Apoptotic nature of erythrocyte hemolysis induced by low doses of ionizing radiation

Krylov, V. N.; Дерюгина, А. В.; Плескова, С. Н.; Kalinin, V.

doi:10.1134/s0006350915010170

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…There is other research that also studied the effects of low-dose ionizing radiation on RBC damage. Krylov et al 2015 showed that β-ionizing radiation ( 90 Sr-90 Y source) in the dose range from 0.08 to 0.16 mGy contributed to the deceleration of hemolysis and the stabilization of rat red blood cells 35 of hemolysis could be distinguished in five and three characteristic periods for RBCs isolated from healthy people and people with diabetes, respectively 36 .It is obvious that there are several factors contributing to the RBC response to ionizing radiation:the type of radiation (β-, γ-, X-rays), the radiation dose, and the characteristics of the cells (animal or human cells, normal or abnormal cells). Therefore, our in vitro data using hemolysis as the biological endpoint suggested that the medical diagnostic low-dose X-rays (energy of 80 kVp) did not induce harmful effects on human RBCs.…”

Section: Discussionmentioning

confidence: 99%

Effects of Medical Diagnostic X-rays Delivered at 0.01 or 0.05 mGy on Human Blood Cells

Supawat

Tinlapat

Wongmahamad

et al. 2021

Bangladesh J Med Sci

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Background: Low-dose X-rays are commonly used in medical imaging to help in the diagnosis ofdiseases. However, the deleterious effects of exposure to medical diagnostic low-dose X-rays remaina highly debated topic. The objective was to study the effects of medical diagnostic X-rays on humanblood cells. Materials and Methods: We studied the effects of medical diagnostic low-dose X-rays (80kVp), i.e.,0.01 or 0.05 mGy, after the in vitro exposure of human red blood cells (RBCs) and peripheralblood mononucleated cells (PBMCs).Cells with no irradiation served as the control group. The biologicalendpoints that were used to determine the effects of medical diagnostic low-dose X-rays were hemolysisfor RBCs and mitochondrial membrane potential, lysosomes, and the cell cycle for PBMCs. Results: Ourresults showed no changes in the hemolysis of RBCs and mitochondrial membrane potential, lysosome, orcell cycle in cells exposed to these low doses of X-rays when compared to the corresponding nonirradiatedcells at all harvest timepoints. Conclusion: These results suggested that there were no deleterious effectsof diagnostic low-dose X-rays when human RBCs and PBMCs were exposed in vitro. Bangladesh Journal of Medical Science Vol.20(1) 2021 p.136-144

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Section: Discussionmentioning

confidence: 99%

Effects of Medical Diagnostic X-rays Delivered at 0.01 or 0.05 mGy on Human Blood Cells

Supawat

Tinlapat

Wongmahamad

et al. 2021

Bangladesh J Med Sci

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“…MDA concentration was assessed by the formation of colored trimethine complex with absorption maximum at 532 nm [6]. The molar extinction coefficient E=1.56•10 -5 М -1 •cm -1 was used to calculate concentration.…”

Section: Methodsmentioning

confidence: 99%

The Capabilities of Interference Microscopy in Studying the in vitro State of Erythrocytes Exposed to Low-Intensity Laser Radiation for Stress Correction

Deryugina¹,

Ivashchenko²,

Ignatiev³

et al. 2018

Sovrem Tehnol Med

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The aim of the investigation was to study the corrective action of low-intensity laser radiation on the in vitro morphofunctional state of stressed erythrocytes using interference microscopy. Materials and Methods. Blood samples of intact and stressed rats exposed to low-intensity laser radiation (LILR) were studied in experiments in vitro. The wavelength of LILR radiation was 890 nm. Erythrocyte morphology was studied using laser interference microscopy, malondialdehyde and adenosine triphosphate concentrations were assessed spectrophotometrically. Results. The action of LILR was found to cause no significant changes in the discoid form of erythrocytes and cellular metabolic processes, though it resulted in the appearance of projections on the surface. Exposure to stress promoted a decrease in discocyte count and a significant increase in echinocytes, stomatocytes and degenerative forms of cells with altered microrelief, which was combined with an increase in oxidation processes. The effect of LILR on blood samples of stressed animals led to a decrease in pathological forms of erythrocytes and restoration of cell surface architectonics.

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Functional and Biochemical Parameters of Erythrocytes during Mexicor Treatment in Posttraumatic Period after Experimental Blood Loss and Combined Traumatic Brain Injury

et al. 2017

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Mexicor treatment (8 mg/kg body weight per day) during the posttraumatic period after concomitant traumatic brain injury and acute blood loss in rats increased electrophoretic mobility and concentration of 2,3-diphosphoglycerate, and reduced malondialdehyde content in erythrocytes. These changes improved hemodynamics and oxygen-transporting function of the blood. The most pronounced effects of Mexicor were observed at the early stages of posttraumatic period.

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Apoptotic nature of erythrocyte hemolysis induced by low doses of ionizing radiation

Cited by 7 publications

References 12 publications

Effects of Medical Diagnostic X-rays Delivered at 0.01 or 0.05 mGy on Human Blood Cells

Effects of Medical Diagnostic X-rays Delivered at 0.01 or 0.05 mGy on Human Blood Cells

The Capabilities of Interference Microscopy in Studying the in vitro State of Erythrocytes Exposed to Low-Intensity Laser Radiation for Stress Correction

Functional and Biochemical Parameters of Erythrocytes during Mexicor Treatment in Posttraumatic Period after Experimental Blood Loss and Combined Traumatic Brain Injury

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