Appendectomy versus antibiotic treatment for acute appendicitis

Reevaluating Nonoperative Management for Pediatric Uncomplicated Acute Appendicitis

“…Antibiotic-only management and surgical management are not directly comparable in absolute treatment failure, so a noninferiority analysis is essential for interpreting the results. As observed in a recent RCT by St Peter et al and proposed by a Cochrane review, a noninferiority margin of 20% was considered a reasonable threshold to balance the lower efficacy of NOM with its potential benefits. In our analysis, NOM had a 36.6% failure rate in 1 year compared with 7.0% in the operative management group, indicating that appendectomy outperformed antibiotics and surpassed the noninferiority margin of prior RCTs .…”

Reevaluating Nonoperative Management for Pediatric Uncomplicated Acute Appendicitis

“…Antibiotic-only management and surgical management are not directly comparable in absolute treatment failure, so a noninferiority analysis is essential for interpreting the results. As observed in a recent RCT by St Peter et al and proposed by a Cochrane review, a noninferiority margin of 20% was considered a reasonable threshold to balance the lower efficacy of NOM with its potential benefits. In our analysis, NOM had a 36.6% failure rate in 1 year compared with 7.0% in the operative management group, indicating that appendectomy outperformed antibiotics and surpassed the noninferiority margin of prior RCTs .…”

Epidemiology and Outcome of Acute Appendicitis during and before the COVID-19 Pandemic: A Retrospective Single-Center Analysis

“…In previous studies, only antibiotic treatment without surgery was observed to have significantly increased during the pandemic compared with that before the pandemic [ 11 ]. Owing to the limited surgical capacity available during the pandemic period [ 11 ], antibiotic treatment without surgery increased since it could be a suitable choice for treating uncomplicated appendicitis [ 32 , 33 ]. All patients in this study received antibiotics; however, the number of patients who did not undergo surgery did not significantly increase during the pandemic.…”

Risk factors for periappendiceal adhesions in acute appendicitis: a retrospective comparative study

“…Others established simple or complex appendicitis were advised of surgical removal of the appendix. Although urgent appendicectomy is still the recommended treatment for acute uncomplicated appendicitis, antibiotics have been proposed as a single treatment for uncomplicated appendicitis with controversy [4,20,21]. A meta-analysis of appendectomy vs. antibiotic treatment showed that although antibiotic treatment alone can be successful, a failure rate at 1 year was around 25-30% with need for readmission or surgery [22].…”

Reevaluating Nonoperative Management for Pediatric Uncomplicated Acute Appendicitis

“…Antibiotic-only management and surgical management are not directly comparable in absolute treatment failure, so a noninferiority analysis is essential for interpreting the results. As observed in a recent RCT by St Peter et al and proposed by a Cochrane review, a noninferiority margin of 20% was considered a reasonable threshold to balance the lower efficacy of NOM with its potential benefits. In our analysis, NOM had a 36.6% failure rate in 1 year compared with 7.0% in the operative management group, indicating that appendectomy outperformed antibiotics and surpassed the noninferiority margin of prior RCTs .…”

Epidemiology and Outcome of Acute Appendicitis during and before the COVID-19 Pandemic: A Retrospective Single-Center Analysis

“…In previous studies, only antibiotic treatment without surgery was observed to have significantly increased during the pandemic compared with that before the pandemic [ 11 ]. Owing to the limited surgical capacity available during the pandemic period [ 11 ], antibiotic treatment without surgery increased since it could be a suitable choice for treating uncomplicated appendicitis [ 32 , 33 ]. All patients in this study received antibiotics; however, the number of patients who did not undergo surgery did not significantly increase during the pandemic.…”

Risk factors for periappendiceal adhesions in acute appendicitis: a retrospective comparative study

“…Others established simple or complex appendicitis were advised of surgical removal of the appendix. Although urgent appendicectomy is still the recommended treatment for acute uncomplicated appendicitis, antibiotics have been proposed as a single treatment for uncomplicated appendicitis with controversy [4,20,21]. A meta-analysis of appendectomy vs. antibiotic treatment showed that although antibiotic treatment alone can be successful, a failure rate at 1 year was around 25-30% with need for readmission or surgery [22].…”

Reevaluating Nonoperative Management for Pediatric Uncomplicated Acute Appendicitis

“…Antibiotic-only management and surgical management are not directly comparable in absolute treatment failure, so a noninferiority analysis is essential for interpreting the results. As observed in a recent RCT by St Peter et al and proposed by a Cochrane review, a noninferiority margin of 20% was considered a reasonable threshold to balance the lower efficacy of NOM with its potential benefits. In our analysis, NOM had a 36.6% failure rate in 1 year compared with 7.0% in the operative management group, indicating that appendectomy outperformed antibiotics and surpassed the noninferiority margin of prior RCTs .…”

Epidemiology and Outcome of Acute Appendicitis during and before the COVID-19 Pandemic: A Retrospective Single-Center Analysis

“…In previous studies, only antibiotic treatment without surgery was observed to have significantly increased during the pandemic compared with that before the pandemic [ 11 ]. Owing to the limited surgical capacity available during the pandemic period [ 11 ], antibiotic treatment without surgery increased since it could be a suitable choice for treating uncomplicated appendicitis [ 32 , 33 ]. All patients in this study received antibiotics; however, the number of patients who did not undergo surgery did not significantly increase during the pandemic.…”

Risk factors for periappendiceal adhesions in acute appendicitis: a retrospective comparative study

“…Others established simple or complex appendicitis were advised of surgical removal of the appendix. Although urgent appendicectomy is still the recommended treatment for acute uncomplicated appendicitis, antibiotics have been proposed as a single treatment for uncomplicated appendicitis with controversy [4,20,21]. A meta-analysis of appendectomy vs. antibiotic treatment showed that although antibiotic treatment alone can be successful, a failure rate at 1 year was around 25-30% with need for readmission or surgery [22].…”