Application of equilibrium theory to ternary moving bed configurations (four+four, five+four, eight and nine zones)

Nicolaos, Alexandre; Muhr, Laurence; Gotteland, Patrice; Nicoud, Roger‐Marc; Bailly, M.

doi:10.1016/s0021-9673(00)00937-7

Cited by 67 publications

(29 citation statements)

References 21 publications

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“…The common approach for such multicomponent process is the simple application of SMB cascades [73,[125][126][127][128] or the use of internal loops with enrichment stages in sequential (eight sections) SMB units [129]. Nonetheless, there are also nonconventional SMB operation solutions that allow the achievement of more than two high-purity products in the same unit, as the one commercialized by the Japan Organo Co.…”

Section: Multicomponent Separationsmentioning

confidence: 99%

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Gomes

Rodrigues

2011

Chem Eng & Technol

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This work presents a comprehensive insight about simulated moving bed (SMB) technology, from concept to unit operation and process demonstration. A particular relevance is given to SMB nonconventional modes of operation, modeling, and design of SMB-based separations as well as to the construction and operation of SMB units. A conventional separation of a racemic mixture of (S,R)-a-tetralol by means of the FlexSMB-LSRE® unit is addressed to better exemplify a state-ofthe-art SMB lab-scale process development and demonstration.

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Section: Multicomponent Separationsmentioning

confidence: 99%

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Gomes

Rodrigues

2011

Chem Eng & Technol

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“…These new operation modes do not keep constant conditions during one switching period, as in a standard SMB, but allow for variation of the column configuration, the feed flowrates, the feed concentration, and the withdrawal time of products, respectively. Classical four-zone SMB was only capable of separating binary mixtures or dividing multi-component mixtures into strong adsorbing and weak adsorbing fractions (Wang and Ching 2005), while five-zone (Nicolaos et al 2001a(Nicolaos et al , 2001bWang and Ching 2005;Xie et al 2005) and nine-zone (Wooley et al 1998) SMB processes were presented for multi-component separations of more than three components.…”

Section: Bmentioning

confidence: 99%

Effect of dead volume on performance of simulated moving bed process

Lim

Bhatia

2010

Adsorption

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The volume of surrounding equipments (pipe transfer lines and valves) in the simulated moving bed (SMB) unit, which is called the dead volume, is modeled as bed-head, bed-tail and bed-line. Since the dead volume can be significant especially in industrial-scale SMB units, the consideration of dead volume has been required for high performance operation. In this study, a simple and unified approach based on the method of characteristics (MOC), called the extended node model, is established to solve fluid concentration dynamics within dead volumes. The computational efficiency of the approach is evaluated for three case studies of a standard four-zone SMB process with a linear adsorption equilibrium model. Insertion of one zone to flush the fluid trapped in extract bed-line into the standard fourzone SMB improves substantially purity, while recovery is kept constant.

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“…Seven different cascades applicable to separate a ternary mixture and based on up to 14 zones were presented in [83]. A detailed theoretical analysis of various schemes capable of separating ternary mixtures was performed applying equilibrium theory [84,85]. In these studies, linear as well as nonlinear adsorption isotherms were considered.…”

Section: G Ternary and Pseudo-ternary Separationsmentioning

confidence: 99%

“…12, right) simulated for the case of linear isotherms. Due the fact that the combination of closed loops and complete internal recycling of one outlet stream (here the effluent between zones V and VI) does not allow all mass balance constraints to be met [84], an additional solvent reduction step is implemented (see section D above), thus rendering complete separation possible [88]. Such a continuous concentration step offers the additional advantage of increasing product concentrations in the streams leaving the lower subunit.…”

Section: G Ternary and Pseudo-ternary Separationsmentioning

confidence: 99%

New Developments in Simulated Moving Bed Chromatography

2008

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Chromatographic separation processes are widely used to isolate and purify value added products. Most frequently, such separation processes are performed exploiting the principles of injecting samples of the feed mixture in a repetitive periodic manner and collecting the target products batchwise. In the early 1960s, an alternative operation principle based on using several columns connected in series and exploiting a continuous countercurrent movement between the mobile and stationary phases initiated significant improvements in performing specific separation processes in the petrochemical and sugar industries. In the last decade, the so-called simulated moving bed (SMB) chromatography has rapidly entered the pharmaceutical industry. In particular enantioseparations using chiral stationary phases have become a strong driving force to develop more sophisticated concepts of continuous chromatography. Currently, the growing interest in efficient methods for the downstream processing of biomolecules enhances interest in SMB processes. This paper gives a brief overview of the new suggestions and trends. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [accessed July 4, 2008

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Application of equilibrium theory to ternary moving bed configurations (four+four, five+four, eight and nine zones)

Cited by 67 publications

References 21 publications

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Simulated Moving Bed Chromatography: From Concept to Proof‐of‐Concept

Effect of dead volume on performance of simulated moving bed process

New Developments in Simulated Moving Bed Chromatography

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