Apoptotic induction mediated p53 mechanism and Caspase-3 activity by novel promising cyanoacrylamide derivatives in breast carcinoma

Mohamed, Magda F.; Samir, Noha; Ali, Ahmed M.; Ahmed, Naglaa A.; Ali, Yassmen; Aref, Sarah; Hossam, Omnia; Mohamed, Mervat S.; Abdelmoniem, Amr M.; Abdelhamid, Ismail A.

doi:10.1016/j.bioorg.2017.05.012

Cited by 19 publications

(13 citation statements)

References 25 publications

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“…The p53 signaling pathway plays an important role in regulating the cell cycle and cell differentiation, promoting apoptosis, and activating cell death ( 24 – 26 ). It has been previously reported that LECs exposed to H 2 O 2 -induced oxidative stress have increased expression of p53 protein ( 27 , 28 ).…”

Section: Discussionmentioning

confidence: 99%

miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts

Lü

Christensen

et al. 2018

Mol Med Report

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MicroRNA-24 (miR-24) serves an important role in cell proliferation, migration and inflammation in various types of disease. In the present study, the biological function and molecular mechanism of miR-24 was investigated in association with the progression of age-associated cataracts. To the best of our knowledge the present study is the first to report that the expression of miR-24 was significantly increased in human anterior lens capsules affected by age-associated cataracts as well as lens epithelial cells (LECs) exposed to oxidative stress. Overexpression of miR-24 induced p53 expression and p53 was verified as a direct target of miR-24. Overexpression of miR-24 enhanced LEC death by directly targeting p53. The present study revealed that oxidative stress induced the upregulation of miR-24 and enhanced LEC death by directly targeting p53. These results suggest that the miR-24-p53 signaling pathway is involved in a novel mechanism of age-associated cataractogenesis and miR-24 may be a useful therapeutic target for age-associated cataracts.

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Section: Discussionmentioning

confidence: 99%

miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts

Lü

Christensen

et al. 2018

Mol Med Report

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“…The chemistry of these molecules is of increasing interest, as they seem to be promising pharmacological compounds with anticancer, [ 2‐4 ] anti‐inflammatory, [ 5,6 ] antibacterial ( I ), [ 7‐9 ] antiproliferative, [ 10 ] antitubercular, [ 11 ] and antiviral properties. [ 12,13 ] Moreover, the acrylamide derivatives have attracted special attention due to their diverse biological and pharmacological applications such as anticancer ( II ), [ 14‐16 ] anti‐inflammatory ( III ), [ 17,18 ] antidiabetic, [ 19 ] antifungal, [ 20,21 ] and antimicrobial ( IV ) applications. [ 9,22,23 ]…”

Section: Introductionmentioning

confidence: 99%

Novel 2‐cyanoacrylamido‐4,5,6,7‐tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents

Sroor

Aboelenin

Mahrous

et al. 2020

Archiv der Pharmazie

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Ethyl 2-acrylamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate as well as its corresponding bis-derivatives, 5-10, with aliphatic linkers were synthesized, fully characterized, and tested as novel anticancer agents. The targeted compounds, 5-10, were obtained by the Knoevenagel condensation reactions of bis-o-or-p-aldehyde with a molar ratio of ethyl 2-(2-cyanoacetamido)-4,5,6,7tetrahydrobenzo[b]thiophene-3-carboxylate of 2 in the presence of piperidine in excellent yields (93-98%). The in vitro anticancer activities of the prepared compounds were evaluated against HepG2, MCF-7, HCT-116, and BJ1 cells. Compounds 7 and 9 emerged as the most promising compounds, with IC 50 values of 13.5 and 32.2 µg/ml, respectively, against HepG2 cells, compared with the reference drug doxorubicin (IC 50 : 21.6 µg/ml). Real-time reverse-transcription polymerase chain reaction was used to measure the changes in expression levels of the COL10A1 and COL11A1, ESR1, and ERBB2, or AXIN1 and CDKN2A genes within the treated cells, as genetic markers for colon, breast, or liver cancers, respectively. Treatment of the colon cancer cells with compounds 5, 9, and 10, or breast and liver cancers cells with compounds 7, 8, 9, and 10 downregulated the expression of the investigated tumor markers. The DNA damage values (depending on comet and DNA fragmentation assays) increased significantly upon treatment of colon cancer cells with compounds 5, 9, and 10, and breast and liver cells with compounds 8, 9, and 10. The structure-activity relationship suggested that the increase of the chain of the alkyl linker increases the anticancer activity and the compounds with bis-cyanoacrylamide moieties are more active than those with one cyanoacrylamide moiety.

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“…Tricyclic compounds 6 and 13 were also prepared through the reaction of malononitrile with the preheated mixture of compound 3 and aldehyde 14 . In support of this point of view, we managed to isolate the products of Knoevenagel reaction 15a , c , e as we previously reported (Scheme ).…”

Section: Resultsmentioning

confidence: 99%

2‐Cyano‐N‐(thiophen‐2‐yl)acetamide in Heterocyclic Synthesis: Synthesis and Antibacterial Screening of Novel Pyrido[1,2‐a]thieno[3,2‐e]pyrimidine‐2‐carboxylate Moieties

Abdelmoniem

Ghozlan

Abdelwahab

et al. 2019

Journal of Heterocyclic Chem

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Apoptotic induction mediated p53 mechanism and Caspase-3 activity by novel promising cyanoacrylamide derivatives in breast carcinoma

Cited by 19 publications

References 25 publications

miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts

miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts

Novel 2‐cyanoacrylamido‐4,5,6,7‐tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents

2‐Cyano‐N‐(thiophen‐2‐yl)acetamide in Heterocyclic Synthesis: Synthesis and Antibacterial Screening of Novel Pyrido[1,2‐a]thieno[3,2‐e]pyrimidine‐2‐carboxylate Moieties

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