Application of Dental Pulp Stem Cells for Bone and Neural Tissue Regeneration in Oral and Maxillofacial Region

Abstract

In the oral and maxillofacial region, the treatment of severe bone defects, caused by fractures, cancers, congenital abnormalities, etc., remains a great challenge. In addition, neurological disorders are frequently accompanied by these bone defects or the treatments for them. Therefore, novel bone regenerative techniques and methods to repair nerve injury are eagerly sought. Among them, strategies using dental pulp stem cells (DPSCs) are promising options. Human DPSCs can be collected easily from extracted teeth and are now considered a type of mesenchymal stem cell with higher clonogenic and proliferative potential. DPSCs have been getting attention as a cell source for bone and nerve regeneration. In this article, we reviewed the latest studies on osteogenic or neural differentiation of DPSCs as well as bone or neural regeneration methods using DPSCs and discussed the potential of DPSCs for bone and nerve tissue regeneration.

Fructose vs. Glucose: Modulating Stem Cell Growth and Function Through Sugar Supplementation

“…Our bodies contain various types of stem cells that play a vital role in tissue regeneration and wound healing 45,46 . They greatly vary not only in their origins but also in their potency 6 .…”

The Regeneration in Dentistry with Scaffolds Application

“…The Regeneration in Dentistry with Scaffolds Application brought about a revolutionary change in dental care. The foundation for specialized and highly customized regeneration techniques is laid by this method, which acknowledges and capitalizes on the intrinsic variability within patients' genetic compositions and clinical characteristics [54].…”

“…Through the exploration of the complex subtleties of an individual's genetic makeup, dentists can interpret particular genetic markers, susceptibilities, and predispositions that impact oral health and the capacity for regeneration. The abundance of genetic knowledge enables the creation of exact treatment plans tailored to the unique requirements and complexities of every patient [54]. It gives dental professionals the ability to precisely plan regeneration therapies, guaranteeing the best possible results while lowering the possibility of unfavorable effects or complications [55].…”

Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review

“…Severe oral and maxillofacial bone defects pose significant challenges in terms of treatment. DPSCs may be suitable for regenerative therapy, but further understanding, optimization, and safety considerations are needed [ 25 ]. DPSCs are advantageous due to their ease of access, high extraction efficiency, and versatility.…”