Application of multivariate analysis to the screening of molecularly imprinted polymers for bisphenol A

Influence of salt ions on binding to molecularly imprinted polymers

“…More recently, several promising methods to approach the optimization problem in a more systematic way have been demonstrated. Chemometrical approaches, combinatorial synthesis, high-throughput screening, and computational methods have been applied to investigate factors of importance in the synthesis protocol and to expedite the optimization of polymer compositions towards high selective rebinding of the template [4][5][6][7][8][9][10][11][12][13][14][15].…”

Polímeros biomiméticos em química analítica. Parte 1: preparo e aplicações de MIP ("Molecularly Imprinted Polymers") em técnicas de extração e separação

“…O etileno glicol dimetacrilato (EGDMA) tem sido o reagente de ligação cruzada mais utilizado, pois promove a formação de polímeros térmica e mecanicamente estáveis e com rápida transferência de massa. Outros reagentes de ligação cruzada têm sido investigados (Figura 5), mas apenas o trimetilpropano trimetacrilato (TRIM) tem apresentado resultados similares ou melhores que o EGDMA 45,46 .…”

Synthesis, optimization, and characterization of molecularly imprinted nanoparticles

“…The main disadvantages of this approach are that it needs high number of experiments and it does not consider any possible interaction between the studied variables. To overcome this shortcoming, multivariate optimization methods are considered as promising techniques which use experimental design in conjunction with multivariate analysis techniques to optimize different processes [19][20][21][22]. Zhu et al [19] investigated the influence of process parameters on the preparation of vinblastine-imprinted polymers.…”

“…The optimal conditions were achieved by the regression model, and the results demonstrated that the performance of the imprinted polymer improved by optimizing the polymerization parameters. Experimental design and partial least square model have been employed in order to optimize the synthesis of bisphenol A selective MIPs [20]. The findings revealed that the photoinitiated polymers yield the highest specific binding capacity.…”