2011
DOI: 10.2147/ijn.s18023
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Abstract: The purpose of this study was to assess the induced apoptosis of self-assembled iron oxide magnetic nanoparticles (MNPs) co-loaded with daunorubicin (DNR) and 5-bromotetrandrin (Br Tet) (DNR/Br Tet-MNPs), acting as a drug depot system for the sustained release of the loaded DNR and BrTet, in the drug resistant human leukemia K562/A02 cells and further to explore potential mechanisms. After being incubated for 48 hours, K562/A02 cells were treated with DNR/Br Tet-MNPs or DNR and Br Tet in solution (DNR/Br Tet-S… Show more

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Cited by 13 publications
(13 citation statements)
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References 23 publications
(9 reference statements)
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“… 30 – 32 Our previous studies have demonstrated the antitumor mechanisms of drugs combined with MNPs exerted cytotoxic effects by inducing apoptosis. 21 , 22 In this work, we synthesized a novel pH-dependent nanoparticle delivery system in which iron oxide cores are modified by DMSA to improve the nanoparticles aqueous dispersion. The hydrophilic surface of DMSA-MNPs also produces enough free carboxyl groups for further conjugation.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“… 30 – 32 Our previous studies have demonstrated the antitumor mechanisms of drugs combined with MNPs exerted cytotoxic effects by inducing apoptosis. 21 , 22 In this work, we synthesized a novel pH-dependent nanoparticle delivery system in which iron oxide cores are modified by DMSA to improve the nanoparticles aqueous dispersion. The hydrophilic surface of DMSA-MNPs also produces enough free carboxyl groups for further conjugation.…”
Section: Discussionmentioning
confidence: 99%
“… 18 20 One of the popular MNP drug delivery systems, Fe 3 O 4 nanoparticles, exhibit a high drug-loading ratio and fewer dose-related side effects, and remain in the circulatory system for longer without being taken up by the reticuloendothelial system, making them excellent candidates for targeted drug delivery, as demonstrated by our previous studies showing that Fe 3 O 4 nanoparticles loaded with chemotherapeutic drugs have enhanced targeted efficiency against cancer cells. 21 , 22 …”
Section: Introductionmentioning
confidence: 99%
“…The past two decades have served for the consolidation of nanomaterials as major workhorses for the development of much more potent vehicles for the transport and delivery of different types of pharmacological cargoes ranging from small synthetic molecules to nucleotide sequences [ 4 , 7 ]. In this regard, some of the delivered small molecules included oxorubicin, 5-fluorouracil, and daunorubicin for the treatment of cancer [ 8 , 9 , 10 ]. The last 5 years have also seen an exponential increase in the use of gene therapies based on gene edition such as CRISPR/Cas9, zinc finger nucleases (ZFNs), and transcription activator-like effector nucleases (TALENs).…”
Section: Introductionmentioning
confidence: 99%
“…The emergence of drug resistance in cells during leukemia treatment increases the difficulty of treatment, and has become a difficult problem in leukemia management [1,12,15]. Therefore, reversing or avoiding tumor MDR has become a focus of research [15].…”
Section: Discussionmentioning
confidence: 99%
“…Researchers are attempting to find efficient drug resistance reversal agents in traditional Chinese medicines. This study found that bufalin, extracted from a Chinese herbal medicine, inhibits tumor cell proliferation and drug resistance [12,13]. We assessed the apoptosis-inducing effect of bufalin on K562/A02 cells and analyzed the possible mechanisms involved.…”
Section: Introductionmentioning
confidence: 99%