends to launch new products to satisfy customer desires without exception. Recently, in the area of cosmeceuticals, the application of nanotechnology has been attempting to increase; however, it seems to be tackling certain disadvantages compared to traditional products. Cosmeceuticals based on nanotechnology offer the benefits of product differentiation, improved bioavailability, and prolonged effects of active ingredients. These are widely used as a regulated delivery medium for cosmeceuticals, such as shampoo, nail enamels, lotions, hair serums, and conditioners. Their wide application is attributed to their intrinsic properties, such as rapid penetration, stability, hydrating power, and texture. The ability of the nanoemulsion system to form small- and large-surface nanoparticles enable the bioactive components to be transported into the skin more effectively. Furthermore, natural cosmetics are a general term that refers to all preparations for external conditioning and beautifying of the body from ingredients produced by or found in nature. The purpose of this review is to understand the nature of natural cosmetics which incorporate nanotechnology for better encapsulation and a better drug delivery system. The importance of innovations in the cosmetic industry is also discussed.
“…Moreover, plant-derived cosmeceutical formulations are also gaining popularity because of their long-term health and cosmetic benefits [ 4 ]. Plant-based natural products are wildly used in cosmetic compositions for skin care, hair care, and toiletry preparations because they are generally considered safe and do not predispose consumers to allergic reactions [ 1 , 5 , 6 , 7 ]. Beauty-related cosmetics of plant extracts are due to their antioxidant, antibacterial, wound-healing, antiaging, sun protection, cytoprotective, skin whitening, and anti-inflammatory activities [ 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…Many studies have shown that Lilium is rich in amino acids; polysaccharides; and bioactive components such as phenolics, flavonoids, and saponins, which are important sources of natural products [ 9 , 10 , 11 , 12 , 13 ]. These compounds have proven to exert numerous health benefits, such as anti-inflammatory [ 14 ], antitumor [ 15 ], hypoglycemic [ 16 , 17 , 18 ], and antidepressant [ 19 ] effects, as well as ultraviolet (UV) absorption, free radical scavenging, carcinogenesis inhibition, wrinkling, and other skin care effects [ 4 , 5 , 20 ]. Antioxidant and ultraviolet absorption capacities are important evaluation indexes for the superiority and inferiority of cosmetic products [ 21 ].…”
The application of cosmetics is indispensable in our current society. In recent years, with an increasing awareness of the long-term health benefits of naturally sourced ingredients, plant-based cosmetic products have gained increasing attention. Lilium belongs to the Liliaceae family, which is one of the main plant families used in cosmetics for skin care treatment. A large number of studies have shown that Lilium plants are rich in components such as phenolic acids, flavonoids, and polysaccharides, with high potential for cosmetic applications. However, the application of lilies in cosmetics has not been systematically reported. This knowledge gap can easily lead to the neglect of its application in cosmetics because lilies are most familiar as ornamental plants. Integrating academic papers and patent publications, we analyzed the potential cosmetic application ingredients in lily, as well as their applications in cosmetics and related efficacy. Patent analysis showed that applications for lily-related cosmetic patents are mainly concentrated in East Asia, including China, Korea, and Japan. The application of lilies involves all aspects of cosmetics, such as sunscreens, facial cleansers, facial masks, conditioners, and so on. Its functions are also rich and diverse, including antiaging, radiation protective, whitening, moisturizing, freckle removal, acne treatment, and hair regeneration promotion. In addition, lilies are compatible with the application of other herbs. Moreover, with a change in people’s consumption concepts and the consideration of long-term health benefits, lily-based food and medicine innovation with health care and beautification effects may be a promising direction.
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