Application of experimental design and multivariate analysis in the on-line reaction monitoring of a Suzuki cross-coupling reaction by Raman spectroscopy and multivariate analysis

Real-time visualization of the Suzuki reaction using surface enhanced Raman spectroscopy and a moveable magnetic nanoparticle film

“…S3a, ESI†). 30 However, when the reaction time was prolonged at 90 °C, no significant change was observed in intensity at 1595 cm −1 . It was revealed that the formation of byproducts was critically relevant to the initial instability of the reaction temperature.…”