Application of nanotechnology for development of cosmetics

Chuo, Sing Chuong; Setapar, Siti Hamidah Mohd

doi:10.1016/b978-0-12-822967-5.00004-7

Cited by 1 publication

(1 citation statement)

References 62 publications

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“…The use of biodiversity to search for bioactive compounds has gained increasing importance, enabling the development of effective, accessible and safe alternatives for the prevention and treatment of various conditions that affect human health [ 1 , 2 ]. Related to this context, the development of nanotechnology has represented a leap in science, bringing benefits such as physical-chemical stabilization of bioactive molecules, improved solubility and bioavailability, decreased toxicity, as well as potentiation of biological activities, providing applications in the pharmaceutical, food and cosmetics industries [ 3 , 4 , 5 ]. Among the nanotechnologies, the production and use of nanocarriers stand out as systems to transport bioactive molecules with applications in cosmetics, involving compounds of lipids, polymers or inorganic materials [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System

et al. 2023

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In recent years, lycopene has been highlighted due to its antioxidant and anti-inflammatory properties, associated with a beneficial effect on human health. The aim of this study was to advance the studies of antioxidant and anti-inflammatory mechanisms on human keratinocytes cells (HaCaT) of a self-emulsifying drug delivery system (SEDDS) loaded with lycopene purified from red guava (nanoLPG). The characteristics of nanoLPG were a hydrodynamic diameter of 205 nm, a polydispersity index of 0.21 and a zeta potential of −20.57, providing physical stability for the nanosystem. NanoLPG demonstrated antioxidant capacity, as shown using the ORAC methodology, and prevented DNA degradation (DNA agarose). Proinflammatory activity was evaluated by quantifying the cytokines TNF-α, IL-6 and IL-8, with only IL-8 showing a significant increase (p < 0.0001). NanoLPG showed greater inhibition of the tyrosinase and elastase enzymes, involved in the skin aging process, compared to purified lycopene (LPG). In vitro treatment for 24 h with 5.0 µg/mL of nanoLPG did not affect the viability of HaCaT cells. The ultrastructure of HaCaT cells demonstrated the maintenance of morphology. This contrasts with endoplasmic reticulum stresses and autophagic vacuoles when treated with LPG after stimulation or not with LPS. Therefore, the use of lycopene in a nanoemulsion may be beneficial in strategies and products associated with skin health.

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