Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements

Sethi, Gautam; Rath, Prangya; Chauhan, Abhishek; Ranjan, Anuj; Choudhary, Renuka; Ramniwas, Seema; Sak, Katrin; Aggarwal, Diwakar; Rani, Isha; Tuli, Hardeep Singh

doi:10.3390/pharmaceutics15020712

Cited by 36 publications

(25 citation statements)

References 99 publications

(110 reference statements)

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“…All of these compounds show antitumor properties. Quercetin and kaempferol induced cell cycle arrest and apoptotic cell death in liver cancer cells, and kaempferol had no effect on normal cells [ 55 , 56 ]. Pinocembrin suppressed proliferation and increased apoptosis in lung cancer cells in vitro, and galangin has the same effect in ovarian cancer cells [ 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

Differential Apoptotic Effects of Bee Product Mixtures on Normal and Cancer Hepatic Cells

et al. 2023

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Most effective anticancer drugs normally generate considerable cytotoxicity in normal cells; therefore, the preferential activation of apoptosis in cancer cells and the reduction of toxicity in normal cells is a great challenge in cancer research. Natural products with selective anticancer properties used as complementary medicine can help to achieve this goal. The aim of the present study was to analyze the effect of the addition of bee products [propolis (PR) or royal jelly (RJ) or propolis and royal jelly (PR+RJ), 2–10%] to thyme (TH) and chestnut honeys (CH) on the differential anticancer properties, mainly the cytotoxic and pro-apoptotic effects, in normal and cancer hepatic cells. The cytotoxic effects of samples were analyzed using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay (0–250 mg/mL) and the effects on apoptosis were analyzed using cell cycle analysis, TdT-dUTP terminal nick-end labeling (TUNEL) assay, DR5 (Death Receptor 5) and BAX (BCL-2-Associated X) activation, and caspases 8, 9, and 3 activities. Both honey samples alone and honey mixtures had no or very little apoptotic effect on normal cells. Antioxidant honey mixtures enhanced the apoptotic capacity of the corresponding honey alone via both extrinsic and intrinsic pathways. Of all the samples, chestnut honey enriched with 10% royal jelly and 10% propolis (sample 14, CH+10RJ+10PR) showed the highest apoptotic effect on tumor liver cells. The enrichment of monofloral honey with bee products could be used together with conventional anticancer treatments as a dietary supplement without side effects. On the other hand, it could be included in the diet as a natural sweetener with high added value.

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Section: Resultsmentioning

confidence: 99%

Differential Apoptotic Effects of Bee Product Mixtures on Normal and Cancer Hepatic Cells

et al. 2023

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“…The binding rate of plasma protein of quercetin and its derivatives ranged from 85.36 to 99.82. [95] The ADME properties predicted by the ACD/I-Lab platform indicated that quercetin and 3'-methyl ether quercetin presented a maximum passive absorption of 100 %, whereas all other quercetin derivatives had an absorption of less than 15 %. [96] The intestine and liver are the main sites of quercetin metabolism.…”

Section: Discussionmentioning

confidence: 98%

“…[100] As a main metabolite of quercetin, quercetin-3-O-β-D-glucuronide can be transported to target tissues via plasma to exert the corresponding biological activity. [95] The half-life of quercetin metabolites is range from 11 to 28 hours. Absorption of quercetin is highly individualized, which may be caused by variations in metabolic enzymes and transporters in the intestine and liver.…”

Section: Discussionmentioning

confidence: 99%

“…As a flavonoid compound widely found in the daily diet, quercetin is often ingested as a glycoside and is released during chewing, digestion and absorption. The binding rate of plasma protein of quercetin and its derivatives ranged from 85.36 to 99.82 [95] . The ADME properties predicted by the ACD/I‐Lab platform indicated that quercetin and 3′‐methyl ether quercetin presented a maximum passive absorption of 100 %, whereas all other quercetin derivatives had an absorption of less than 15 % [96] .…”

Section: Discussionmentioning

confidence: 99%

“…Quercetin and its metabolites accumulated most in the lungs, liver and kidneys and could pass the blood‐brain barrier [100] . As a main metabolite of quercetin, quercetin‐3‐O‐β‐D‐glucuronide can be transported to target tissues via plasma to exert the corresponding biological activity [95] . The half‐life of quercetin metabolites is range from 11 to 28 hours.…”

Section: Discussionmentioning

confidence: 99%

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Research Progress on Quercetin's Biological Activity and Structural Modification Based on Its Antitumor Effects

Guo,

Zeng,

Sun

et al. 2023

ChemistrySelect

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Quercetin is a naturally existing flavonoid with numerous physiological effects, including antitumor activity. It functions as an antitumor agent by inducing apoptosis and inhibiting tumor cell development, preventing tumor cell invasion and metastasis, and reversing tumor multidrug resistance. Quercetin has limited therapeutic usefulness due to its low water solubility, poor oral absorption, and low bioavailability. New quercetin derivatives are being developed and manufactured via a variety of methods to address inadequacies and for utilization in disease prevention and therapy. The synthesis and anticancer effects of quercetin derivatives, as well as the structure‐activity relationship of quercetin derivatives, were explored, and the unique dosage forms of these derivatives were summarized to serve as a reference for future quercetin research and development.

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Breaking Down the Arsenal: Recent Progress in the Nanotherapeutic Strategies for Hepatocellular Carcinoma Treatment

Roy,

Harish,

Mohd

et al. 2024

Advanced Therapeutics

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Hepatocellular carcinoma (HCC) is a progressed form of advanced liver cancer and is one of the major causes of global cancer burden. The primary causes for high HCC mortality is the delayed diagnosis of the diseaseas early stage HCC is typically asymptomatic and patients frequently overlook the warning signs. Currently, the most efficacious single‐drug therapy approved by the food and drug administration (FDA) for HCC is Sorafenib and Nivolumab as a second‐line therapy for late stage HCC. Nowadays nanotechnology is used to deliver either a diagnostic tool for biomolecular imaging ortherapeutic agent. Gene therapy based on clustered regularly interspaced short palindromic repeats (CRISPR)‐CRISPR associated protein 9 (CRISPR‐Cas9) are currently studied to find a potential curative option for HCC. Natural products from plants are being extensively extracted and isolated as they may offer a promising alternative in order to control and treat HCC. They exhibit anti‐HCC effects by stimulating the immune system and by hindering various growth pathways involved in cancer development and progression. In this review article, an overview is provided on the current global incidence, ongoing systemic treatment strategies, and recent advances in nanomedicine for the management of HCC and also ongoing efforts to overcome these challenges.

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Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements

Cited by 36 publications

References 99 publications

Differential Apoptotic Effects of Bee Product Mixtures on Normal and Cancer Hepatic Cells

Differential Apoptotic Effects of Bee Product Mixtures on Normal and Cancer Hepatic Cells

Research Progress on Quercetin's Biological Activity and Structural Modification Based on Its Antitumor Effects

Breaking Down the Arsenal: Recent Progress in the Nanotherapeutic Strategies for Hepatocellular Carcinoma Treatment

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