Application of Akaike information criterion to evaluate warfarin dosing algorithm

Plasma vitamin K concentrations depend on CYP4F2 polymorphism and influence on anticoagulation in Japanese patients with warfarin therapy

“…However, earlier studies have reported a lower contribution of the CYP4F2 polymorphism to dosage variability than that by the VKORC1 and CYP2C9 polymorphisms [26]. Harada et al reported that the Japanese patients with CYP4F2 TT genotype required approximately 1.2-fold warfarin maintenance dose compared to those with the CC and CT genotypes, a result that is similar in the present study; however, no significant association between the CYP4F2 genotypes and warfarin maintenance dose was observed [23]. In addition, Cha et al demonstrated a relatively smaller contribution of the CYP4F2 polymorphism to warfarin dose variation in the Japanese population [21].…”

“…Some studies have demonstrated that the CYP4F2 rs2108622 polymorphism accounts for approximately 2%-7% of the inter-individual warfarin dose variability [5,22]. However, some studies have also demonstrated that the effect of the CYP4F2 rs2108622 polymorphism on warfarin response is nonsignificant [23][24][25]. In addition, a recent meta-analysis on the impact of the CYP4F2 polymorphism on coumarin dose requirements suggests a lower contribution of this polymorphism than that of the VKORC1 and CYP2C9 polymorphisms [26].…”

Gender differences in alcohol-induced neurotoxicity and brain damage

“…Gender differences were analysed by two-way ANOVA with a Tukey's post hoc comparison test. Additionally, we performed a multiple linear regression analysis using a stepwise backwards model selection algoritm based in Akaike's information criterion (AIC) (Burham and Anderson, 2004;Harada et al, 2010) for factor-variable selection.…”

Identification of Cytochrome P450 Oxidoreductase Gene Variants That Are Significantly Associated with the Interindividual Variations in Warfarin Maintenance Dose

“…Differing results have also been reported in studies of other populations, with predicted CYP4F2 contributions ranging from 0 to 11%. We did not consider the results from these other studies, given that they were conducted on populations from regions other than the United States or northern Europe, such as Italy (Borgiani et al, 2009), Singapore (Singh et al, 2011), and Japan (Harada et al, 2010), and that there are known differences in the extent of genetic polymorphisms in genes relevant to warfarin dose requirement among various populations, even between northern (e.g., Swedish) and southern (e.g., Italian) European populations (Schelleman et al, 2008;Borgiani et al, 2009;Singh et al, 2011). Our results indicate, for the first time, that three common SNPs in the POR gene may contribute to the interindividual variability in warfarin maintenance dose.…”