Application of Chitosan in Veterinary Vaccine Production

Albulov, A. I.; Фролова, М. А.; Grin, A.V.; Kovaleva, E. I.; Melnik, N.V.; Krasochko, P.A.

doi:10.1134/s0003683818050034

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…It proved particularly useful in chemotherapy in animals for toxic drugs while delivering in other ways, for example, the heart-toxic anticancer doxorubicin or those with relatively short half-life and duration of action, like opioids [ 98 , 99 , 100 ]. It may also help deliver various immunomodulatory substances, including vaccines, anti-inflammatory agents, or adjuvants that would allow for animal disease control without using chemotherapeutics that are not acceptable for environmental concerns or are less effective due to increasing pathogen resistance [ 34 , 101 , 102 ].…”

Section: Application Of Biodegradable Polymers In Veterinary Medicinementioning

confidence: 99%

Biodegradable Polymers in Veterinary Medicine—A Review

Broda,

Yelle,

Serwańska-Leja

2024

Molecules

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During the past two decades, tremendous progress has been made in the development of biodegradable polymeric materials for various industrial applications, including human and veterinary medicine. They are promising alternatives to commonly used non-degradable polymers to combat the global plastic waste crisis. Among biodegradable polymers used, or potentially applicable to, veterinary medicine are natural polysaccharides, such as chitin, chitosan, and cellulose as well as various polyesters, including poly(ε-caprolactone), polylactic acid, poly(lactic-co-glycolic acid), and polyhydroxyalkanoates produced by bacteria. They can be used as implants, drug carriers, or biomaterials in tissue engineering and wound management. Their use in veterinary practice depends on their biocompatibility, inertness to living tissue, mechanical resistance, and sorption characteristics. They must be designed specifically to fit their purpose, whether it be: (1) facilitating new tissue growth and allowing for controlled interactions with living cells or cell-growth factors, (2) having mechanical properties that address functionality when applied as implants, or (3) having controlled degradability to deliver drugs to their targeted location when applied as drug-delivery vehicles. This paper aims to present recent developments in the research on biodegradable polymers in veterinary medicine and highlight the challenges and future perspectives in this area.

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Section: Application Of Biodegradable Polymers In Veterinary Medicinementioning

confidence: 99%

Biodegradable Polymers in Veterinary Medicine—A Review

Broda,

Yelle,

Serwańska-Leja

2024

Molecules

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“…e results show that the keyword "vaccine" is found in the veterinary sciences category, which indicates that a vaccine made from chitosan is under development, and at the time of our study, it was in the animal testing stage. For example, chitosan succinate has been applied as an adjuvant that is added to a vaccine against animal necrobacteriosis [64]. Using chitosan succinate solution as a protective medium for drying in the production of a dried inactivated vaccine against infectious bovine rhinotracheitis could preserve the biopreparation's high immunogenic activity.…”

Section: Factor and Cluster Map Of Emergentmentioning

confidence: 99%

Chitosan Biomedical Applications for the Treatment of Viral Disease: A Data Mining Model Using Bibliometric Predictive Intelligence

Klongthong

Muangsin

Gowanit

et al. 2020

Journal of Chemistry

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Chitosan has attracted increasing attention from researchers in the pharmaceutical and biomedical fields as a potential agent for the prevention and treatment of infectious diseases. However, identifying the development of emerging technologies related to this biopolymer is difficult, especially for newcomers trying to understand the research streams. In this work, we designed and implemented a research process based on a bibliometric predictive intelligence model. Our aim is to glean detailed scientific and technological trends through an analysis of publications that include certain word phrases and related research areas. Cross correlation, factor mapping, and the calculation of “emergent” scores were also used. A total of 1,612 scientific papers on chitosan technology related to viral disease treatment published between 2010 and 2020 were retrieved from the Web of Science. Results from the keyword modelling quantitatively highlight three major frontier research and development topic groups: drug delivery and adjuvants, vaccines and immune response, and tissue engineering. More specifically, the emergent scores show that much of the chitosan-based treatment for viral diseases is in the in vitro stage of development. Most chitosan applications are in pharmacology/pharmacy and immunology. All results were confirmed by experts in the field, which indicates that the validated process can be applied to other fields of interest.

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