Appearance of basophils in the sputum of patients with bronchial asthma

Kimura, Ikuo; Tanizaki, Yoshiro; Saito, Katsuyoshi; Takahashi, Kiyoshi; Ueda, Nobuo; Sato, Shuichi

doi:10.1111/j.1365-2222.1975.tb01840.x

Cited by 74 publications

(23 citation statements)

References 4 publications

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“…Basophils have been found in nasal se cretions by some investigators [6] but not by others [11], If cells were the only source of the histamine found in nasal secretions, they must have been present in larger num bers in nasal secretions than in blood, and their numbers must fluctuate rapidly in nor mals and allergies. Neither possibility seems likely, although the findings of Kimura et al [16] that basophils may be found in asth matic sputum collected during acute symp toms but not during symptomatic periods would suggest that basophilic chemotactic factors exist and could cause fluctuations in basophil content in sputum. Further studies comparing cytology and histamine determi nations are needed to determine what pro portion of histamine in nasal secretions is extracellular.…”

Section: Discussionmentioning

confidence: 68%

“…Bronchial secretions have been shown to contain appreciable numbers of cells in primates [21] and humans [16,22]. Basophils have been found in nasal se cretions by some investigators [6] but not by others [11], If cells were the only source of the histamine found in nasal secretions, they must have been present in larger num bers in nasal secretions than in blood, and their numbers must fluctuate rapidly in nor mals and allergies.…”

Section: Discussionmentioning

confidence: 99%

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Histamine in Nasal Secretions

Pa¹,

Hendley

et al. 1978

Int Arch Allergy Immunol

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The histamine content of secretions collected by small-volume nasal washes was assayed by a spectrophotofluorometric method. A wide range of histamine concentrations (< 5–1, 519 ng/ml) was found. The mean concentration in secretions from normal individuals (91 ng/ml) was not significantly different from that found in allergic individuals (51 ng/ml). Females had significantly lower concentrations than did males. Sequential sampling in normals and allergies showed a great deal of daily variation in histamine content. This technically simple method may prove useful in examining the epidemiology and pathophysiology of allergic rhinitis.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Histamine in Nasal Secretions

Pa¹,

Hendley

et al. 1978

Int Arch Allergy Immunol

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“…Histamine-containing cells have been demon strated in bronchial secretions [9][10][11], and histamine release from these cells can be induced by a variety of stimuli. IgE-mediated release of histamine into nasal secretions [12] might be expected to occur in patients with allergic rhinitis.…”

mentioning

confidence: 99%

Histamine in Nasal Secretions and Serum May Be Elevated during Viral Respiratory Tract Infections

Smith¹,

Remigio²

1982

Int Arch Allergy Immunol

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This study investigated histamine concentration in nasal secretions from children who had viral respiratory tract infection. It demonstrated that (1) there may be appreciable histamine in nasal secretions during viral respiratory tract infection; (2) concentration of histamine in serum may be elevated at the same time; and (3) children with past medical or family history of atopy had more histamine in nasal secretions during viral infections than did nonatopic children.

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“…It is not clear at present whether basophils play a causative role in asthmatic attacks. However, their participation is suggested by the findings of Kimura et al (10,11) who showed that circulating basophils increase in number during the preattack stage of bronchial asthma and fall during attacks with a concomitant rise in the number of basophils in the sputum of patients.…”

mentioning

confidence: 89%

Enhancement of basophil chemotaxis in vitro by virus-induced interferon.

Lett-Brown¹,

Aelvoet²,

Hooks³

et al. 1981

J. Clin. Invest.

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A B S T R A C T It is well established that viral infections may precipitate or worsen attacks of bronchial asthma. Furthermore, in symptomatic atopic subjects, the local accumulation of basophils and the production ofa basophil chemotactic factor have been reported. We have investigated the effect ofcell-free supernates from viral stimulated cultures of human mononuclear cells on the in vitro migration of human basophils. Our results show the presence of a factor in these culture supernates that enhances the migration of basophils toward two separate chemoattractants, a peptide from C5 and a lymphokine. The enhancing activity, while affecting basophil migration, did not change the response of monocytes.The enhancing activity resembled viral-induced interferon when (a) pH 2 stability, (b) heat resistance, (c) trypsin sensitivity, and (d) species-specificity were compared. Finally, the enhancing activity for basophil chemotaxis and the interferon titer were highly correlated in preparations with a 104-fold difference in interferon specific activity.Our studies show that viral-induced interferon can augment the in vitro chemotactic response ofbasophils. Because mediators present in basophils may be involved in the pathogenesis of immediate hypersensitivity, the modulation of basophil movement by interferon suggests a possible mechanism for the association between viral infections and atopic disorders.

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Appearance of basophils in the sputum of patients with bronchial asthma

Cited by 74 publications

References 4 publications

Histamine in Nasal Secretions

Histamine in Nasal Secretions

Histamine in Nasal Secretions and Serum May Be Elevated during Viral Respiratory Tract Infections

Enhancement of basophil chemotaxis in vitro by virus-induced interferon.

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